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miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small Cell Lung Cancer by Targeting a HMGB1-Mediated NF-kB Signaling Pathway

Dandan Wu*1, Jun Liu†1, Jianliang Chen*, Haiyan He*, Hang Ma*, Xuedong Lv*

* Department of Respiratory Medicine, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China
† Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China

Oncology Research 2019, 27(2), 227-235. https://doi.org/10.3727/096504018X15213089759999

Abstract

MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains unclear. In our study, miR-449a was found to be downregulated in both NSCLC tissues and cell lines, and low miR-449a expression was obviously associated with tumor differentiation, TMN stage, and poor overall survival (OS). Moreover, we demonstrated that miR-449a could inhibit tumor proliferation, migration, and invasion in NSCLC. We also confirmed that HMGB1 was a direct target gene of miR-449a in NSCLC with dual-luciferase reporter assay, and upregulation of HMGB1 could reverse the miR-449a-induced suppression of growth, migration, and invasion in NSCLC cells. Last, we found that miR-449a suppressed tumor initiation and development through the NF- B signaling pathway. These results indicate that miR-449a functions as a tumor suppressor in NSCLC by targeting the HMGB1-mediated NF- B signaling pathway in NSCLC.

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APA Style
Wu, D., Liu, .J., Chen, .J., He, H., Ma, H. et al. (2019). Mir-449a suppresses tumor growth, migration, and invasion in non-small cell lung cancer by targeting a hmgb1-mediated nf-kb signaling pathway. Oncology Research, 27(2), 227-235. https://doi.org/10.3727/096504018X15213089759999
Vancouver Style
Wu D, Liu J, Chen J, He H, Ma H, Lv X. Mir-449a suppresses tumor growth, migration, and invasion in non-small cell lung cancer by targeting a hmgb1-mediated nf-kb signaling pathway. Oncol Res. 2019;27(2):227-235 https://doi.org/10.3727/096504018X15213089759999
IEEE Style
D. Wu, .J. Liu, .J. Chen, H. He, H. Ma, and X. Lv "miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small Cell Lung Cancer by Targeting a HMGB1-Mediated NF-kB Signaling Pathway," Oncol. Res., vol. 27, no. 2, pp. 227-235. 2019. https://doi.org/10.3727/096504018X15213089759999



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