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  • Open Access

    REVIEW

    MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools

    ELHAM SHAKIBA1, SETI BOROOMAND2, SIMA KHERADMAND KIA3, MEHDI HEDAYATI4,*

    Oncology Research, Vol.32, No.6, pp. 1011-1019, 2024, DOI:10.32604/or.2024.049235

    Abstract This review aimed to describe the inculpation of microRNAs (miRNAs) in thyroid cancer (TC) and its subtypes, mainly medullary thyroid carcinoma (MTC), and to outline web-based tools and databases for bioinformatics analysis of miRNAs in TC. Additionally, the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be discussed. This review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes, mainly MTC. Additionally, web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and described. MiRNAs can… More > Graphic Abstract

    MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools

  • Open Access

    ARTICLE

    CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

    JUNZHE YI1,#, BINBIN LI2,#, XIAOMIN YIN3, LINGRUI LIU1, CAILU SONG1, YING ZHAO4, MANBO CAI3, HAILIN TANG1, DONG CHEN4,*, NING LYU1,*

    Oncology Research, Vol.32, No.6, pp. 1129-1139, 2024, DOI:10.32604/or.2024.047524

    Abstract Circular RNAs (circRNAs) have been recognized as pivotal regulators in tumorigenesis, yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma (HCC) remain elusive. We sought to unveil the expression profile and biological role of circMYBL2 in HCC. Initial microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells, and qRT‒PCR analysis was then performed in HCC cell lines and tissues, revealing significant upregulation of circMYBL2. Subsequent experiments were conducted to evaluate the biological function of circMYBL2 in HCC progression. Furthermore, bioinformatics analysis, qRT‒PCR… More >

  • Open Access

    ARTICLE

    PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma

    KUN FENG1,#, HAO PENG2,#, QINGPENG LV1, YEWEI ZHANG1,*

    Oncology Research, Vol.32, No.6, pp. 1063-1078, 2024, DOI:10.32604/or.2024.047078

    Abstract Hepatocellular carcinoma (HCC) is a malignancy known for its unfavorable prognosis. The dysregulation of the tumor microenvironment (TME) can affect the sensitivity to immunotherapy or chemotherapy, leading to treatment failure. The elucidation of PHLDA2’s involvement in HCC is imperative, and the clinical value of PHLDA2 is also underestimated. Here, bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of HCC. Then, the expression and function of PHLDA2 were examined via the qRT-PCR, Western Blot, and MTT assays. Our findings indicate a substantial upregulation of… More >

  • Open Access

    ARTICLE

    GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

    CHAO TANG1,#, CHUNYU ZHONG2,#, JUNHAO ZHU1, FENG YUAN1, JIN YANG1, YONG XU3,*, CHIYUAN MA1,3,4,5,*

    Oncology Research, Vol.32, No.6, pp. 1079-1091, 2024, DOI:10.32604/or.2024.046007

    Abstract Approximately 30%–40% of growth hormone–secreting pituitary adenomas (GHPAs) harbor somatic activating mutations in GNAS (α subunit of stimulatory G protein). Mutations in GNAS are associated with clinical features of smaller and less invasive tumors. However, the role of GNAS mutations in the invasiveness of GHPAs is unclear. GNAS mutations were detected in GHPAs using a standard polymerase chain reaction (PCR) sequencing procedure. The expression of mutation-associated maternally expressed gene 3 (MEG3) was evaluated with RT-qPCR. MEG3 was manipulated in GH3 cells using a lentiviral expression system. Cell invasion ability was measured using a Transwell assay, and epithelial–mesenchymal transition… More >

  • Open Access

    ARTICLE

    Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

    YUE ZHANG1,#, WENYU YANG1,#, XIAOWANG HAN1,#, YUE QIAO1, HAITAO WANG2, TING CHEN1, TIANYING LI1, WEN-BIN OU1,*

    Oncology Research, Vol.32, No.6, pp. 1119-1128, 2024, DOI:10.32604/or.2024.045025

    Abstract It has been shown that the high expression of human epididymis protein 4 (HE4) in most lung cancers is related to the poor prognosis of patients, but the mechanism of pathological transformation of HE4 in lung cancer is still unclear. The current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma (LUAD). Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies, and through analysis of The Cancer Genome Atlas (TCGA) dataset. Frequent HE4 overexpression was demonstrated in LUAD, but not in lung squamous… More >

  • Open Access

    ARTICLE

    Improving Channel Estimation in a NOMA Modulation Environment Based on Ensemble Learning

    Lassaad K. Smirani1, Leila Jamel2,*, Latifah Almuqren2

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1315-1337, 2024, DOI:10.32604/cmes.2024.047551

    Abstract This study presents a layered generalization ensemble model for next generation radio mobiles, focusing on supervised channel estimation approaches. Channel estimation typically involves the insertion of pilot symbols with a well-balanced rhythm and suitable layout. The model, called Stacked Generalization for Channel Estimation (SGCE), aims to enhance channel estimation performance by eliminating pilot insertion and improving throughput. The SGCE model incorporates six machine learning methods: random forest (RF), gradient boosting machine (GB), light gradient boosting machine (LGBM), support vector regression (SVR), extremely randomized tree (ERT), and extreme gradient boosting (XGB). By generating meta-data from five… More >

  • Open Access

    ARTICLE

    High Prevalence of Anatomical Variations and Anomalies of the Coronary Arteries Detected by CT Angiography in Symptomatic Patients

    Ghazi A. Alshumrani*

    Congenital Heart Disease, Vol.19, No.2, pp. 197-206, 2024, DOI:10.32604/chd.2024.049401

    Abstract Objective: Coronary artery anatomical variations and anomalies are an important topic due to their potential clinical manifestations. This study aims to investigate the prevalence of coronary artery anatomical variations and anomalies in symptomatic patients with coronary computed tomography angiography (CCTA). Methods: This is a retrospective study that included all symptomatic patients who had CCTA in a tertiary care hospital in Saudi Arabia during a period of seven years. Results: The total number of included patients was 507 (60% males) with a mean age of 57.4 years. Approximately 41% had luminal stenoses, averaging 49.7%. The total number… More >

  • Open Access

    ARTICLE

    FusionNN: A Semantic Feature Fusion Model Based on Multimodal for Web Anomaly Detection

    Li Wang1,2,3,*, Mingshan Xia1,2,*, Hao Hu1, Jianfang Li1,2, Fengyao Hou1,2, Gang Chen1,2,3

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2991-3006, 2024, DOI:10.32604/cmc.2024.048637

    Abstract With the rapid development of the mobile communication and the Internet, the previous web anomaly detection and identification models were built relying on security experts’ empirical knowledge and attack features. Although this approach can achieve higher detection performance, it requires huge human labor and resources to maintain the feature library. In contrast, semantic feature engineering can dynamically discover new semantic features and optimize feature selection by automatically analyzing the semantic information contained in the data itself, thus reducing dependence on prior knowledge. However, current semantic features still have the problem of semantic expression singularity, as… More >

  • Open Access

    ARTICLE

    3-Methyladenine potentiates paclitaxel-induced apoptosis and phosphorylation of cyclin-dependent kinase 1 at thr161 in nasopharyngeal carcinoma cell

    XIAOQI WU1,2,#, YECHUAN HE1,2,#, YEQIN YUAN4, XIAN TAN1,2, LIN ZHU1,2, DANLING WANG1,2,4, BINYUAN JIANG3,4,*

    BIOCELL, Vol.48, No.5, pp. 861-872, 2024, DOI:10.32604/biocell.2024.048758

    Abstract Background: Nasopharyngeal carcinoma (NPC) exhibits a significant prevalence in the southern regions of China, and paclitaxel (PTX) is frequently employed as a medication for managing advanced NPC. However, drug resistance is typically accompanied by a poor prognosis. Exploring the synergistic potential of combining multiple chemotherapeutic agents may represent a promising avenue for optimizing treatment efficacy. Methods: This study investigated whether 3-Methyladenine (3-MA) could potentiated the effect of PTX and its potential molecular mechanism. Samples were divided into the following categories: Negative control (NC) with the solvent dimethyl sulfoxide (DMSO, 0.5% v/v), PTX (400 nM), 3-MA… More >

  • Open Access

    ARTICLE

    CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

    KAIWEN TIAN#, HANZHONG CHEN#, QIANQIAN WANG, FENGLIAN JIANG, CHUNXIANG FENG, TENG LI, XIAOYONG PU, YANLIN TANG*, JIUMIN LIU*

    BIOCELL, Vol.48, No.5, pp. 817-834, 2024, DOI:10.32604/biocell.2024.048737

    Abstract Background: The incidence of clear cell renal cell carcinoma (ccRCC) is globally high; however, despite the introduction of innovative drug therapies, there remains a lack of effective biomarkers for evaluating treatment response. Recently, Caspase recruiting domain-containing protein 11 (CARD11) has garnered attention due to its significant association with tumor development and the immune system. Methods: The expression of CARD11 mRNA and protein in ccRCC were analyzed by public database and immunohistochemistry. The focus of this study is on the epigenomic modifications of CARD11, its expression of ccRCC immunophenotype, and its correlation with response to immunotherapy… More > Graphic Abstract

    CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

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