YANG-YANG SHUAI^1,2, PEI-PEI WANG¹, HAI-JUN ZHANG², HUI AO^1,*, WEI PENG¹, HONG ZHANG^1,2,*

BIOCELL, Vol.49, No.12, pp. 2299-2333, 2025, DOI:10.32604/biocell.2025.071569 - 24 December 2025

Abstract Breast cancer ranks first among cancer-related fatalities and is the most frequent cancer in women globally. ROS plays an important role in controlling the occurrence and progression of breast cancer. Increasing reports suggest that natural products and their derivatives are beneficial for the management of breast cancer via the regulation of reactive oxygen species (ROS). A summary of the known patterns of natural products that modulate ROS against breast cancer will contribute to the discovery of more natural medicines for clinical applications and the development of new drugs. In this review, the pharmacological effects of More >

Yuhan Xie¹, Shaden A. M. Khalifa², Hesham R. El-Seedi³, Paolo Coghi^1,4,*

Oncology Research, Vol.33, No.10, pp. 2673-2697, 2025, DOI:10.32604/or.2025.067666 - 26 September 2025

Abstract Podophyllotoxin is a well-studied natural product. Because of its unique structure and ability to inhibit cancer cells, it has been changed in different ways to find out its pharmacological properties. This paper discusses the common chemical modifications of podophyllotoxin molecules, including the C-4 and E-4 site replacements. Furthermore, its common inhibitory effects on cancer cells and antiparasitic activities, among others, are outlined by the connection between conformational changes and pharmacological activities. Importantly, Podophyllotoxin can effectively overcome the phenomenon of multidrug resistance through a dual-targeting mechanism, including inhibition of microtubule protein synthesis and topoisomerase II activity, More > Graphic Abstract

MD. MAHMUDUL HASAN^1,2, SHAH MD. WASIN^2,3, MISHU RAHMAN^2,4, EVA AZME^1,2, MD. SAQLINE MOSTAQ⁵, MD. MAHEDI HASAN NAHID⁶, NOR MOHAMMAD⁷, FARJANA AFRIN TANJUM⁸, MD. ANAMUL HAQUE⁵, MD ASHIQ MAHMUD^5,*, MOHAMMAD NURUL AMIN^5,*

Oncology Research, Vol.33, No.7, pp. 1611-1632, 2025, DOI:10.32604/or.2025.062778 - 26 June 2025

Abstract Background: Breast cancer still stands to be the foremost contributor to cancer-related incidence and mortality in women globally accounting for about 14% of all female cancer-related deaths worldwide. This research seeks to illustrate the mechanisms and clinical findings of natural products against breast cancer treatment. Methodology: Required data for this review article was retrieved employing several readily obtainable search databases, including Web of Science^® (Thomson Reuters, USA), PubMed^® (U.S. National Library of Medicine, USA), and SciVerse Scopus^® (Elsevier Properties S.A., USA), taking into consideration certain search terms like “breast cancer,” “natural products against breast cancer,” and “Clinically… More > Graphic Abstract

LINGLI ZHANG^1,2,#, YAN LI^1,#, JINGXIN MAO^1,*

BIOCELL, Vol.48, No.6, pp. 905-922, 2024, DOI:10.32604/biocell.2024.050396 - 10 June 2024

Abstract Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research. Particularly, we provide an outline More >

ANWAR ALI^1,#, SREEKANTH REDDY OBIREDDY^2,#, WING-FU LAI^3,*

BIOCELL, Vol.48, No.2, pp. 163-171, 2024, DOI:10.32604/biocell.2023.043839 - 23 February 2024

Abstract Farnesol is a C15 isoprenyl alcohol generated from the hydrolysis of farnesyl diphosphate under the action of farnesol synthase in plants. Although this sesquiterpenoid alcohol has been exploited in a wide variety of industrial applications, serious discussions on the possible use of this agent in disease treatment have been scant until now. In this article, we review the current understanding of the physiological properties of farnesol and the potential use of the agent as a candidate for treatment development. In fact, since the turn of the last century, farnesol has been found not only to More >

ZEINAB KLAAB¹, AZIZA HASSAN², JAWAHER ALBAQAMI¹, FAIZAH A. ALMALKI^1,*

BIOCELL, Vol.47, No.4, pp. 891-904, 2023, DOI:10.32604/biocell.2023.026556 - 08 March 2023

Abstract Cancer remains to be one of the most severe sicknesses globally. Cases have kept rising over the years. Breast cancer (BC), which is among the leading types of cancers and predominantly affects women, is the second leading cause of cancer mortality. Researchers have developed interventions over the years; however, the BC survival rate has not improved since the 1980s. This has created the need for novel drug interventions that would manage and treat BC more effectively. This study focused on using a combination of natural product extracts such as phytoestrogen (Ziziphus jujube) and Tannin nanoparticles (NP99)… More >

Nada M. Mostafa^1,5,#, Muhammad I. Ismail^2,#, Amr M. El-Araby³, Dina M. Bahgat¹, Ahmed M. Elissawy^1,5, Ahmed M. Mostafa⁴, Omayma A. Eldahshan^1,5,*, Abdel Nasser B. Singab^1,5,*

Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 1089-1104, 2022, DOI:10.32604/phyton.2022.018239 - 24 January 2022

Abstract Coronaviruses caused an outbreak pandemic disease characterized by a severe acute respiratory distress syndrome leading to the infection of more than 200 million patients and the death of more than 4 million individuals. The primary treatment is either supportive or symptomatic. Natural products have an important role in the development of various drugs. Thus, screening of natural compounds with reported antiviral activities can lead to the discovery of potential inhibitory entities against coronaviruses. In the current study, an in-silico molecular docking experiment was conducted on the effects of some of these natural antiviral phytoconstituents, (e.g.,… More >

REKHA GAHTORI^1,#, MOSLEH MOHAMMAD ABOMUGHAID^2,#, NIDHI NEGI³, SARAVANAN KRISHNAN⁴, SUGAPRIYA DHANASEKARAN⁵, SOUMYA PANDIT⁶, KANU PRIYA⁶, DILLIP KUMAR BISHI^7,*, RAM PRASAD⁸, PIYUSH KUMAR GUPTA^6,*

BIOCELL, Vol.45, No.6, pp. 1465-1477, 2021, DOI:10.32604/biocell.2021.016484 - 01 September 2021

Abstract Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to More >