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Delineating the role of phytocompounds against anti-bacterial drug resistance–An update

REKHA GAHTORI1,#, MOSLEH MOHAMMAD ABOMUGHAID2,#, NIDHI NEGI3, SARAVANAN KRISHNAN4, SUGAPRIYA DHANASEKARAN5, SOUMYA PANDIT6, KANU PRIYA6, DILLIP KUMAR BISHI7,*, RAM PRASAD8, PIYUSH KUMAR GUPTA6,*

1 Department of Biotechnology, Sir J. C. Bose Technical Campus, Kumaun University, Nainital, India
2 Department of Medical Laboratory Sciences, University of Bisha, Bisha, Saudi Arabia
3 Department of Chemistry, Kumaun University, Nainital, India
4 Dhanvantari Nano Ayushadi Pvt., Ltd., Chennai, India
5 Department of Medical Laboratory Sciences (Pathology), College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Riyadh, Saudi Arabia
6 Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, India
7 Department of Biotechnology, Rama Devi Women’s University, Bhubaneswar, India
8 Department of Botany, Mahatma Gandhi Central University, Motihari, India

* Corresponding Authors: Piyush Kumar Gupta, email; Dillip Kumar Bishi, email
# These authors have contributed equally to this work

BIOCELL 2021, 45(6), 1465-1477. https://doi.org/10.32604/biocell.2021.016484

Abstract

Antibacterial resistance developed by bacteria due to the unlimited use of antibiotics has posed a challenge for human civilization. This kind of problem is not limited to India only, but it is a global concern. Nowadays, many treatments and medicines for bacterial diseases have been developed. However, they possess some drawbacks. Therefore, the alternative medicine has been used to target the drug resistant mechanisms and such medicines have less side effects which is becoming necessary. Natural products have traditionally or historically been of importance for the development of antibacterial agents and are also known to overcome bacterial drug resistance by directly targeting the drug resistance mechanisms in bacteria. In recent years, researchers have also focused on new drug discovery from plant-based research. They have looked on various phytocompounds as antibacterial agents. In the current review, we report various classes of secondary metabolites such as phenolic compounds, flavonoids, alkaloids, saponins, terpenes, quinones, and some essential oils that have been used as an antibacterial agent. In addition, we also discuss several mechanisms behind bacterial multi-drug resistance that are used during bacterial pathogenesis.

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GAHTORI, R., ABOMUGHAID, M. M., NEGI, N., KRISHNAN, S., DHANASEKARAN, S. et al. (2021). Delineating the role of phytocompounds against anti-bacterial drug resistance–An update. BIOCELL, 45(6), 1465–1477.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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