XINWEI WU1, GUOYONG JIA2,*, HONGNA YANG3, CONGCONG SUN2, YING LIU2, ZENGYAN DIAO2
BIOCELL, Vol.46, No.2, pp. 471-478, 2022, DOI:10.32604/biocell.2021.015701
Abstract A progressive neurodegenerative disease, Alzheimer’s disease (AD). Studies suggest that highly expressed
protein isoaspartate methyltransferase 1 (PCMT1) in brain tissue. In the current study, we explored the effects of
neural stem cell-conditioned medium (NSC-CDM) on the PCMT1/MST1 pathway to alleviate Aβ25-35-induced
damage in SH-SY5Y cells. Our data suggested that Aβ25-35 markedly inhibited cell viability. NSC-CDM or Neural
stem cell-complete medium (NSC-CPM) had a suppression effect on toxicity when treatment with Aβ25-35, with a
greater effect observed with NSC-CDM. Aβ25-35 + NSC-CDM group exhibited an increase in PCMT1 expression.
sh-PCMT1 markedly decreased cell proliferation and suppressed the protective role of NSC-CDM… More >
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