Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

ALFREDO FRANCO-OBREGÓN^*

BIOCELL, Vol.47, No.2, pp. 239-244, 2023, DOI:10.32604/biocell.2023.025357 - 18 November 2022

Abstract An organism’s survival depends on its ability to adapt to stress. Mitochondria are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level, and are thus central to the process whereby organisms adapt to their respective environments. Mitochondria produce molecular energy via oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their environment. Reactive oxygen species (ROS) are by-products of oxidative phosphorylation that can be either beneficial or damaging, depending on the context; ROS are hence both the conveyors of environmental stress as well as More >

NADIA Z. SHAABAN¹, NASHWA K. IBRAHIM², HELEN N. SAADA², FATMA H. EL-RASHIDY¹, HEBATALLAH M. SHAABAN³, NERMEEN M. ELBAKARY^2,*, AHMAD S. KODOUS^1,2,*

Oncology Research, Vol.30, No.6, pp. 269-276, 2022, DOI:10.32604/or.2022.027277 - 09 February 2023

Abstract Background: MicroRNAs (miRs) are small (19–25 nucleotides), non-protein coding RNAs that regulate gene expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of several miRs is dysregulated in human cancer. Methods: The study includes 179 female patients and 58 healthy women Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer More >

Alberto Cipriani^1,#, Pietro Bernardo Dall’Aglio^1,#, Laura Mazzotta¹, Domenico Sirico², George Sarris³, Mark Hazekamp⁴, Thierry Carrel⁵, Alessandro Frigiola⁶, Vladimir Sojak⁴, Mauro Lo Rito⁶, Jurgen Horer⁷, Regine Roussin⁷, Julie Cleuziou⁸, Bart Meyns⁹, Jose Fragata¹⁰, Helena Telles¹⁰, Anastasios C. Polimenakos¹¹, Katrien Francois¹², Altin Veshti¹³, Jukka Salminen¹⁴, Alvaro Gonzalez Rocafort¹⁵, Matej Nosal¹⁶, Eleftherios Protopapas³, Roberto Tumbarello¹⁷, Patrizio Sarto¹⁸, Cinzia Pegoraro¹⁸, Raffaella Motta¹⁹, Giovanni Di Salvo², Domenico Corrado¹, Vladimiro L. Vida¹, Massimo A. Padalino^1,2,*

Congenital Heart Disease, Vol.17, No.4, pp. 375-385, 2022, DOI:10.32604/chd.2022.019385 - 04 July 2022

Abstract Background: Anomalous aortic origin of a coronary artery (AAOCA) is a congenital heart disease with a 0.3%−0.5% prevalence. Diagnosis is challenging due to nonspecific clinical presentation. Risk stratification and treatment are currently based on expert consensus and single-center case series. Methods: Demographical and clinical data of AAOCA patients from 17 tertiary-care centers were analyzed. Diagnostic imaging studies (Bidimensional echocardiography, coronary computed tomography angiography [CCTA] were collected. Clinical correlations with anomalous coronary course and origin were evaluated. Results: Data from 239 patients (42% males, mean age 15 y) affected by AAOCA were collected; 154 had AAOCA involving the… More > Graphic Abstract

Mujeeb Ur Rehman^1,*, Maha Driss^2,3, Abdukodir Khakimov⁴, Sohail Khalid¹

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5681-5697, 2022, DOI:10.32604/cmc.2022.025840 - 21 April 2022

Abstract Lungs are a vital human body organ, and different Obstructive Lung Diseases (OLD) such as asthma, bronchitis, or lung cancer are caused by shortcomings within the lungs. Therefore, early diagnosis of OLD is crucial for such patients suffering from OLD since, after early diagnosis, breathing exercises and medical precautions can effectively improve their health state. A secure non-invasive early diagnosis of OLD is a primordial need, and in this context, digital image processing supported by Artificial Intelligence (AI) techniques is reliable and widely used in the medical field, especially for improving early disease diagnosis. Hence,… More >

Anurag Jain¹, Kusum Yadav², Hadeel Fahad Alharbi², Shamik Tiwari^1,*

CMC-Computers, Materials & Continua, Vol.71, No.1, pp. 423-438, 2022, DOI:10.32604/cmc.2022.020238 - 03 November 2021

Abstract Corona is a viral disease that has taken the form of an epidemic and is causing havoc worldwide after its first appearance in the Wuhan state of China in December 2019. Due to the similarity in initial symptoms with viral fever, it is challenging to identify this virus initially. Non-detection of this virus at the early stage results in the death of the patient. Developing and densely populated countries face a scarcity of resources like hospitals, ventilators, oxygen, and healthcare workers. Technologies like the Internet of Things (IoT) and artificial intelligence can play a vital… More >

Abdulfattah Noorwali¹, Ameni Yengui^2,*, Kaiçar Ammous², Anis Ammous¹

Intelligent Automation & Soft Computing, Vol.32, No.1, pp. 455-466, 2022, DOI:10.32604/iasc.2022.020574 - 26 October 2021

Abstract Early fetal cardiac diseases and heart abnormalities can be detected and appropriately treated by monitoring fetal health during pregnancy. Advancements in computer sciences and the technology of sensors show that is possible to monitor fetal electrocardiogram (fECG). Both signal processing and experimental aspects are needed to be investigated to monitor fECG. In this study, we aim to design and realize a non invasive fECG monitoring system. In the first part of this work, a remote study process of the electrical activity of the heart is achieved. In fact, our proposed design considers transmitting the detected… More >

Chih-Ta Yen^1,*, Sheng-Nan Chang², Liao Jia-Xian³, Yi-Kai Huang³

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2937-2952, 2022, DOI:10.32604/cmc.2022.020493 - 27 September 2021

Abstract This study proposed a measurement platform for continuous blood pressure estimation based on dual photoplethysmography (PPG) sensors and a deep learning (DL) that can be used for continuous and rapid measurement of blood pressure and analysis of cardiovascular-related indicators. The proposed platform measured the signal changes in PPG and converted them into physiological indicators, such as pulse transit time (PTT), pulse wave velocity (PWV), perfusion index (PI) and heart rate (HR); these indicators were then fed into the DL to calculate blood pressure. The hardware of the experiment comprised 2 PPG components (i.e., Raspberry Pi 3… More >

Qingzhu Song¹, Fenglan Zhang², Tian Yuan², Yulong Wei²

European Cytokine Network, Vol.32, No.2, pp. 39-47, 2021, DOI:10.1684/ecn.2021.0468

Abstract Breast cancer is by far the most common malignancy found in women and causes a significant public health problem around the world. Early diagnosis of cancer plays an important role in successful treatment and survival of patients. This study aims to investigate the possibility of plasma Tie2 to be used as a biomarker for diagnosis of breast cancer. In total, 20 healthy volunteers and 33 breast cancer patients were considered for this study. The level of Tie2 in plasma was detected using the ELISA technique and immunohistochemistry was performed to measure the expression of Tie2… More >

Alex Uhr¹, Lydia Glick¹, Suzanne Barron¹, Jillian Zavodnick², James R. Mark¹, Patrick Shenot¹, Alana Murphy¹

Canadian Journal of Urology, Vol.28, No.3, pp. 10669-10672, 2021

Abstract Catheter associated urinary tract infections (CAUTIs) are common hospital-acquired infections and remain a significant medical and financial challenge to the healthcare system. Despite this risk, incontinent women may require prolonged catheterization to accurately monitor urine output and prevent skin breakdown. The PureWick Female External Urinary Catheter is a promising non-invasive urine collection system for use in incontinent women that may help reduce CAUTI rates, maintain skin integrity, accurately quantify urine output, and avoid extra healthcare costs. More >