Qian Xiao1, Xia Tang1, Yuanxiu Chen1, Han Bao1, Lizhi Gao1,2, Xiaobo Gong3,*, Ping Zhang1,4,*
Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 199-210, 2019, DOI:10.32604/mcb.2019.07107
Abstract Adrenocorticotrophic hormone (ACTH), a 39-amino acid peptide hormone, has been reported in the appreciation of the proliferation of vascular smooth muscle cells (VSMCs), however, the mechanism in molecular scale supporting the appreciation remains to be elucidated. In this study, we observed that the protein expression levels of ACTH at 24 h after exposure to 15% cyclic stretch were significantly higher than that after 5% cyclic stretch. When VSMCs were treated with 1000 nM ACTH directly, Oct-1 and lamin B1 expression were both up-regulated associating with each other, and the presence of Oct-1 was found shuttling between the cytosol and nucleus.… More >
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