J.A.Ferreira2,3, P. Oliveira1, P.M. Silva4, A. Carreira5,3, J.N. Murta6
CMES-Computer Modeling in Engineering & Sciences, Vol.60, No.2, pp. 151-180, 2010, DOI:10.3970/cmes.2010.060.151
Abstract This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles.
The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. More >
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