USAMA SHARIF AHMAD, KARTHIK SARAVANAN, HONG WAN^*

Oncology Research, Vol.29, No.6, pp. 377-391, 2021, DOI:10.32604/or.2022.026085

Abstract The Yes-associated protein (YAP) is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration, proliferation, and survival. The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size. Dysregulation and heterogeneity of this pathway are found in cancers, including oral squamous cell carcinoma (OSCC), leading to overexpression of YAP and its regulated proliferation machinery. The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation. This review focuses on the role of YAP… More >

Mesfer Al Duhayyim^1,*, Areej A. Malibari², Sami Dhahbi³, Mohamed K. Nour⁴, Isra Al-Turaiki⁵, Marwa Obayya⁶, Abdullah Mohamed⁷

Computer Systems Science and Engineering, Vol.45, No.1, pp. 753-767, 2023, DOI:10.32604/csse.2023.030556

Abstract Recently, computer aided diagnosis (CAD) model becomes an effective tool for decision making in healthcare sector. The advances in computer vision and artificial intelligence (AI) techniques have resulted in the effective design of CAD models, which enables to detection of the existence of diseases using various imaging modalities. Oral cancer (OC) has commonly occurred in head and neck globally. Earlier identification of OC enables to improve survival rate and reduce mortality rate. Therefore, the design of CAD model for OC detection and classification becomes essential. Therefore, this study introduces a novel Computer Aided Diagnosis for OC using Sailfish Optimization with… More >

K. Shankar¹, E. Laxmi Lydia², Sachin Kumar^1,*, Ali S. Abosinne³, Ahmed alkhayyat⁴, A. H. Abbas⁵, Sarmad Nozad Mahmood⁶

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 4541-4557, 2022, DOI:10.32604/cmc.2022.031247

Abstract Oral Squamous Cell Carcinoma (OSCC) is a type of Head and Neck Squamous Cell Carcinoma (HNSCC) and it should be diagnosed at early stages to accomplish efficient treatment, increase the survival rate, and reduce death rate. Histopathological imaging is a wide-spread standard used for OSCC detection. However, it is a cumbersome process and demands expert’s knowledge. So, there is a need exists for automated detection of OSCC using Artificial Intelligence (AI) and Computer Vision (CV) technologies. In this background, the current research article introduces Improved Slime Mould Algorithm with Artificial Intelligence Driven Oral Cancer Classification (ISMA-AIOCC) model on Histopathological images… More >

Radwa Marzouk¹, Eatedal Alabdulkreem², Sami Dhahbi³, Mohamed K. Nour⁴, Mesfer Al Duhayyim⁵, Mahmoud Othman⁶, Manar Ahmed Hamza^7,*, Abdelwahed Motwakel⁷, Ishfaq Yaseen⁷, Mohammed Rizwanullah⁷

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3905-3920, 2022, DOI:10.32604/cmc.2022.029326

Abstract Oral cancer is the most commonly occurring ‘head and neck cancers’ across the globe. Most of the oral cancer cases are diagnosed at later stages due to absence of awareness among public. Since earlier identification of disease is essential for improved outcomes, Artificial Intelligence (AI) and Machine Learning (ML) models are used in this regard. In this background, the current study introduces Artificial Intelligence with Deep Transfer Learning driven Oral Cancer detection and Classification Model (AIDTL-OCCM). The primary goal of the proposed AIDTL-OCCM model is to diagnose oral cancer using AI and image processing techniques. The proposed AIDTL-OCCM model involves… More >

FRANCESCO PADUANO^1,2,*, EMANUELA ALTOMARE^2,3, BENEDETTA MARRELLI¹, VINCENZO DATTILO⁴, HAIZAL MOHD HUSSAINI⁵, PAUL ROY COOPER⁵, MARCO TATULLO⁶

BIOCELL, Vol.46, No.8, pp. 1827-1835, 2022, DOI:10.32604/biocell.2022.020462

Abstract Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases have been systematically investigated for… More >