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  • Open Access

    ARTICLE

    Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC)

    Jeong Yong Jeon*1, Misu Lee*†1, Sang Hyun Whang*, Jung-Whan Kim, Arthur Cho*, Mijin Yun*

    Oncology Research, Vol.26, No.1, pp. 71-81, 2018, DOI:10.3727/096504017X14902648894463

    Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [18F]fluorodeoxyglucose (FDG) and [11C]acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells. In this study, we evaluated the mechanism and roles of [11C]acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of [11C]acetate uptake in HCC cell lines and human HCCs with different [11C]acetate uptake. Using two representative cell lines with widely different [11C]acetate uptake (HepG2 for high… More >

  • Open Access

    ARTICLE

    COVID-19 vaccine related hypermetabolic lymph nodes on PET/CT: Implications of inflammatory findings in cancer imaging

    FERDINANDO CALABRIA1, ANTONIO BAGNATO1, GIULIANA GUADAGNINO2, MARIA TOTEDA1, ANTONIO LANZILLOTTA1, STEFANIA CARDEI1, ROSANNA TAVOLARO1, MARIO LEPORACE1,*

    Oncology Research, Vol.31, No.2, pp. 117-124, 2023, DOI:10.32604/or.2023.027705

    Abstract We observed several patients presenting 2-[18F]FDG uptake in the reactive axillary lymph node at PET/CT imaging, ipsilateral to the site of the COVID-19 vaccine injection. Analog finding was documented at [18F]Choline PET/CT. The aim of our study was to describe this source of false positive cases. All patients examined by PET/CT were included in the study. Data concerning patient anamnesis, laterality, and time interval from recent COVID-19 vaccination were recorded. SUVmax was measured in all lymph nodes expressing tracer uptake after vaccination. Among 712 PET/CT scans with 2-[18F]FDG, 104 were submitted to vaccination; 89/104 patients (85%) presented… More >

  • Open Access

    ARTICLE

    L’exploration axillaire : un standard du bilan préthérapeutique
    Axillary Evaluation: a Standard in Pretreatment Staging

    S. Dejust

    Oncologie, Vol.21, No.1, pp. 5-10, 2019, DOI:10.3166/onco-2019-0031

    Abstract Axillary evaluation is a major step in the initial staging of breast cancer. Ultrasound guided biopsy is currently recommended in first-line. MRI and 18FDG PET/CT are useful in axillary lymph node evaluation. Imaging sensitivities and specificities are globally identical and their combination allows obtaining the best performances. Currently, sentinel node technique is essential in case of T1-T2 N0 mammary tumors and in case of suspected lymph node adenopathy with negative cytopuncture or microbiopsy.


    Résumé
    L’exploration préthérapeutique axillaire est une étape majeure du bilan initial du cancer du sein. L’échographie associée à un prélèvement est actuellement recommandée en première More >

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