Yuhan Xie¹, Shaden A. M. Khalifa², Hesham R. El-Seedi³, Paolo Coghi^1,4,*

Oncology Research, Vol.33, No.10, pp. 2673-2697, 2025, DOI:10.32604/or.2025.067666 - 26 September 2025

Abstract Podophyllotoxin is a well-studied natural product. Because of its unique structure and ability to inhibit cancer cells, it has been changed in different ways to find out its pharmacological properties. This paper discusses the common chemical modifications of podophyllotoxin molecules, including the C-4 and E-4 site replacements. Furthermore, its common inhibitory effects on cancer cells and antiparasitic activities, among others, are outlined by the connection between conformational changes and pharmacological activities. Importantly, Podophyllotoxin can effectively overcome the phenomenon of multidrug resistance through a dual-targeting mechanism, including inhibition of microtubule protein synthesis and topoisomerase II activity, More > Graphic Abstract

Wei Hu¹, Dan Xiong^2,*

BIOCELL, Vol.49, No.9, pp. 1711-1731, 2025, DOI:10.32604/biocell.2025.067670 - 25 September 2025

Abstract Objectives: Podocytes undergo epithelial-mesenchymal transition (EMT) and ferroptosis in response to hyperglycemic stimulation. This is considered an important early event in the development and progression of diabetic nephropathy (DN). Rhein is the main active anthraquinone derivative in several common traditional herbal medicines. This study aimed to investigate the protective effects of Rhein on podocyte ferroptosis and EMT. Methods: The mouse glomerular podocyte cell line MPC5 was stimulated with high glucose (HG), Rhein, and the ferroptosis inhibitor ferrostatin-1 (Fer-1). Mechanistic investigations employed plasmids to overexpress and knockdown Sirtuin-1 (SIRT1), solute carrier family 7 member 11 (SLC7A11),… More >

Absar Hussain¹, Abdul Aziz¹, Hassan Jamil Syed^2,*, Shoaib Raza¹

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3105-3124, 2025, DOI:10.32604/cmc.2025.062628 - 03 July 2025

Abstract Kubernetes has become the dominant container orchestration platform, with widespread adoption across industries. However, its default pod-to-pod communication mechanism introduces security vulnerabilities, particularly IP spoofing attacks. Attackers can exploit this weakness to impersonate legitimate pods, enabling unauthorized access, lateral movement, and large-scale Distributed Denial of Service (DDoS) attacks. Existing security mechanisms such as network policies and intrusion detection systems introduce latency and performance overhead, making them less effective in dynamic Kubernetes environments. This research presents PodCA, an eBPF-based security framework designed to detect and prevent IP spoofing in real time while minimizing performance impact. PodCA… More >

Jung-Il Chae^1,#, Ji-Hye Seo^1,#, Goo Yoon², Young-Joo Jeon^3,*, Woo-Keun Kim^4,*

BIOCELL, Vol.49, No.4, pp. 647-663, 2025, DOI:10.32604/biocell.2025.062137 - 30 April 2025

Abstract Background: Picropodophllotoxin (PPT), a principal component of Podophyllum hexandrum root, demonstrates various beneficial biological activities in multiple cancer types, including antitumor and antiproliferative properties. Despite its known effects, the specific mechanisms by which PPT induces apoptosis in oral squamous cell carcinoma (OSCC) cells lack full clarification. Aims: This study aimed to evaluate the role of PPT in inducing apoptosis in OSCC cells by targeting signal transducer and activator of transcription 3 (STAT3) and to investigate the underlying molecular pathways. Methods: Human OSCC cell lines (HN22 and HSC4) were treated with PPT. Cell viability, colony formation, and apoptotic… More >

Jannatul Naim¹, Sheikh Mahfuja Khatun¹, Biswajit Das¹, Mumtarin Haque Mim^1,2, Sadia Akter¹, Masudur Reza Shakil³, Habibul Bari Shozib⁴, Kristina Toderich⁵, Mohammad Anwar Hossain^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3443-3463, 2024, DOI:10.32604/phyton.2024.058786 - 31 December 2024

Abstract Quinoa (Chenopodium quinoa Willd.) is regarded as a superfood due to its exceptionally high nutritional value and ability to withstand stress. Six quinoa genotypes (viz., SAU Quinoa-1, Regalona, GPBQ-1, GPBQ-2, GPBQ-3, and GPBQ-4) were characterized for morphological, yield, and nutritional quality attributes while being grown under the agro-climatic conditions of Bangladesh. The field experiment was carried out in the winter season (November 2022–March 2023) at the Agronomy Field Laboratory of the Department of Agronomy, Bangladesh Agricultural University, Mymensingh, using a randomized complete block design with three replications. Data on various qualitative and quantitative traits related to… More >

Bojana Z. Jadranin¹, Marija V. Ćosić¹, Djordje P. Božović¹, Milorad M. Vujičić^1,2, Beáta Papp³, Aneta D. Sabovljević^1,2, Marko S. Sabovljević^1,2,4,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3039-3054, 2024, DOI:10.32604/phyton.2024.058469 - 30 November 2024

Abstract The rare and threatened semi-aquatic moss Drepanocladus lycopodioides (Amblystegiaceae) was the subject of growth optimization under ex situ axenic laboratory conditions. The positioning of the plantlets on media, media types as well as selected growth regulators and sugars were parameters tested in optimizing growth promotion of this species in captivity. Out of the tested media types, the KNOP medium and the upright positioning of the explants were the best for propagation and biomass production of D. lycopodioides. The addition of sugars had no significant effect on this moss development axenically, while exogenously applied Benzylaminopurine (BAP) at a… More >

Chunxiu Ji¹, Dan Xie^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012592

Abstract The persistence of accidents attributed to structural damage in traditional rotor blades remains a pressing concern for aeronautical experts. Given the infrequency of flutter in undamaged blades, this study directs its attention to a rotor blade afflicted with structural damage, with a primary objective of discerning flutter occurrences, elucidating underlying mechanisms, and scrutinizing resultant aeroelastic responses. This paper presents an investigation into the flutter mechanism observed in transonic rotor blades subjected to structural damage, employing the Spectral Proper Orthogonal Decomposition(SPOD) method. The study aims to understand the dynamics of flutter under the influence of structural More >

Asmat Askar^1,#, Humaira Gul^1,#, Mamoona Rauf¹, Muhammad Arif², Bokyung Lee³, Sajid Ali^4,*, Abdulwahed Fahad Alrefaei⁵, Mikhlid H. Almutairi⁵, Zahid Ali Butt⁶, Ho-Youn Kim⁷, Muhammad Hamayun^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2455-2478, 2024, DOI:10.32604/phyton.2024.054508 - 30 September 2024

Abstract Drought stress negatively impacts agricultural crop yields. By using mineral fertilizers and chemical regulators to encourage plant development and growth, its impact can be mitigated. The current study revealed that exogenous silicon (Si) (potassium silicate; K₂Si₂O₅ at 1000 ppm) and molybdenum (Mo) (ammonium molybdate; (NH₄)₆Mo₇O₂4•4H₂O at 100 ppm) improved drought tolerance in quinoa (Chenopodium quinoa Willd). The research was conducted in a randomized complete block design with three biological replicates. The treatments comprised T0 (control, water spray), T4 (drought stress), and T1, T2, T3, T5, T6, and T7, i.e., foliar applications of silicon and molybdenum solutions individually… More >

YU TANG¹, WENXIAO HU^2,*, YAJUN PENG¹, XIANGDONG LING²

BIOCELL, Vol.48, No.10, pp. 1503-1516, 2024, DOI:10.32604/biocell.2024.052692 - 02 October 2024

Abstract Background: Podocyte injury is crucial in diabetic kidney disease (DKD) progression, and the mechanism remains unclear. The previous studies indicated Diosgenin played a key role in inhibiting podocyte injury progression. However, more research is needed to explore Diosgenin in inhibiting-molecular mechanisms in the process of podocyte injury. Methods: The content of Diosgenin in HeShenwan was detected by High-Performance Liquid Chromatography-mass spectrometry (HPLC-MS) method. The podocyte injury model was constructed by high glucose (HG)-induced mpc5 cells. The Cell Counting Kit-8 (CCK-8) assay was utilized to evaluate the activity of mpc5 cells. Pyroptosis in mpc5 cells was… More > Graphic Abstract

Abdel Aziz Osséni¹, Gbodja Houéhanou François Gbesso^1,*, Sedami Igor Armand Yevide², Etienne Romaric Adéwalé Godonou¹

Revue Internationale de Géomatique, Vol.33, pp. 201-220, 2024, DOI:10.32604/rig.2024.053500 - 11 July 2024

Abstract Urban green areas play a vital role in enhancing the social balance, resilience, and environmental sustainability of urban settings. In Benin, while the landscaping sector is expanding, finding appropriate locations for creating green spaces remains a challenge. The purpose of this study was to identify areas conducive to the incorporation of green landscapes into urban planning within the Sèmè-Podji District. The approach used involved a multi-criteria analysis leveraging a combined GIS and Analytic Hierarchy Process (AHP) framework. Six key factors were considered: land use, elevation, slope, distance to major roads, proximity to urban hubs, and… More > Graphic Abstract