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  • Open Access

    ARTICLE

    Quercetin regulates depression-like behavior in CUMS rat models via TLR4/NF-κB signaling

    YUANYUAN LI1, BITAO ZHANG1, ZILONG CUI1, PEIJIAN FAN1, SHAOXIAN WANG1,2,*

    BIOCELL, Vol.48, No.5, pp. 731-744, 2024, DOI:10.32604/biocell.2024.048820

    Abstract Background: Depression is becoming increasingly prevalent around the world, imposing a substantial burden on individuals, families, as well as society. Quercetin is known to be highly effective in treating depression. However, additional research is needed to dissect the mechanisms of its anti-depressive effects. Methods: For this study, Sprague-Dawley (SD) rats were randomized into the control, model, quercetin, or fluoxetine group. The latter three groups were exposed to chronic unpredictable mild stress (CUMS) for 42 d. The first two groups received saline solution daily via oral gavage. Meanwhile, the quercetin group was orally administered a quercetin suspension (52.08 mg/kg) every day,… More >

  • Open Access

    ARTICLE

    Factor Structure and Longitudinal Invariance of the CES-D across Diverse Residential Backgrounds in Chinese Adolescents

    Yanjing Cao1, Chenchen Xu1,2, Qi Li1, Shan Lu1,2,*, Jing Xiao1,*

    International Journal of Mental Health Promotion, Vol.26, No.4, pp. 261-269, 2024, DOI:10.32604/ijmhp.2024.043729

    Abstract Background: Valid and reliable measures of depressive symptoms are crucial for understanding risk factors, outcomes, and interventions across rural and urban settings. Despite this need, the longitudinal invariance of these measures over time remains understudied. This research explores the structural components of the Center for Epidemiological Studies Depression Scale (CES-D) and examines its consistency across various living environments and temporal stability in a cohort of Chinese teenagers. Method: In the initial phase, 1,042 adolescents furnished demographic details and undertook the CES-D assessment. After a three-month interval, 967 of these participants repeated the CES-D evaluation. The study employed Confirmatory factor analysis… More >

  • Open Access

    ARTICLE

    FLOWERING LOCUS T (FT) in Photosensitive Type Chrysanthemum Accelerates Flowering in Arabidopsis

    Fenglan Wang#, Zhenyuan Cai#, Zhimei Li, Shilong Zhang, Honghui Luo, Qing Wu, Hanhan Xia, Yanhong Guo*

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 819-830, 2024, DOI:10.32604/phyton.2024.049150

    Abstract FLOWERING LOCUS T (FT) is an important factor for integrating flowering signals through the photoperiod pathway, which significantly promotes flowering. Most chrysanthemum varieties are short-day plants, sensitive to the photoperiod, which limits their ornamental and annual production supply. In this study, we aim to analyze the nutrients and flowering-related genes of chrysanthemums with different photoperiod types and to clone and verify the function of the flowering-related gene CmFT. We found that the formation of floral buds requires the accumulation of starch while consuming soluble sugars and the expression patterns of flowering-related genes GIGANTEA (GI), CONSTANS (CO), and FT in C.morifoliumMore >

  • Open Access

    ARTICLE

    Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. Y. Li

    Jiaqi Lang1, Mingyan Ye1, Ya Luo1, Yueheng Wang1, Zhifen Shi1,2, Xiaotian Kong1,3, Xuan Li1, Nong Zhou1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 789-806, 2024, DOI:10.32604/phyton.2024.049088

    Abstract This study aimed to examine the effects of inoculating Fritillaria taipaiensis P.Y.Li leaves with different strains of potassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiological and biochemical characteristics. At present, some studies have only studied the rhizosphere microbial community characteristics of F. taipaiensis and have not discussed the effects of different microbial species on the growth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria to conduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October 2022. The growth of F. taipaiensis leaves… More >

  • Open Access

    ARTICLE

    E2E-MFERC: A Multi-Face Expression Recognition Model for Group Emotion Assessment

    Lin Wang1, Juan Zhao2, Hu Song3, Xiaolong Xu4,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1105-1135, 2024, DOI:10.32604/cmc.2024.048688

    Abstract In smart classrooms, conducting multi-face expression recognition based on existing hardware devices to assess students’ group emotions can provide educators with more comprehensive and intuitive classroom effect analysis, thereby continuously promoting the improvement of teaching quality. However, most existing multi-face expression recognition methods adopt a multi-stage approach, with an overall complex process, poor real-time performance, and insufficient generalization ability. In addition, the existing facial expression datasets are mostly single face images, which are of low quality and lack specificity, also restricting the development of this research. This paper aims to propose an end-to-end high-performance multi-face expression recognition algorithm model suitable… More >

  • Open Access

    ARTICLE

    Expression Recognition Method Based on Convolutional Neural Network and Capsule Neural Network

    Zhanfeng Wang1, Lisha Yao2,*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1659-1677, 2024, DOI:10.32604/cmc.2024.048304

    Abstract Convolutional neural networks struggle to accurately handle changes in angles and twists in the direction of images, which affects their ability to recognize patterns based on internal feature levels. In contrast, CapsNet overcomes these limitations by vectorizing information through increased directionality and magnitude, ensuring that spatial information is not overlooked. Therefore, this study proposes a novel expression recognition technique called CAPSULE-VGG, which combines the strengths of CapsNet and convolutional neural networks. By refining and integrating features extracted by a convolutional neural network before introducing them into CapsNet, our model enhances facial recognition capabilities. Compared to traditional neural network models, our… More >

  • Open Access

    ARTICLE

    Enhancing Cancer Classification through a Hybrid Bio-Inspired Evolutionary Algorithm for Biomarker Gene Selection

    Hala AlShamlan*, Halah AlMazrua*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 675-694, 2024, DOI:10.32604/cmc.2024.048146

    Abstract In this study, our aim is to address the problem of gene selection by proposing a hybrid bio-inspired evolutionary algorithm that combines Grey Wolf Optimization (GWO) with Harris Hawks Optimization (HHO) for feature selection. The motivation for utilizing GWO and HHO stems from their bio-inspired nature and their demonstrated success in optimization problems. We aim to leverage the strengths of these algorithms to enhance the effectiveness of feature selection in microarray-based cancer classification. We selected leave-one-out cross-validation (LOOCV) to evaluate the performance of both two widely used classifiers, k-nearest neighbors (KNN) and support vector machine (SVM), on high-dimensional cancer microarray… More >

  • Open Access

    ARTICLE

    Contrastive Consistency and Attentive Complementarity for Deep Multi-View Subspace Clustering

    Jiao Wang, Bin Wu*, Hongying Zhang

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 143-160, 2024, DOI:10.32604/cmc.2023.046011

    Abstract Deep multi-view subspace clustering (DMVSC) based on self-expression has attracted increasing attention due to its outstanding performance and nonlinear application. However, most existing methods neglect that view-private meaningless information or noise may interfere with the learning of self-expression, which may lead to the degeneration of clustering performance. In this paper, we propose a novel framework of Contrastive Consistency and Attentive Complementarity (CCAC) for DMVsSC. CCAC aligns all the self-expressions of multiple views and fuses them based on their discrimination, so that it can effectively explore consistent and complementary information for achieving precise clustering. Specifically, the view-specific self-expression is learned by… More >

  • Open Access

    ARTICLE

    miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK

    XIAOXI WANG1, YANFEI JIA2, QIANG LI2, QIANG YANG2, YINGFENG LIU1, BEIFENG WEI1, XIANG NIU1, YINJIE ZHANG1, XIAODONG LUO2, ZIYU ZHAO1,*, PENG WANG1,*

    Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581

    Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >

  • Open Access

    ARTICLE

    Finite Element Simulations of the Localized Failure and Fracture Propagation in Cohesive Materials with Friction

    Chengbao Hu1,2,3, Shilin Gong4,*, Bin Chen1,2,3, Zhongling Zong4, Xingwang Bao5, Xiaojian Ru5

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 997-1015, 2024, DOI:10.32604/cmes.2024.048640

    Abstract Strain localization frequently occurs in cohesive materials with friction (e.g., composites, soils, rocks) and is widely recognized as a fundamental cause of progressive structural failure. Nonetheless, achieving high-fidelity simulation for this issue, particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones, remains significantly constrained. In response, this study introduces an integrated algorithm within the finite element framework, merging a coupled cohesive zone model (CZM) with the nonlinear augmented finite element method (N-AFEM). The coupled CZM comprehensively describes tension-compression and compression-shear failure behaviors in cohesive, frictional materials, while the N-AFEM allows nonlinear coupled intra-element discontinuities without necessitating extra nodes or… More >

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