Ranjit Philip¹, Jeffrey A. Towbin¹, Shyam Sathanandam ¹, Jason Goldberg¹, Thomas Yohannan¹, Nithya Swaminathan¹, Jason Nathaniel Johnson^1,2

Congenital Heart Disease, Vol.14, No.1, pp. 33-36, 2019, DOI:10.1111/chd.12701

Abstract There continues to be controversy on the long‐term effects of a patent ductus arte‐ riosus (PDA) and its management. However, the hemodynamic effects of a large PDA in a preterm infant are well known. This article aims to provide insight into the adap‐ tive changes and remodeling effects of a PDA on the myocardium in preterm infants. More >

Thittamaranahalli Kariyappa Susheel Kumar

Congenital Heart Disease, Vol.14, No.1, pp. 57-59, 2019, DOI:10.1111/chd.12699

Abstract Surgical ligation of patent ductus arteriosus can be performed safely by following standard steps of operation. Familiarity of the anatomical landmarks and simple pre‐ cautions result in high degree of safety. The technique of surgical ligation varies with the age of the patient. Surgical ligation of ductus is associated with well‐recognized complications, although they occur only in a small number of patients. More >

Kent A. Willis, Mark F. Weems

Congenital Heart Disease, Vol.14, No.1, pp. 27-32, 2019, DOI:10.1111/chd.12691

Abstract Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. We describe preclinical and clinical data demonstrating the association of a PDA… More >