Shakra Mehak¹, M. Usman Ashraf², Rabia Zafar³, Ahmed M. Alghamdi⁴, Ahmed S. Alfakeeh⁵, Fawaz Alassery⁶, Habib Hamam⁷, Muhammad Shafiq^8,*

CMC-Computers, Materials & Continua, Vol.71, No.2, pp. 3407-3423, 2022, DOI:10.32604/cmc.2022.022705

Abstract Breast cancer (BC) is the most widely recognized cancer in women worldwide. By 2018, 627,000 women had died of breast cancer (World Health Organization Report 2018). To diagnose BC, the evaluation of tumours is achieved by analysis of histological specimens. At present, the Nottingham Bloom Richardson framework is the least expensive approach used to grade BC aggressiveness. Pathologists contemplate three elements, 1. mitotic count, 2. gland formation, and 3. nuclear atypia, which is a laborious process that witness's variations in expert's opinions. Recently, some algorithms have been proposed for the detection of mitotic cells, but nuclear atypia in breast cancer… More >

SEAN J. O’SULLIVAN^1,2,*

BIOCELL, Vol.46, No.1, pp. 7-11, 2022, DOI:10.32604/biocell.2022.017680

Abstract The development of effective treatments for psychiatric disease has been disappointing in recent decades given the advancements in neuroscience. Moreover, rising rates of mental illness such as addiction and depression compel scientists and physicians to discover novel and creative solutions. One such approach that has proven effective is systems neuroscience: A focus on networks as opposed to mechanism. Further, investigation at the single-cell and circuit level is likely to be fruitful in such endeavors as this resolution describes the functional psychopathology that allows for intervention. More >

Prabhakaran Mathialagan^*, Malathy Chidambaranathan

Intelligent Automation & Soft Computing, Vol.31, No.2, pp. 929-946, 2022, DOI:10.32604/iasc.2022.020163

Abstract Nasal cavity and paranasal sinus tumours that occur in the respiratory tract are the most life-threatening disease in the world. The human respiratory tract has many sites which has different mucosal lining like frontal, parred, sphenoid and ethmoid sinuses. Nasal cavity tumours can occur at any different mucosal linings and chances of prognosis possibility from one nasal cavity site to another site is very high. The paranasal sinus tumours can metastases to oral cavity and digestive tracts may lead to excessive survival complications. Grading the respiratory tract tumours with dysplasia cases are more challenging using manual pathological procedures. Manual microscopic… More >

VERA KOLYOVSKA^1,#, SONYA IVANOVA², DESISLAVA DRENSKA³, DIMITAR MASLAROV^3,4,#, RENETA TOSHKOVA^1,*

BIOCELL, Vol.45, No.6, pp. 1485-1494, 2021, DOI:10.32604/biocell.2021.016250

Abstract Glycosphingolipids (gangliosides) have been characterized as important biological molecules with a key role as regulators in many physiological processes on cellular, tissue, organ, and organism levels. The deviations in their normal amounts, production, and metabolism are very often related to the development of many multi-factor socially important diseases. GM3 ganglioside, as a small molecule, plays important roles in the cascade regulatory pathways in the pathology of many disorders like neurodegenerative diseases, autoimmune diseases, inflammation, diabetes, malignant transformation, and others. Ganglioside GM3 and its derivatives are membrane-bound glycosphingolipids composed of an oligosaccharide head structure containing one sialic acid residue. These molecules… More >

Jinyang Liu¹, Xianchao Jiang¹, Runsi Wang², Li Li³, Ju Zhao⁴, Fuxia Yan⁵, Run Yuan⁶, Qiang Wang^1,*

Congenital Heart Disease, Vol.16, No.3, pp. 245-254, 2021, DOI:10.32604/CHD.2021.014881

Abstract Background: Never had literatures characterized the relationship between the property of major aortopulmonary collateral arteries (MAPCAs) and outcomes of selective unifocalization of pulmonary atresia with ventricular septal defects and MAPCAs. Methods: This is a case-series study. Thirteen patients were included. Angiography-based assessment was conducted to determine whether collateral arteries should be unifocalized or treated with intraoperative ligature. Specimens were collected and stained by HE and ET+VG. Results: Twelve patients underwent one-stage unifocalization at a median age of 37 months (range: 6–228 months) and a median weight of 14.0 kg (range: 5.0–49.0 kg), which produced a favorable right ventricle to aortic… More >

Afzan Adam^1,*, Abdul Hadi Abd Rahman¹, Nor Samsiah Sani¹, Zaid Abdi Alkareem Alyessari¹, Nur Jumaadzan Zaleha Mamat², Basela Hasan³

CMC-Computers, Materials & Continua, Vol.67, No.1, pp. 761-777, 2021, DOI:10.32604/cmc.2021.014599

Abstract Boundary effect in digital pathology is a phenomenon where the tissue shapes of biopsy samples get distorted during the sampling process. The morphological pattern of an epithelial layer is greatly affected. Theoretically, the shape deformation model can normalise the distortions, but it needs a 2D image. Curvatures theory, on the other hand, is not yet tested on digital pathology images. Therefore, this work proposed a curvature detection to reduce the boundary effects and estimates the epithelial layer. The boundary effect on the tissue surfaces is normalised using the frequency of a curve deviates from being a straight line. The epithelial… More >

Sophie Gardrat^*, Vincent Cockenpot

Oncologie, Vol.22, No.4, pp. 195-202, 2020, DOI:10.32604/oncologie.2020.013698

Abstract The pathological examination of ocular tumors has specificities in terms of macroscopic management, microscopic analysis, and molecular examinations requiring special attention. We discuss here the difficulties encountered in the reception in the pathological anatomy laboratory of conjunctival samples, enucleation and orbital exenteration pieces, then detail the diagnostic and theranostic, microscopic and molecular characteristics of ocular tumor pathologies. Conjunctival tumors (epithelial, melanocytic and lymphoid), choroidal tumors (including uveal melanoma) and retinoblastoma are treated. Because of their low frequency and their features, these tumors should be the subject of anatomo-clinical discussions.

Résumé:
L’examen anatomopathologique des tumeurs oculaires comporte des spécificités en termes… More >

Burcu BİTERGE SÜT^1,*, Ayşe İKİNCİ KELE޲

Oncologie, Vol.22, No.3, pp. 147-154, 2020, DOI:10.32604/oncologie.2020.014449

Abstract Components of the protein synthesis machinery are subjected to alterations in cancer cells. eEF1D gene, which lies within the frequently amplified 8q24 locus, is one of the subunits of the human eukaryotic elongation factor complex. This study aimed to evaluate the prognostic and predictive significance of eEF1D in breast cancer using in silico analysis tools. For this purpose, we analyzed genomic alterations of the eEF1D gene using TCGA datasets via cBioPortal. Histopathological analysis was performed on patient tissue images obtained from cBioPortal and the Human Protein Atlas. Survival analysis was carried out using the KM Plotter and the prediction of… More >

Katie E. Cohen¹, Matthew W. Buelow¹, Jennifer Dixon¹, Ruta Brazauskas², Scott B. Cohen³, Michael G. Earing^1,3, Salil Ginde¹

Congenital Heart Disease, Vol.12, No.4, pp. 435-440, 2017, DOI:10.1111/chd.12470

Abstract Objective: Abnormal lung function characterized by a reduced forced vital capacity (FVC) is common in adults with repaired tetralogy of Fallot (TOF) and is associated with previous thoracotomies and sternotomies. The impact of abnormal lung function on clinical outcomes in adult patients with repaired TOF is unclear. The aim of this study was to determine the impact of abnormal lung function on the outcome of hospitalization and death in adults with repaired TOF when analyzed with other traditional cardiac risk factors.
Design: Retrospective study of adults with repaired TOF, who underwent spirometry between 2000 and 2014. FVC < 60% of… More >

Lidia R. Bons¹, Lucas Uchoa de Assis¹, Silvy Dekker¹, Robert M. Kauling¹, Judith A.A.E. Cuypers¹, Hence J.M. Verhagen², Ricardo P.J. Budde³, Jolien W. Roos‐Hesselink¹

Congenital Heart Disease, Vol.13, No.6, pp. 988-996, 2018, DOI:10.1111/chd.12663

Abstract Objective: The aim is to present current clinical practice of thoracic aorta screening in a tertiary referral center. We identified how often imaging techniques were used for screening and established the value of transthoracic echocardiography (TTE) in com‐ parison with computed tomography (CT) to detect aortic dilation. We also investigated which additional abnormalities of the heart, aorta or smaller arteries were discovered.
Design: All patients ≥15 years who visited our tertiary center in 2012‐2016 for first thoracic aortic screening were retrospectively included. Diameters of the sinus of Valsalva (SoV) and maximum ascending aorta (AA) were compared between TTE and CT.… More >