Mee-Young Ahn*1, Hyo-Eun Yoon†1, Seong-Yong Moon‡, Yong-Chul Kim§, Jung-Hoon Yoon†
Oncology Research, Vol.25, No.2, pp. 295-304, 2017, DOI:10.3727/096504016X14732527645922
Abstract Photodynamic therapy (PDT) is a therapeutic alternative for malignant tumors that uses a photosensitizer. Our
group recently synthesized photosensitizer pheophorbide a (Pa) from chlorophyll-a. The present study investigated the therapeutic effect of PDT using intratumoral administration of the synthetic photosensitizer Pa in
an in vivo murine oral squamous cell carcinoma (OSCC) animal model. Pa accumulation was measured using
the fluorescence spectrum and imaging in living C3H mice. Intratumoral treatment of Pa-PDT (IT Pa-PDT)
significantly inhibited the growth of transplanted OSCC cells. Histopathological examination of tumor tissues showed that PCNA expression was significantly decreased, while TUNEL-stained… More >
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