Jingnan Zhang¹, Junyi Wan¹, Yihang Li², Yu Han², Jiahua Pan³, Fang Fang¹, Shiliang Jiang⁴, Xiangbin Pan¹, Gejun Zhang^1,*

Congenital Heart Disease, Vol.18, No.2, pp. 219-234, 2023, DOI:10.32604/chd.2023.027562

Abstract Background: The Venus-P valve was the first self-expanding valve used world-wide for transcatheter pulmonary valve replacement (TPVR) in patients with severe pulmonary regurgitation (PR). We intended to report the extended follow-up results from the prospective trial (No. NCT02590679). Methods: A total of 38 patients with severe PR (mean age 24.2 ± 13.2) were included. Follow-up data were obtained after implanted at 1, 6, and 12 months and yearly after. The frame geometry was assessed on post-implant computer tomography (CT) scanning by calculating the non-circularity [circularity ratio (minimum diameter/maximum diameter) < 0.9] and under-expansion [expansion ratio (derived external valve area/nominal external valve area)… More > Graphic Abstract

Woo Young Park¹, Gi Beom Kim^1,*, Sang Yun Lee¹, Mi Kyoung Song¹, Hye Won Kwon¹, Hyo Soon An¹, Eun Jung Bae¹, Sungkyu Cho², Jae Gun Kwak², Woong-Han Kim²

Congenital Heart Disease, Vol.17, No.3, pp. 335-350, 2022, DOI:10.32604/chd.2022.018666

Abstract Objectives: To establish long-term outcome of surgical pulmonary valve replacement (PVR) in congenital heart disease (CHD) and to identify risk factors for overall mortality, operative mortality, and repetitive PVR. Methods: This is a retrospective study of 375 surgical PVR in 293 patients who underwent surgical PVR for CHD between January 2000 and May 2020. We only included patients with index PVR with previous open-heart surgery regardless of the number of PVRs. The previous surgical history of patients who underwent PVR during the study period was also included. Patients who underwent the Rastelli operation, and those who underwent single PVR without… More >

R. Allen Ligon^1,*, Larry A. Latson¹, Mark M. Ruzmetov², Kak-Chen Chan¹, Todd Roth¹, Immanuel I. Turner², Frank G. Scholl², Steve Bibevski²

Congenital Heart Disease, Vol.16, No.3, pp. 285-297, 2021, DOI:10.32604/CHD.2021.014373

Abstract Background: Pulmonary valve replacement (PVR) can be accomplished via surgical, transcatheter, or hybrid approaches. There are inherent advantages to transcatheter PVR and hybrid PVR without cardiopulmonary bypass. We review the methods and results of a standardized institutional approach to PVR. Methods: Retrospective review of all PVR cases between February 2017 and February 2020. Hybrid PVR entailed off-pump RVOT plication with percutaneous transcatheter PVR. Results: Primary transcatheter PVR was attempted in 37, hybrid PVR was performed in 11, and on-pump surgical PVR was performed in 9. Median age at PVR was 27 years (6–65). Primary transcatheter PVR was successful in 35/37… More >

Clotilde Kingsley¹, Saad Ahmad², John Pappachan¹, Sujata Khambekar¹, Thomas Smith¹, Diane Gardiner¹, James Shambrook¹, Shankar Baskar³, Ryan Moore³, Gruschen Veldtman³

Congenital Heart Disease, Vol.13, No.2, pp. 288-294, 2018, DOI:10.1111/chd.12569

Abstract Background: The right ventricular (RV) contractile reserve is a measure of the dynamic function of the RV and is a sensitive indicator of volume load. This can be measured noninvasively using the tricuspid annular plane systolic excursion (TAPSE) during exercise. We studied the RV contractile reserve of patients after tetralogy of Fallot (TOF) repair with varying degree of RV dilation and pulmonary regurgitation (PR), and compared them to a control group.
Methods: Twenty-six patients who had undergone TOF repair (mean age 29 ± 10 years) were identified and stratified into three group based on the presence and severity of RV… More >

Wendy F. Li¹, Heidi Pollard², Mohsen Karimi³, Jeremy D. Asnes¹, William E. Hellenbrand¹, Veronika Shabanova⁴, Constance G. Weismann^1,5

Congenital Heart Disease, Vol.13, No.1, pp. 140-146, 2018, DOI:10.1111/chd.12544

Abstract Objective: Trans-catheter (TC) pulmonary valve replacement (PVR) has become common practice for patients with right ventricular outflow tract obstruction (RVOTO) and/or pulmonic insufficiency (PI). Our aim was to compare PVR and right ventricular (RV) function of patients who received TC vs surgical PVR.
Design: Retrospective review of echocardiograms obtained at three time points: before, immediately after PVR, and most recent.
Patients: Sixty-two patients (median age 19 years, median follow-up 25 months) following TC (N = 32) or surgical (N = 30) PVR at Yale-New Haven Hospital were included.
Outcome Measures: Pulmonary valve and right ventricular function before, immediately after, and… More >

Subeer K. Wadia¹, Gentian Lluri¹, Jamil A. Aboulhosn¹, Hillel Laks², Reshma M. Biniwale², Glen S. Van Arsdell², Daniel S. Levi³, Morris M. Salem³, Kevin M. Shannon^1,3, Jeremy P. Moore^1,3

Congenital Heart Disease, Vol.14, No.5, pp. 838-845, 2019, DOI:10.1111/chd.12818

Abstract Objective: We examined the atrial tachyarrhythmia (AT) burden among patients with congenital heart disease (CHD) following transcatheter (TC‐) or surgical (S‐) pulmo‐ nary valve replacement (PVR).
Design/Setting: This was a retrospective observational study of patients who under‐ went PVR from 2010 to 2016 at UCLA Medical Center.
Patients: Patients of all ages who had prior surgical repair for CHD were included. Patients with a history of congenitally corrected transposition of the great arteries, underwent a hybrid PVR procedure, or had permanent atrial fibrillation (AF) without a concomitant ablation were excluded.
Outcome Measures: The primary outcome was a time‐to‐event analysis of… More >

Han Yu¹, Pedro J. del Nido², Tal Geva³, Chun Yang⁴, Zheyang Wu⁴, Rahul H. Rathod³, Xueying Huang⁵, Kristen L. Billiar⁶, Dalin Tang^1,4,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 73-74, 2019, DOI:10.32604/mcb.2019.05837

Abstract Ventricle mechanical stress and strain calculations play an important role in cardiovascular investigations. Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricular (RV) failure. The current surgical approach, including pulmonary valve replacement(PVR), has yielded mixed results with some patients recover RV function after pulmonary valve insertion with or without concomitant RV remodeling surgery but some do not[Therrien, Siu and McLaughlin (2000);]. Cardiac magnetic resonance (CMR) data were collected from 6 healthy volunteers and 12 Tetralogy of Fallot (TOF) patients before PVR with consent obtained. 12 patients were divided into two groups… More >

Zhedian Zhou¹, Tal Geva², Rahul H. Rathod², Alexander Tang², Chun Yang³, Kristen L. Billiar⁴, Dalin Tang^1,*,3, Pedro del Nido⁵

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 99-115, 2018, DOI: 10.3970/mcb.2018.00558

Abstract Patients with repaired Tetralogy of Fallot (ToF), a congenital heart defect which includes a ventricular septal defect and severe right ventricular outflow obstruction, account for the majority of cases with late onset right ventricle (RV) failure. The current surgical approach, which includes pulmonary valve replacement/insertion (PVR), has yielded mixed results. A computational parametric study using 7 patient-specific RV/LV models based on cardiac magnetic resonance (CMR) data as "virtual surgery" was performed to investigate the impact of patch size, RV remodeling and tissue regeneration in PVR surgery design on RV cardiac functions. Two patch sizes, three degrees of scar trimming (RV… More >