Jihong Sun*†1, Jingjing Li†1, Zhixian Guo†, Lu Sun†‡, Chenghui Juan§, Yubing Zhou¶, Hongli Gu†, Yan Yu†, Qiuyue Hu†, Quancheng’ Kan¶, Zujiang Yu†
Oncology Research, Vol.27, No.4, pp. 407-417, 2019, DOI:10.3727/096504018X15180451872087
Abstract Most cancers rely disproportionately on glycolysis for energy even in the presence of an adequate oxygen
supply, a condition known as “aerobic glycolysis,” or the “Warburg effect.” Pyruvate dehydrogenase E1 subunit (PDHA1) is one of the main factors for the metabolic switch from oxidative phosphorylation (OXPHOS)
to aerobic glycolysis and has been suggested to be closely associated with tumorigenesis. Here we observed
that the PDHA1 protein was reduced in hepatocellular carcinoma (HCC) specimens by immunohistochemistry
and Western blot, which was significantly associated with poor overall survival. To further analyze the function of PDHA1 in cancer cells, PDHA1 was upregulated in… More >
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