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  • Open Access

    ARTICLE

    Two Eras of Despair: A Long-Term Trend Analysis of Deaths of Despair in Central and Eastern Europe and Central Asia

    Eun Hae Lee1,2,3, Minjae Choi4,5, Hanul Park3,6, Joon Hee Han3,6,7, Sujeong Yu3,8, Joshua Kirabo Sempungu1,2,3,6, Inbae Sohn4,6, Yo Han Lee3,6,*

    International Journal of Mental Health Promotion, Vol.28, No.1, 2026, DOI:10.32604/ijmhp.2025.073735 - 28 January 2026

    Abstract Background: That Central and Eastern Europe and Central Asia (CEECA) experienced a major mortality crisis in the 1990s is a well-established finding, with most analyses focusing on singular causes like alcohol-related deaths. However, the utility of the integrated “deaths of despair” framework, which views alcohol, drug, and suicide deaths as a unified socio-economic phenomenon, remains under-explored in this context. Crucially, the long-term evolution of the composition of despair within the region remains a largely unexplored area of inquiry. Therefore, this study aims to analyze the long-term trends, changing composition, and regional heterogeneity of deaths from despair… More >

  • Open Access

    REVIEW

    Parasitic Infections and Carcinogenesis: Molecular Mechanisms, Immune Modulation, and Emerging Therapeutic Strategies

    Marta Pawłowska1,*, Dorian Jarek2, Jan Milanowski2, Karolina Szewczyk-Golec1

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071891 - 19 January 2026

    Abstract Parasitic infections are increasingly recognized as contributors to cancer development, yet the underlying oncogenic mechanisms remain insufficiently understood. Growing evidence from molecular oncology, immunology, and microbiome research suggests that chronic parasitic infections may drive tumorigenesis through sustained inflammation, deregulated signaling pathways, genomic instability, and the release of parasite-derived exosomes that reshape the tumor microenvironment. These insights underscore the need to integrate parasitology with cancer biology to understand infection-associated malignancies better. The aim of this narrative review is to synthesize current knowledge on how selected parasites contribute to cancer development and to highlight emerging therapeutic and… More > Graphic Abstract

    Parasitic Infections and Carcinogenesis: Molecular Mechanisms, Immune Modulation, and Emerging Therapeutic Strategies

  • Open Access

    ARTICLE

    Detection of KRAS, NRAS and BRAF Mutations in Liquid Biopsy from Patients with Colorectal Cancer

    Katerina Ondraskova1,2, Matous Cwik3, Ondrej Horky4, Jitka Berkovcova4, Jitka Holcakova1, Martin Bartosik1, Tomas Kazda5, Klara Mrazova1,6, Michal Uher7, Igor Kiss3, Roman Hrstka1,3,*

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070116 - 19 January 2026

    Abstract Objectives: Cancer treatment relies heavily on accurate diagnosis and effective monitoring of the disease. These processes often involve invasive procedures, such as colonoscopy, to detect malignant tissues, followed by molecular analyses to determine relevant biomarkers. This study aimed to evaluate the clinical performance of droplet digital PCR (ddPCR) for detecting Kirsten Rat Sarcoma Viral Proto-Oncogene (KRAS), Neuroblastoma RAS Viral Oncogene Homolog (NRAS), and B-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations in circulating tumor DNA (ctDNA) from colorectal cancer patients using liquid biopsy. Methods: ctDNA was isolated from colorectal cancer (CRC) patients (n = 110) and analyzed for KRAS, BRAF,… More >

  • Open Access

    ARTICLE

    CamSimXR: eXtended Reality (XR) Based Pre-Visualization and Simulation for Optimal Placement of Heterogeneous Cameras

    Juhwan Kim1, Gwanghyun Jo2, Dongsik Jo1,*

    CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072664 - 12 January 2026

    Abstract In recent years, three-dimensional reconstruction technologies that employ multiple cameras have continued to evolve significantly, enabling remote collaboration among users in extended Reality (XR) environments. In addition, methods for deploying multiple cameras for motion capture of users (e.g., performers) are widely used in computer graphics. As the need to minimize and optimize the number of cameras grows to reduce costs, various technologies and research approaches focused on Optimal Camera Placement (OCP) are continually being proposed. However, as most existing studies assume homogeneous camera setups, there is a growing demand for studies on heterogeneous camera setups.… More >

  • Open Access

    ARTICLE

    EARAS: An Efficient, Anonymous, and Robust Authentication Scheme for Smart Homes

    Muntaham Inaam Hashmi1, Muhammad Ayaz Khan2, Khwaja Mansoor ul Hassan1, Suliman A. Alsuhibany3,*, Ainur Abduvalova4, Asfandyar Khan5

    CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.071452 - 12 January 2026

    Abstract Cyber-criminals target smart connected devices for spyware distribution and security breaches, but existing Internet of Things (IoT) security standards are insufficient. Major IoT industry players prioritize market share over security, leading to insecure smart products. Traditional host-based protection solutions are less effective due to limited resources. Overcoming these challenges and enhancing the security of IoT Devices requires a security design at the network level that uses lightweight cryptographic parameters. In order to handle control, administration, and security concerns in traditional networking, the Gateway Node offers a contemporary networking architecture. By managing all network-level computations and… More >

  • Open Access

    ARTICLE

    A Novel Quantitative Detection of Sleeve Grouting Compactness Based on Ultrasonic Time-Frequency Dual-Domain Analysis

    Longqi Liao1, Jing Li2, Yuhua Li3, Yuemin Wang3, Jinhua Li1,*, Liyuan Cao4,*, Chunxiang Li4,*

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.072237 - 08 January 2026

    Abstract Quantitative detection of sleeve grouting compactness is a technical challenge in civil engineering testing. This study explores a novel quantitative detection method based on ultrasonic time-frequency dual-domain analysis. It establishes a mapping relationship between sleeve grouting compactness and characteristic parameters. First, this study made samples with gradient defects for two types of grouting sleeves, G18 and G20. These included four cases: 2D, 4D, 6D defects (where D is the diameter of the grouting sleeve), and no-defect. Then, an ultrasonic input/output data acquisition system was established. Three-dimensional sound field distribution data were obtained through an orthogonal… More >

  • Open Access

    ARTICLE

    Suppression of Dry-Coupled Rubber Layer Interference in Ultrasonic Thickness Measurement: A Comparative Study of Empirical Mode Decomposition Variants

    Weichen Wang1, Shaofeng Wang1, Wenjing Liu1,*, Luncai Zhou2, Erqing Zhang1, Ting Gao3, Grigory Petrishin4

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071278 - 08 January 2026

    Abstract In dry-coupled ultrasonic thickness measurement, thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy. Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise. This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference. By decomposing A-scan signals into Intrinsic Mode Functions (IMFs), the framework employs energy contribution thresholds (>85%) and kurtosis indices (>3) to autonomously select IMFs containing valid specimen echoes. Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing. More >

  • Open Access

    ARTICLE

    Ultrasonic Defect Localization Correction Method under the Influence of Non-Uniform Temperature Field

    Jianhua Du1, Shaofeng Wang1, Ting Gao2, Huiwen Sun2, Wenjing Liu1,*

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071189 - 08 January 2026

    Abstract In ultrasonic non-destructive testing of high-temperature industrial equipment, sound velocity drift induced by non-uniform temperature fields can severely compromise defect localization accuracy. Conventional approaches that rely on room-temperature sound velocities introduce systematic errors, potentially leading to misjudgment of safety-critical components. Two primary challenges hinder current methods: first, it is difficult to monitor real-time changes in sound velocity distribution within a thermal gradient; second, traditional uniform-temperature correction models fail to capture the nonlinear dependence of material properties on temperature and their effect on ultrasonic velocity fields. Here, we propose a defect localization correction method based on… More >

  • Open Access

    ARTICLE

    AGPAT3 Regulates Immune Microenvironment in Osteosarcoma via Lysophosphatidic Acid Metabolism

    Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

    Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

  • Open Access

    REVIEW

    Curtain Wall Systems as Climate-Adaptive Energy Infrastructures: A Critical Review of Their Role in Sustainable Building Performance

    Samira Rastbod1, Mehdi Jahangiri2,*, Behrang Moradi1, Haleh Nazari1

    Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070089 - 27 December 2025

    Abstract Curtain wall systems have evolved from aesthetic façade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness. This review presents a comprehensive examination of curtain walls from an energy-engineering perspective, highlighting their structural typologies (Stick and Unitized), material configurations, and integration with smart technologies such as electrochromic glazing, parametric design algorithms, and Building Management Systems (BMS). The study explores the thermal, acoustic, and solar performance of curtain walls across various climatic zones, supported by comparative analyses and iconic case studies including Apple Park, Burj Khalifa, and Milad Tower. Key challenges—including… More > Graphic Abstract

    Curtain Wall Systems as Climate-Adaptive Energy Infrastructures: A Critical Review of Their Role in Sustainable Building Performance

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