Jingcheng Lyu^1,2,#, Ruiyu Yue^1,2,#, Yichen Zhu^1,2, Ye Tian^1,2,*, Xinyi Hu^1,2,*

Canadian Journal of Urology, Vol.32, No.5, pp. 411-422, 2025, DOI:10.32604/cju.2025.066758 - 30 October 2025

Abstract Objective: Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. Method: A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using t-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary More >

Chao Gui^1,2, Wanying Chang³, Yaping Liu^1,*, Leren Tao³, Daoming Shen¹, Mengyi Ge¹

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1621-1637, 2025, DOI:10.32604/fhmt.2025.072268 - 31 October 2025

Abstract Freeze-drying of structurally heterogeneous biomaterials such as porcine aorta presents considerable modeling challenges due to their inherent multilayer composition and moving sublimation interfaces. Conventional models often overlook structural anisotropy and dynamic boundary progression, while experimental determination of key parameters under cryogenic conditions remains difficult. To address these, this study develops a heat and mass transfer model incorporating a dynamic node strategy for the sublimation interface, which effectively handles continuous computational domain deformation. Additionally, specialized fixed nodes were incorporated to adapt to the multilayer structure and its spatially varying thermophysical properties. A novel non-contact gravimetric system More > Graphic Abstract

Abeer S. Al-Humaimeedy^*

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5207-5236, 2025, DOI:10.32604/cmc.2025.068273 - 23 October 2025

Abstract This paper presents 3RVAV (Three-Round Voting with Advanced Validation), a novel Byzantine Fault Tolerant consensus protocol combining Proof-of-Stake with a multi-phase voting mechanism. The protocol introduces three layers of randomized committee voting with distinct participant roles (Validators, Delegators, and Users), achieving -threshold approval per round through a verifiable random function (VRF)-based selection process. Our security analysis demonstrates 3RVAV provides resistance to Sybil attacks with participants and stake , while maintaining communication complexity. Experimental simulations show 3247 TPS throughput with 4-s finality, representing a 5.8× improvement over Algorand’s committee-based approach. The proposed protocol achieves approximately 4.2-s More >

Xiangnan Feng^1,#, Dayong Li^2,#, Pingyu Wang¹, Xinyu Li², Guangyao Li^2,*

Oncology Research, Vol.33, No.11, pp. 3327-3346, 2025, DOI:10.32604/or.2025.067343 - 22 October 2025

Abstract Lactylation, a post-translational modification process that adds lactate groups to lysine residues, plays a crucial role in cancer biology, especially in drug resistance. However, the specific molecular mechanisms of lactylation in cancer progression and drug resistance are still unclear, and therapeutic strategies targeting the lactylation pathway are expected to overcome metabolic reprogramming and immune evasion. Therefore, this article provides a comprehensive description and summary of lactylation modification and tumor drug resistance. Numerous studies have shown that, due to the Warburg effect, there is an abnormally high level of lactate in tumor cells. Elevated levels of… More >

Xiangyu Yan^1,#, Yusheng Jin^1,#, Yan Yuan¹, Xubaihe Zhang¹, Jiayi Li¹, Ying Xu¹, Yangyang Ge², Anqing Wu^1,*

BIOCELL, Vol.49, No.10, pp. 1929-1946, 2025, DOI:10.32604/biocell.2025.066935 - 22 October 2025

Abstract Objectives: Fractionated radiotherapy represents a standardized and widely adopted treatment modality for cancer management, with approximately 40% of non-small cell lung cancer (NSCLC) patients receiving it. However, repeated irradiation may induce radioresistance in cancer cells, reducing treatment effectiveness and raising recurrence risk. The long noncoding RNA CRYBG3 (lncRNA CRYBG3), which is upregulated in lung cancer cells after X-ray irradiation, contributes to the radioresistance of NSCLC cells by promoting wild-type p53 protein degradation. This study aims to elucidate the mechanism of fractionated irradiation-induced radioresistance, in which lncRNA CRYBG3 regulates radiation-induced mitochondrial damage and reactive oxygen species… More >

Mahim Masfikun Hannan, Deng’an Cai^*, Xinwei Wang

Journal of Polymer Materials, Vol.42, No.3, pp. 873-891, 2025, DOI:10.32604/jpm.2025.064978 - 30 September 2025

Abstract This study investigates the low-velocity impact and post-impact flexural properties of 3D integrated woven spacer composites, focusing on their orthotropic behavior when tested along two principal directions, i.e., warp (X-type) and weft (Y-type) directions. The same composite material was tested in these orientations to evaluate the differences in impact resistance and residual bending strength. Specimens were fabricated via vacuum-assisted molding and tested at 2, 3, 5, and 7 J impact energies using an Instron Ceast 9350 drop-weight impact testing machine, in accordance with ASTM D7136. Post-impact flexural tests were performed using a four-point bending method… More >

Jing Zhang^1,#, Huifen Qiao^1,#, Shenglong Wang^1,#, Jiawei Yuan¹, Qingsong Ba¹, Gensheng Zhang^1,2,*, Guiping Li^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2701-2718, 2025, DOI:10.32604/phyton.2025.070017 - 30 September 2025

Abstract Wheat stripe rust, a devastating disease caused by the fungal pathogen Puccinia striiformis f. sp. tritici (Pst), poses a significant threat to global wheat production. Growing resistant cultivars is a crucial strategy for wheat stripe rust management. However, the underlying molecular mechanisms of wheat resistance to Pst remain incompletely understood. To unravel these mechanisms, we employed high-throughput RNA sequencing (RNA-Seq) to analyze the transcriptome of the resistant wheat cultivar Mianmai 46 (MM46) at different time points (24, 48, and 96 h) post-inoculation with the Pst race CYR33. The analysis revealed that Pst infection significantly altered the expression of genes… More >

Sofija Jovanović Stojanov¹, Marija Grozdanić¹, Mila Ljujić², Sandra Dragičević², Miodrag Dragoj¹, Jelena Dinić^1,*

Oncology Research, Vol.33, No.10, pp. 2741-2785, 2025, DOI:10.32604/or.2025.067126 - 26 September 2025

Abstract Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies. Conventional two-dimensional (2D) cell cultures cannot replicate the complexity of the in vivo tumor microenvironment (TME), limiting their utility for drug resistance research. Therefore, three-dimensional (3D) tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms. In this review, various cancer 3D models, including spheroids, organoids, scaffold-based models, and bioprinted models, are comprehensively evaluated with a focus on their application in drug resistance studies. We discuss the materials, properties, and advantages of each model, highlighting More > Graphic Abstract

Xiaoqin Li, Yongfu Zhang^*, Zhen Ren, Jiao Chen, Zuqin Qiao, Xingmei Tao, Xuan Yi, Kai Wang, Zhao Liu

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2529-2550, 2025, DOI:10.32604/phyton.2025.066894 - 29 August 2025

Abstract Soil salinization is a major abiotic stress that hampers plant development and significantly reduces agricultural productivity, posing a serious challenge to global food security. Akebia trifoliata (Thunb.) Koidz, a species within the genus Akebia Decne., is valued for its use in food, traditional medicine, oil production, and as an ornamental plant. Curcumin, widely recognized for its pharmacological properties including anti-cancer, anti-neuroinflammatory, and anti-fibrotic effects, has recently drawn interest for its potential roles in plant stress responses. However, its impact on plant tolerance to saline-alkali stress remains poorly understood. In this study, the effects of curcumin on… More >

Xinxin Hu^1,2,#, Yuye Xue^3,#, Fei Fang⁴, Jie Li², Xiaofeng Yuan², Guang Cheng⁵, Hailong Yuan³, Yongqiang Zhang², Yuefei Zhou⁵, Shuangwu Yang⁵, Pengcheng Qiu^2,*, Yunyang Lu², Haifeng Tang^2,*

Oncology Research, Vol.33, No.9, pp. 2491-2506, 2025, DOI:10.32604/or.2025.064454 - 28 August 2025

Abstract Objectives: The Sorbin and SH3 domain containing 1 (SORBS1), a protein linked to insulin signaling CBL interaction, was investigated for its role in pancreatic cancer apoptosis. This study explored polyphyllin H (PPH)’s ability to restore SORBS1-knockdown-mediated repair functions. Methods: PANC-1 cells were divided into Blank, overexpression (OE), and knockdown groups. CCK-8 assays assessed proliferation and drug toxicity. Western blot and flow cytometry analyzed SORBS1 levels and PPH effects. Comet assays quantified DNA damage. Subcutaneous xenograft tumors in nude mice (Blank vs. knockdown) were treated with PPH to evaluate in vivo efficacy. SORBS1-H2AX gene correlation was analyzed… More > Graphic Abstract