WEI HU^1,#, THOMAS WARTMANN^2,#, MARCO STRECKER², ARISTOTELIS PERRAKIS², ROLAND CRONER², ARPAD SZALLASI³, WENJIE SHI^2,*, ULF D. KAHLERT^2,*

Oncology Research, Vol.32, No.1, pp. 227-239, 2024, DOI:10.32604/or.2023.043053

Abstract Transient receptor potential (TRP) channels are strongly associated with colon cancer development and progression. This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature, with further validation of signature in real world samples from our hospital treated patient samples. Kaplan-Meier (K-M) survival analysis and receiver operating characteristic (ROC) curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts, respectively. Additionally, the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.… More > Graphic Abstract

SAYAKA IMATSUJI^1,#, YUKIKO UJIE^1,#, HIROYUKI ODAKE¹, MASAYA IMOTO^1,2, SUSUMU ITOH³, ETSU TASHIRO^1,3,*

Oncology Research, Vol.32, No.1, pp. 139-150, 2024, DOI:10.32604/or.2023.030190

Abstract Growing evidence suggests an association between epithelial-mesenchymal transition (EMT), a hallmark of tumor malignancy, and chemoresistance to a number of anti-cancer drugs. However, the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains unclear. To address this issue, we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them lost cell-cell contacts. In these clones, the epithelial marker E-cadherin was downregulated, whereas the mesenchymal marker N-cadherin was upregulated. Moreover, the expression of EMT-related transcription factors, including Slug, was elevated. On the other hand, the upregulation of other mesenchymal marker Vimentin… More >

Wei Shi^1,2, Zhengyi Li¹, Xiaobing Xu¹, Yingshui Yu¹, Xiaofei Ding¹, Heng Ju^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.1, pp. 97-108, 2024, DOI:10.32604/fdmp.2023.029028

Abstract Two-dimensional carbon/carbon (2D C/C) composites are a special class of carbon/carbon composites, generally obtained by combining resin-impregnated carbon fiber clothes, which are then cured and carbonized. This study deals with the preparation of a protective coating for these materials. This coating, based on graphite, was prepared by the slurry method. The effect of graphite and phenolic resin powders with different weight ratios was examined. The results have shown that the coating slurry can fill the pores and cracks of the composite surface, thereby densifying the surface layer of the material. With the increase of the graphite powder/phenolic resin weight ratio,… More >

JIAZHUANG LI^*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860

Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

LIANLI NI^1,2,#, YUN YU^1,2,#, HAN LIN^1,2, WEISHAN ZHUGE², LU TAO², YIWEI SHEN², RI CUI^2,*, SHAOTANG LI^1,2,*

BIOCELL, Vol.47, No.10, pp. 2245-2254, 2023, DOI:10.32604/biocell.2023.030147

Abstract Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC… More >

Dengyun Li, Baiwen Du, Kai Zhu, Jicheng Yu^*, Siyuan Liang, Changxi Yue

Energy Engineering, Vol.120, No.11, pp. 2611-2628, 2023, DOI:10.32604/ee.2023.028282

Abstract Self-heating and electric field distribution are the primary factors affecting the accuracy of the Ultra High Voltage Direct Current (UHVDC) resistive divider. Reducing the internal temperature rise of the voltage divider caused by self-heating, reducing the maximum electric field strength of the voltage divider, and uniform electric field distribution can effectively improve the UHVDC resistive divider’s accuracy. In this paper, thermal analysis and electric field distribution optimization design of 1200 kV UHVDC resistive divider are carried out: (1) Using the proposed iterative algorithm, the heat dissipation and temperature distribution of the high voltage DC resistive divider are studied, and the… More >

Lanjun Li¹, Degang Zhao^1,2,*

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3043-3061, 2023, DOI:10.32604/phyton.2023.031175

Abstract Various strains of powdery mildew (PM), a notorious plant fungal disease, are prevalent and pose a significant threat to plant health. To control PM, transgenic technology can be used to cultivate more resistant plant varieties. In the present study, we utilized the rapid amplification of cDNA ends (RACE) technique to clone the full-length cDNA sequence of the EuCHIT30.7 gene to explore plant genes with disease resistance functions. Bioinformatics analysis revealed that this gene belongs to the GH18 family and is classified as a class III chitinase. The EuCHIT30.7 gene is expressed throughout the Eucommia ulmoides plant, with the most abundant… More >

POOJA BHADORIYA¹, RICHA SHARMA¹, REKHA MEHROTRA¹, SIMRAN KAUR¹, ISHA SRIVASTAVA¹, MUKUL JAIN², PRASHANT KAUSHIK^3,*

BIOCELL, Vol.47, No.9, pp. 1915-1930, 2023, DOI:10.32604/biocell.2023.029564

Abstract In the present medicine world antibiotic resistance is one of the key threats to universal health coverage. Researchers continue to work hard to combat this global health concern. Phage therapy, an age-old practice during the early twentieth century, was outshined by the discovery of antibiotics. With the advent of widespread antibiotic resistance, phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely. Limited side effects, the ability to migrate to different body organs, a distinct mode of action, and proliferation at the infection site, make phages a profitable candidate to replace conventional… More > Graphic Abstract

RUI ZHANG^1,2,#, PENG ZHOU^1,3,#, XIA OU⁴, PEIZHU ZHAO², XIJING GUO², MIAN XI^5,*, CHEN QING^1,*

Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184

Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in ESCC. Additionally, suppression of DMRTA1… More >

MUNEEBA MALIK¹, MAMOONA MAQBOOL², TOOBA NISAR³, TAZEEM AKHTER⁴, JAVED AHMED UJAN^5,6, ALANOOD S. ALGARNI⁷, FAKHRIA A. AL JOUFI⁸, SULTAN SHAFI K. ALANAZI⁹, MOHAMMAD HADI ALMOTARED¹⁰, MOUNIR M. SALEM BEKHIT¹¹, MUHAMMAD JAMIL^12,*

Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760

Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information (NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes retrieved were analyzed… More >