LI TIAN^1,#, YONGYI HUANG^1,#, BAOZHEN ZHANG^2,#, YI SONG^1,#, LIN YANG³, QIANQIAN CHEN¹, ZHENG WANG³, YILING WANG¹, QIHAN HE¹, WENHAN YANG¹, SHUYONG YU⁴, TIANYU LU⁵, ZICHEN LIU¹, KAIPING GAO^1,*, XIUJUN FAN^2,*, JIAN SONG^4,*, RIHONG ZHAI^1,*

Oncology Research, Vol.31, No.4, pp. 463-479, 2023, DOI:10.32604/or.2023.028791

Abstract Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in the development and progression of cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge. By RNA-sequencing analysis, we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA. LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion. Silencing of LLNLR-299G3.1 with ASO (antisense oligonucleotide) resulted in opposite effects. Mechanistically, LLNLR-299G3.1 bound to cancer-associated RNA binding proteins and regulated the expression of cancer-related… More >

Muhammad Aamir¹, Ziaur Rahman^1,*, Waheed Ahmed Abro², Uzair Aslam Bhatti³, Zaheer Ahmed Dayo¹, Muhammad Ishfaq¹

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6351-6373, 2023, DOI:10.32604/cmc.2023.038173

Abstract Object detection in images has been identified as a critical area of research in computer vision image processing. Research has developed several novel methods for determining an object’s location and category from an image. However, there is still room for improvement in terms of detection efficiency. This study aims to develop a technique for detecting objects in images. To enhance overall detection performance, we considered object detection a two-fold problem, including localization and classification. The proposed method generates class-independent, high-quality, and precise proposals using an agglomerative clustering technique. We then combine these proposals with the relevant input image to train… More >

Xianrong Fu, Aiping Song, Bo Peng, Song Li, Weixin Liu, Lingling Zhang, Jiafu Jiang, Sumei Chen, Fadi Chen^*

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1681-1694, 2023, DOI:10.32604/phyton.2023.027870

Abstract Brassinosteroids (BRs), a class of steroid phytohormones, play a critical role in plant growth and development. The DWF4 gene encodes a cytochrome P450 enzyme (CYP90B1), which is considered a rate-limiting enzyme in BR biosynthesis. Here, we identified a homologous gene of DWF4 in chrysanthemum, CmDWF4. This gene was predicted to encode 491 amino acid residues with a molecular weight of 56.2 kDa and an isoelectric point (pI) of 9.10. Overexpression of CmDWF4 in chrysanthemum was found to significantly increase growth rate, number, and length of lateral buds. Transcriptome analysis showed that multiple xyloglucan endotransglycosylase/hydrolase (XTH) family encoding genes associated with… More >

Thien-Phuc Doan, Ngoc-Tu Chau, Jungsoo Park, Souhwan Jung^*

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3059-3073, 2023, DOI:10.32604/csse.2023.038664

Abstract Nowadays, with the significant growth of the mobile market, security issues on the Android Operation System have also become an urgent matter. Trusted execution environment (TEE) technologies are considered an option for satisfying the inviolable property by taking advantage of hardware security. However, for Android, TEE technologies still contain restrictions and limitations. The first issue is that non-original equipment manufacturer developers have limited access to the functionality of hardware-based TEE. Another issue of hardware-based TEE is the cross-platform problem. Since every mobile device supports different TEE vendors, it becomes an obstacle for developers to migrate their trusted applications to other… More >

Ramzy S. Hamied¹, Zaidoon M. Shakor^2,*, Anfal H. Sadeiq¹, Adnan A. Abdul Razak², Ammar T. Khadim³

Energy Engineering, Vol.120, No.6, pp. 1371-1386, 2023, DOI:10.32604/ee.2023.028441

Abstract Recently, the isomerization of light naphtha has been increasingly significant in assisting refiners in meeting sternness specifications for gasoline. Isomerization process provides refiners with the advantage of reducing sulfur, olefin, and benzene in the gasoline basin without significantly victimizing the octane. The mathematical modeling of a chemical reaction is a critical tool due to it can used to optimize the experimental data to estimate the optimum operating conditions for industrial reactors. This paper describes light naphtha isomerization reactions over a Pt/Al₂O₃-Cl catalyst at the Al-Dura Oil Refinery (Baghdad, Iraq) using a newly developed universal mathematical model. The proposed kinetic model… More >

SANDRA STICKLER¹, BARBARA RATH¹, MAXIMILIAN HOCHMAIR², CLEMENS LANG³, LUKAS WEIGL⁴, GERHARD HAMILTON^1,*

Oncology Research, Vol.31, No.1, pp. 13-22, 2023, DOI:10.32604/or.2022.027281

Abstract Small cell lung cancer (SCLC) is frequently disseminated and has a dismal prognosis with survival times of approximately two years. This cancer responds well to initial chemotherapy but recurs within a short time as a globally chemoresistant tumor. Circulating tumor cells (CTCs) are held responsible for metastasis, the extremely high numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell lines. These CTCs are distinguished by the spontaneous formation of large spheroids, termed tumorospheres, in regular tissue culture. These contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to… More >

Younghoon Ban, Jeong Hyun Yi, Haehyun Cho^*

Computer Systems Science and Engineering, Vol.46, No.2, pp. 2215-2230, 2023, DOI:10.32604/csse.2023.036555

Abstract Android malware has evolved in various forms such as adware that continuously exposes advertisements, banking malware designed to access users’ online banking accounts, and Short Message Service (SMS) malware that uses a Command & Control (C&C) server to send malicious SMS, intercept SMS, and steal data. By using many malicious strategies, the number of malware is steadily increasing. Increasing Android malware threats numerous users, and thus, it is necessary to detect malware quickly and accurately. Each malware has distinguishable characteristics based on its actions. Therefore, security researchers have tried to categorize malware based on their behaviors by conducting the familial… More >

Mousa Alhajlah¹, Muhammad Nouman Noor², Muhammad Nazir², Awais Mahmood^1,*, Imran Ashraf³, Tehmina Karamat⁴

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 2227-2245, 2023, DOI:10.32604/cmc.2023.031890

Abstract Gastrointestinal diseases like ulcers, polyps’, and bleeding are increasing rapidly in the world over the last decade. On average 0.7 million cases are reported worldwide every year. The main cause of gastrointestinal diseases is a Helicobacter Pylori (H. Pylori) bacterium that presents in more than 50% of people around the globe. Many researchers have proposed different methods for gastrointestinal disease using computer vision techniques. Few of them focused on the detection process and the rest of them performed classification. The major challenges that they faced are the similarity of infected and healthy regions that misleads the correct classification accuracy. In… More >

A. Thiruppathi^*, C. K. Kirubhashankar

Intelligent Automation & Soft Computing, Vol.36, No.2, pp. 2253-2266, 2023, DOI:10.32604/iasc.2023.033870

Abstract The output of the fuzzy set is reduced by one for the defuzzification procedure. It is employed to provide a comprehensible outcome from a fuzzy inference process. This page provides further information about the defuzzification approach for quadrilateral fuzzy numbers, which may be used to convert them into discrete values. Defuzzification demonstrates how useful fuzzy ranking systems can be. Our major purpose is to develop a new ranking method for generalized quadrilateral fuzzy numbers. The primary objective of the research is to provide a novel approach to the accurate evaluation of various kinds of fuzzy integers. Fuzzy ranking properties are… More >

Roberta Costanzo¹, Vishal Parmar², Salvatore Marrone¹, Domenico Gerardo Iacopino¹, Giovanni Federico Nicoletti³, Giuseppe Emmanuele Umana⁴, Gianluca Scalia^3,*

Oncologie, Vol.24, No.4, pp. 937-942, 2022, DOI:10.32604/oncologie.2022.027155

Abstract Primary intracranial melanomas are rare, with a challenging diagnosis based only on clinical and imaging features. The authors described the case of an intracerebral right parieto-temporal melanoma mimicking a cavernoma in a patient affected by Crohn’s disease. A 67-year-old female patient with Crohn’s disease and small bowel stenosis was hospitalized for surgical removal of the terminal ileum and latero-lateral ileo-colic anastomosis. During postoperative week 1, the patient developed psychomotor agitation followed by altered consciousness. An urgent brain CT showed a right intracerebral parieto-temporal hemorrhage with intralesional calcifications. The patient underwent a decompressive craniectomy with hematoma drainage and a complete resection… More >