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  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

  • Open Access

    ARTICLE

    Preparation and Characterization of Biobased Dehydroabietyl Polyethylene Glycol Glycidyl Ether-Grafted Hydroxyethyl Cellulose with High Emulsifying Property

    Zhengqing Ding, Quan Yang, Xinyan Yan, Feng Gu, Xujuan Huang*, Zhaosheng Cai*

    Journal of Renewable Materials, Vol.12, No.1, pp. 103-117, 2024, DOI:10.32604/jrm.2023.029424

    Abstract Dehydroabietyl polyethylene glycol glycidyl ether-grafted hydroxyethyl cellulose (HEC) polymer surfactant (DA(EO)5GE-g-HEC) was prepared using ring-opening polymerization with biobased rosin and hydroxyethyl cellulose as feedstocks. Dehydroabietyl polyethylene glycol glycidyl ether (DA(EO)5GE) was formed by condensation of dehydroabietyl alcohol polyoxyethylene ether (Rosin derivative: DA(EO)5H) and epichlorohydrin. The grafting degree of DA(EO)5GE-g-HEC was manipulated by adjusting the mass ratio of HEC and DA(EO)5GE and confirmed by EA. According to the formula, when m(HEC)/m(DA(EO)2GE) was 1:1~1:5, the grafting rate of DA(EO)5GE in DA(EO)5GE-g-HEC varied from 34.43% to 38.33%. The surface activity and foam properties of DA(EO)5GE-g-HEC aqueous solution were studied. The results showed that… More > Graphic Abstract

    Preparation and Characterization of Biobased Dehydroabietyl Polyethylene Glycol Glycidyl Ether-Grafted Hydroxyethyl Cellulose with High Emulsifying Property

  • Open Access

    ARTICLE

    Maternal Vascular Dysfunction in Congenital Heart Defects

    Yanli Liu1,2, Fengzhen Han2, Jian Zhuang4, Yanqiu Ou4, Yanji Qu5, Yanyan Lin2, Weina Zhang2, Haiping Wang3,*, Liping Huang1,*

    Congenital Heart Disease, Vol.18, No.5, pp. 561-570, 2023, DOI:10.32604/chd.2023.030511

    Abstract Background: Research on fetal congenital heart defect (CHD) mostly focuses on etiology and mechanisms. However, studies on maternal complications or pathophysiology are limited. Our objective was to determine whether vascular dysfunction exists in pregnant women carrying a fetus with congenital heart defects. Methods: We conducted a case-control study. 27 cases of pregnant women carrying a fetus with major CHD admitted to our hospital for delivery between April 2021 and August 2022 were selected. Every case was matched with about 2 pregnant complication-free controls without fetal abnormalities. The proangiogenic and anti-angiogenic factors and pregnancy outcomes were compared. Results: The proangiogenic factors… More > Graphic Abstract

    Maternal Vascular Dysfunction in Congenital Heart Defects

  • Open Access

    ARTICLE

    Effects of Tsukamurella tyrosinosolvens P9 on growth, physiology and antioxdant enzyme of peanut under drought stress and after re-watering

    CHANGMEI LONG, TINGTING YANG, YUJIE HAN, LIZHEN HAN*

    BIOCELL, Vol.47, No.6, pp. 1417-1430, 2023, DOI:10.32604/biocell.2023.027485

    Abstract Background: The plant-growth-promoting rhizobacterium Tsukamurella tyrosinosolvens is a rare strain of actinomycete, in order to recognize and expand the ecological functions of rare actinomycetes. Methods: In this experiment, we studied the effect of Tsukamurella tyrosinosolvens P9 on the drought resistance of peanut by inoculating peanut seedlings in pots and measuring the growth and physiological indicators of peanut under drought stress and re-watering conditions. Results: The results showed that during drought stress, the relative water content of the soil and leaves, chlorophyll content, and stomatal length, width, and aperture were significantly decreased while the levels of malondialdehyde (MDA), H2O2 and stomatal… More >

  • Open Access

    ARTICLE

    Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway

    SHU ZHAO1,*, SHIXIN YE2

    BIOCELL, Vol.47, No.6, pp. 1377-1388, 2023, DOI:10.32604/biocell.2023.023874

    Abstract Background: This paper aims to establish a light-controlled phosphorylation detection method at the Y785 site of tropomyosin receptor kinase A (TrkA) receptor in mammalian cells by using genetic code expansion technology and detecting the effects of optical activation of this site on the downstream MAPK/ERK pathway. The study is based on the current situation that the regulatory mechanism of TrkA phosphorylation has not been fully elucidated. Methods: Two photosensitive unnatural amino acids, p-azido-L-phenylalanine (AzF) and photo-caged tyrosine (ONB) were introduced into the TrkA-Y785 site by genetic code expansion technology and site-directed mutagenesis. Western blotting and laser confocal imaging were conducted… More >

  • Open Access

    ARTICLE

    Synthesis and Properties of Rosin-Based Composite Acrylamide Hydrogels

    Shuangsheng Zhang, Bin Sun, Siyu Li, Xiangyu Lin, Muhua Chen*, Xu Xu*

    Journal of Renewable Materials, Vol.11, No.2, pp. 853-865, 2023, DOI:10.32604/jrm.2022.022901

    Abstract Hydrogels have been widely applied in agricultural drought-resistance, pollution regulation, drug delivery and so on. Acrylamide (AM) is usually used as raw material to synthesize acrylamide hydrogels. However, inherently low mechanical strength greatly limits their applications in some special areas. Therefore, it is necessary to choose suitable functional monomers to optimize acrylamide hydrogels and improve their mechanical performances. In this paper, a novel acrylamide monomer modified by rosin was synthesized, and then polyacrylamide/rosin-based acrylamide (RAM) composite hydrogels were prepared via free radical polymerization using potassium persulfate as initiator, N, N′-methylene-bisacrylamide (MBA) as a crosslinker. The influence of RAM monomer was… More > Graphic Abstract

    Synthesis and Properties of Rosin-Based Composite Acrylamide Hydrogels

  • Open Access

    ARTICLE

    CO2-Responsive Smart Foams Stabilized by an Extremely Rigid Bio-Based Surfactant

    Weishan Tang, Xin Feng, Caiyun Lin, Xiaoping Rao*

    Journal of Renewable Materials, Vol.11, No.2, pp. 523-538, 2023, DOI:10.32604/jrm.2022.022809

    Abstract Environment friendly and intelligent surfactants have attracted great attention in recent years. A bio-based CO2 responsive surfactant rosin acid dimaleimide choline (R-BMI-C) with an extremely rigid skeleton was prepared using rosin and choline as raw materials by Diels-Alder addition reaction and acid-base neutralization reactions. Its structure was confirmed by IR and 1H NMR spectra. The foams’ properties of R-BMI-C could be adjusted by bubbling CO2/N2 to change the structure of the surfactant. At pH 10.4, R-BMI-C forms an unstable foam with a half-life of 1.5 h. When the pH was reduced to 7.4 by bubbling CO2, R-BMI-C forms an extremely… More > Graphic Abstract

    CO<sub>2</sub>-Responsive Smart Foams Stabilized by an Extremely Rigid Bio-Based Surfactant

  • Open Access

    ARTICLE

    Evaluation of Weathering Performance of Rosin-Copper Based Treated Wood

    Thi Thanh Hien Nguyen1,*, Nho Quyet Tran2, Thi Minh Nguyet Nguyen1, Hien Mai Trinh1, Xuan Phuong Le1, Trong Kien Nguyen1

    Journal of Renewable Materials, Vol.10, No.11, pp. 2765-2780, 2022, DOI:10.32604/jrm.2022.019634

    Abstract This study aimed to evaluate the effect of natural weathering on some surface characteristics and mechanical properties of Styrax wood treated with mixtures of 1.0%, 2.0%, or 4.0% rosin sizing agent and 3% copper sulfate. Wood samples after treatment were exposed to outdoor conditions for one year and changes in color, glossiness, weight loss, compression strength parallel to grain (CSPG), modulus of rupture (MOR), and modulus of elasticity (MOE) were investigated after 6 and 12-month of natural weathering. The results showed that rosin-copper treatment could improve color stability and gloss of samples after weathering. Mass losses of all rosin-copper treated… More > Graphic Abstract

    Evaluation of Weathering Performance of Rosin-Copper Based Treated Wood

  • Open Access

    ARTICLE

    Secreted Phosphoprotein 1 (SPP1) Contributes to Second-Generation EGFR Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer

    Xinwen Wang, Fupeng Zhang, Xi Yang, Meiping Xue, Xiaoli Li, Yu Gao, Likun Liu

    Oncology Research, Vol.27, No.8, pp. 871-877, 2019, DOI:10.3727/096504018X15426271404407

    Abstract Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), afatinib, has been approved for treating EGFR mutant lung cancer patients, but the mechanism of acquired resistance to afatinib has not been well studied. In this study, we established afatinib acquired resistant cell lines. Gene array technology was used to screen changes in gene expression between afatinib-resistant lung cancer cells and parental cells. Our results showed that secreted phosphoprotein 1 (SPP1) was significantly increased in afatinib-resistant lung cancer cells. To study the effect of SPP1 on afatinib resistance, siSPP1 was used to knock down SSP1 in afatinib-resistant lung cancer… More >

  • Open Access

    ARTICLE

    TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis

    Gaowu Hu, Wei Pen, Ming Wang

    Oncology Research, Vol.27, No.4, pp. 439-447, 2019, DOI:10.3727/096504018X15214994641786

    Abstract Tripartite motif-containing 14 (TRIM14) is abnormally expressed in several human cancers. However, the function and expression of TRIM14 in human breast cancer are still largely unknown. To understand the biological function of TRIM14 in breast cancer, we measured the expression level of TRIM14. Cell proliferation and cell apoptosis were measured after TRIM14 overexpression or knockdown. Upregulation of TRIM14 was found in human breast cancer specimens and cell lines. Reduction of TRIM14 inhibited cell proliferation but increased cell apoptosis in the BT474 and MDA-MB-231 cell lines. Further study showed that knockdown of TRIM14 upregulated the expression of BAX while downregulating the… More >

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