Open Access
ARTICLE
Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells
Jianping Zhou*, Fan Wang†, Bingli Liu‡, Lin Yang*, Xueying Wang*, Yu Liu*
* Department of Pediatrics, The Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an, P.R. China
† Department of Obstetrics and Gynecology, Shaanxi Provincial People’s Hospital, Xi’an, P.R. China
‡ Department of General Surgery, The Second Affiliated Hospital, Medical College of Xi’an Jiaotong University,
Xi’an, P.R. China
Oncology Research 2017, 25(6), 931-937. https://doi.org/10.3727/096504016X14772424117423
Abstract
Pediatric glioma is a devastating brain tumor. Serine threonine tyrosine kinase 1 (STYK1) is a member of
the protein tyrosine kinase family and plays a significant role in the formation of several malignant tumors.
However, the expression pattern and role of STYK1 in glioma are not yet clear. The aim of this study was to
investigate the role and molecular mechanism of STYK1 in glioma. The results showed that STYK1 was highly
expressed in glioma cell lines. We also found that knockdown of STYK1 inhibited cell proliferation, migration, and invasion in vitro as well as tumorigenesis in vivo. Furthermore, knockdown of STYK1 significantly
decreased the expression levels of phosphorylation of PI3K and Akt in glioma cells. Taken together, our data
suggest that STYK1 plays an important role in the development and progression of glioma. Therefore, STYK1
may represent a novel therapeutic target for the treatment of glioma.
Keywords
Cite This Article
APA Style
Zhou, J., Wang, F., Liu, B., Yang, L., Wang, X. et al. (2017). Knockdown of serine threonine tyrosine kinase 1 (STYK1) inhibits the migration and tumorigenesis in glioma cells. Oncology Research, 25(6), 931-937. https://doi.org/10.3727/096504016X14772424117423
Vancouver Style
Zhou J, Wang F, Liu B, Yang L, Wang X, Liu Y. Knockdown of serine threonine tyrosine kinase 1 (STYK1) inhibits the migration and tumorigenesis in glioma cells. Oncol Res. 2017;25(6):931-937 https://doi.org/10.3727/096504016X14772424117423
IEEE Style
J. Zhou, F. Wang, B. Liu, L. Yang, X. Wang, and Y. Liu "Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells," Oncol. Res., vol. 25, no. 6, pp. 931-937. 2017. https://doi.org/10.3727/096504016X14772424117423