Douglas M. Ruden^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072273 - 23 January 2026

Abstract Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs: the integrated stress response (ISR) and the senescence-associated secretory phenotype (SASP). These pathways act as a Yin–Yang system, balancing beneficial and detrimental outcomes across development, tissue homeostasis, and disease. On the yin (protective) side, transient ISR activation and acute SASP signaling foster adaptation, embryonic patterning, wound healing, and regeneration. On the yang (maladaptive) side, chronic ISR signaling and unresolved SASP output drive stem cell exhaustion, fibrosis, inflammation, and tumorigenesis. This duality highlights their roles as both guardians and disruptors More > Graphic Abstract

JIANBO ZHOU^1,2,3, FENG WAN^2,4, BIN XIAO⁵, XIN LI¹, CHENG PENG^2,*, FU PENG^1,3,*

Oncology Research, Vol.32, No.5, pp. 943-953, 2024, DOI:10.32604/or.2023.044775 - 23 April 2024

Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC More > Graphic Abstract

Shichao Cao^*, Yonggang Dong, Xiaoying Liu

Energy Engineering, Vol.121, No.4, pp. 1109-1125, 2024, DOI:10.32604/ee.2023.043004 - 26 March 2024

Abstract The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine. It also has the same inertia, damping, frequency, voltage regulation, and other external performance as the generator. It is the key technology to realize new energy grid connections’ stable and reliable operation. This project studies a dynamic simulation model of an extensive new energy power system based on the virtual synchronous motor. A new energy storage method is proposed. The mathematical energy storage model is established by combining the fixed rotor model of a synchronous virtual machine with the… More >