Shanshan Wang^1,2,3, Quan Yuan¹, Weiwei Tan¹, Tengfei Yang¹, Liang Zeng^1,2,3,*

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3057-3075, 2023, DOI:10.32604/cmc.2023.044807

Abstract Feature Selection (FS) is an important problem that involves selecting the most informative subset of features from a dataset to improve classification accuracy. However, due to the high dimensionality and complexity of the dataset, most optimization algorithms for feature selection suffer from a balance issue during the search process. Therefore, the present paper proposes a hybrid Sine-Cosine Chimp Optimization Algorithm (SCChOA) to address the feature selection problem. In this approach, firstly, a multi-cycle iterative strategy is designed to better combine the Sine-Cosine Algorithm (SCA) and the Chimp Optimization Algorithm (ChOA), enabling a more effective search in the objective space. Secondly,… More >

MENGYING MAO^1,2,3,#, TING DONG^1,2,3,#, YANJING LIANG^3,4, KEYONG YUAN^1,2,3, QIAOQIAO JIN^1,2,3, PENGFEI ZHANG^1,2,3, ZHENGWEI HUANG^1,2,3,*

BIOCELL, Vol.47, No.10, pp. 2187-2193, 2023, DOI:10.32604/biocell.2023.042357

Abstract The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and is highly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balance existing between the oral microbiota and host may be disturbed and result in the development of diseases. Numerous observations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions. Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacious therapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria… More > Graphic Abstract

FENGXIANG TANG, YANSHI LI, MIN PAN, ZHIHAI WANG, TAO LU, CHUAN LIU, XIN ZHOU, GUOHUA HU^*

Oncology Research, Vol.31, No.5, pp. 787-803, 2023, DOI:10.32604/or.2023.030081

Abstract Background: Lymphatic metastasis (LM) emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma (HSPSCC), chiefly contributing to treatment inefficacy. This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC. Methods: In a preceding investigation, HSP90AA1, a differential gene, was discovered through transcriptome sequencing of HPSCC tissues, considering both the presence and absence of LM. Validation of HSP90AA1 expression was accomplished via qRT-PCR, western-blotting(WB), and immunohistochemistry(IHC), while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA), log-rank test(LR), and Cox’s regression analysis(CRA). Bioinformatics techniques facilitated the prediction and analysis… More > Graphic Abstract

FAYU SHAN¹, LANLAN LIANG¹, CHONG FENG¹, HONGBAO XU¹, ZIROU WANG¹, WEILI LIU¹, LINGLING PU¹, ZHAOLI CHEN¹, GANG CHEN^2,*, XINXING WANG^1,*

Oncology Research, Vol.31, No.4, pp. 481-493, 2023, DOI:10.32604/or.2023.029064

Abstract Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently, Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; however, how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored. This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC. Methods: To explore the mechanism by which LAMC2 is highly expressed in OSCC, we used small interfering RNA (siRNA) to knock down LAMC2 to further observe the changes in the… More >

LI TIAN^1,#, YONGYI HUANG^1,#, BAOZHEN ZHANG^2,#, YI SONG^1,#, LIN YANG³, QIANQIAN CHEN¹, ZHENG WANG³, YILING WANG¹, QIHAN HE¹, WENHAN YANG¹, SHUYONG YU⁴, TIANYU LU⁵, ZICHEN LIU¹, KAIPING GAO^1,*, XIUJUN FAN^2,*, JIAN SONG^4,*, RIHONG ZHAI^1,*

Oncology Research, Vol.31, No.4, pp. 463-479, 2023, DOI:10.32604/or.2023.028791

Abstract Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in the development and progression of cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge. By RNA-sequencing analysis, we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA. LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion. Silencing of LLNLR-299G3.1 with ASO (antisense oligonucleotide) resulted in opposite effects. Mechanistically, LLNLR-299G3.1 bound to cancer-associated RNA binding proteins and regulated the expression of cancer-related… More >

ZHIXUN XIAO¹, QIUYUN XU¹, HAIQING WANG¹, XIAOTONG ZHOU², YANTING ZHU¹, CHENGBEI BAO¹, LIHONG CHEN¹, PENG ZHANG¹, MIN LIN¹, CHAO JI^1,*, TING GONG^3,*

Oncology Research, Vol.31, No.1, pp. 71-82, 2023, DOI:10.32604/or.2022.028075

Abstract Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the TXN family that is important in cell differentiation. However, the biological function of this protein in cancer, particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9 on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of TXNDC9, and UV-B-induced cSCC cell… More >

QING GAO^1,#, YUJING SHI^2,#, YUANYUAN SUN^1,#, SHU ZHOU¹, ZEYUAN LIU³, XINCHEN SUN^1,*, XIAOKE DI^1,*

Oncology Research, Vol.31, No.1, pp. 35-61, 2023, DOI:10.32604/or.2022.028193

Abstract Aging is highly associated with tumor formation and progression. However, little research has explored the association of aging-related lncRNAs (ARLs) with the prognosis and tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma (HNSCC). RNA sequences and clinicopathological data of HNSCC patients and normal subjects were downloaded from The Cancer Genome Atlas. In the training group, we used Pearson correlation, univariate Cox regression, least absolute shrinkage/selection operator regression analyses, and multivariate Cox regression to build a prognostic model. In the test group, we evaluated the model. Multivariate Cox regression was done to screen out independent prognostic factors, with… More >

USAMA SHARIF AHMAD, KARTHIK SARAVANAN, HONG WAN^*

Oncology Research, Vol.29, No.6, pp. 377-391, 2021, DOI:10.32604/or.2022.026085

Abstract The Yes-associated protein (YAP) is a downstream effector of the Hippo pathway and acts as a key transcription co-factor to regulate cell migration, proliferation, and survival. The Hippo pathway is evolutionarily conserved and controls tissue growth and organ size. Dysregulation and heterogeneity of this pathway are found in cancers, including oral squamous cell carcinoma (OSCC), leading to overexpression of YAP and its regulated proliferation machinery. The activity of YAP is associated with its nuclear expression and is negatively regulated by the Hippo kinase-mediated phosphorylation resulting in an induction of its cytoplasmic translocation. This review focuses on the role of YAP… More >

JINXIAN LIU¹, JINGFANG FENG², CHANG ZHANG², YONGJUAN REN², WEIHUA SU², GUANGHENG WU¹, XIANYU FU¹, NING HUANG³, YOUXIONG QUE², HUI LING^3,*, JUN LUO^2,*

BIOCELL, Vol.47, No.1, pp. 215-225, 2023, DOI:10.32604/biocell.2022.022477

Abstract Calmodulin (CaM) proteins play a key role in signal transduction under various stresses. In the present study, the effects of a sugarcane ScCaM gene (NCBI accession number: GQ246454) on drought and salt stress tolerance in transgenic Arabidopsis thaliana and Escherichia coli cells were evaluated. The results demonstrated a significant negative role of ScCaM in the drought and salt stress tolerance of transgenic lines of A. thaliana, as indicated by the phenotypes. In addition, the expression of AtP5CS and AtRD29A, two genes tightly related to stress resistance, was significantly lower in the overexpression lines than in the wild type. The growth… More >

Khadem Ullah^1,*, Nasru Minallah¹, Durre Nayab¹, Ishtiaque Ahmed², Jaroslav Frnda^3,4, Jan Nedoma⁴

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 995-1010, 2023, DOI:10.32604/cmc.2023.030531

Abstract With the ever growth of Internet users, video applications, and massive data traffic across the network, there is a higher need for reliable bandwidth-efficient multimedia communication. Versatile Video Coding (VVC/H.266) is finalized in September 2020 providing significantly greater compression efficiency compared to Highest Efficient Video Coding (HEVC) while providing versatile effective use for Ultra-High Definition (HD) videos. This article analyzes the quality performance of convolutional codes, turbo codes and self-concatenated convolutional (SCC) codes based on performance metrics for reliable future video communication. The advent of turbo codes was a significant achievement ever in the era of wireless communication approaching nearly… More >