XUELIANG WU1,#, SHAOYU GUAN2,#, YONGGANG LU3, JUN XUE4, XIANGYANG YU1, QI ZHANG5,*, XIMO WANG1,5,*, TIAN LI6
Oncology Research, Vol.31, No.2, pp. 125-139, 2023, DOI:10.32604/or.2023.028657
Abstract This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase (SHP-
2) on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2 (Tie2)-expressing
monocyte/macrophages (TEMs) and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase
(PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) (Ang/Tie2-PI3K/Akt/mTOR) signaling
pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment. In vivo, SHP-2-
deficient mice were used to construct colorectal cancer (CRC) liver metastasis models. SHP-2-deficient mice had
significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice, and the high-level
expression of p-Tie2 was found in… More >
Graphic Abstract
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