Xuejun Guo^1,2, Yilin Fu³, Natalia Baran^4,5, Wenxue Ma^6,*

Oncology Research, Vol.33, No.11, pp. 3375-3385, 2025, DOI:10.32604/or.2025.071708 - 22 October 2025

Abstract Cluster of differentiation 47 (CD47), an immune checkpoint commonly referred to as the “don’t eat me” signal, plays a pivotal role in tumor immune evasion by inhibiting phagocytosis through interaction with signal regulatory protein alpha (SIRPα) on macrophages and dendritic cells (DCs). Although early enthusiasm drove broad clinical development, recent discontinuations of major CD47-targeted programs have prompted re-evaluation of its therapeutic potential. The purpose of this commentary is to contextualize the setbacks observed with first-generation CD47 inhibitors and to highlight strategies aimed at overcoming their limitations. Clinical challenges, including anemia, thrombocytopenia, suboptimal pharmacokinetics, and limited… More >

Sumeyra Ucar¹, Muhammed Aldaif ², Esra Yaprak¹, Esma Yigider ², Murat Aydin^2,*, Emre Ilhan¹, Abdulkadir Ciltas², Ertan Yildirim³

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2461-2477, 2025, DOI:10.32604/phyton.2025.068383 - 29 August 2025

Abstract Wheat is a crucial crop for global food security, and effective in vitro plant regeneration techniques are considered a precondition for genetic engineering in wheat breeding programs. A practical approach for in vitro regeneration of the Kırik bread wheat cultivar via somatic embryogenesis was investigated using endosperm-supported mature embryos. Callus cultures were initiated from mature embryos supported by endosperm, cultured on phytagel-based Murashige and Skoog (MS) basal medium containing dicamba (12 mg/L) and indole-3-acetic acid (IAA) (0.5 mg/L) under dark conditions. This research was designed to examine the impact of putrescine (Put) (0.0 and 1.0 mM) on… More >

Chuanchuan Wang^1,2, Ahmad Sufril Azlan Mohamed^2,*, Xiao Yang ², Hao Zhang ², Xiang Li¹, Mohd Halim Bin Mohd Noor ²

CMC-Computers, Materials & Continua, Vol.85, No.1, pp. 855-874, 2025, DOI:10.32604/cmc.2025.066343 - 29 August 2025

Abstract Classroom behavior recognition is a hot research topic, which plays a vital role in assessing and improving the quality of classroom teaching. However, existing classroom behavior recognition methods have challenges for high recognition accuracy with datasets with problems such as scenes with blurred pictures, and inconsistent objects. To address this challenge, we proposed an effective, lightweight object detector method called the RFNet model (YOLO-FR). The YOLO-FR is a lightweight and effective model. Specifically, for efficient multi-scale feature extraction, effective feature pyramid shared convolutional (FPSC) was designed to improve the feature extract performance by leveraging convolutional… More >

Shaodong Zou¹, Di Wu¹, Jianhou Gan^1,2,*, Juxiang Zhou^1,2, Jiatian Mei^1,2

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1101-1116, 2025, DOI:10.32604/cmc.2025.061376 - 26 March 2025

Abstract The task of student action recognition in the classroom is to precisely capture and analyze the actions of students in classroom videos, providing a foundation for realizing intelligent and accurate teaching. However, the complex nature of the classroom environment has added challenges and difficulties in the process of student action recognition. In this research article, with regard to the circumstances where students are prone to be occluded and classroom computing resources are restricted in real classroom scenarios, a lightweight multi-modal fusion action recognition approach is put forward. This proposed method is capable of enhancing the… More >

TINGTING LIU^#, XIANGRUI KONG^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.12, pp. 1735-1749, 2024, DOI:10.32604/biocell.2024.056272 - 30 December 2024

Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. In recent times, an elevated risk of Parkinson’s disease (PD) development among individuals with T2DM has become evident. However, the molecular mechanisms that underpin the interplay between T2DM and the pathogenesis of PD remain to be elucidated. Nevertheless, recent epidemiological studies have underscored several shared molecular pathways that are crucial for normal cellular function and are also associated with the progression and etiology of both T2DM and PD. This review encapsulates some of the shared pathophysiological mechanisms, including genetic risk factors, More >

Md. Mosiur Rahman^1,2, Md. Ruhul Quddus³, Quanle Xu⁴, Muhammad Malek Hossain², Rong Liu¹, Mengwei Li¹, Xin Yan¹, Guan Li¹, Yishan Ji¹, Chenyu Wang¹, Ashutosh Sarker⁵, Tao Yang¹, Xuxiao Zong¹, Md. Monoar Hossain⁶, Saleh Alfarraj⁷, Mohammad Javed Ansari⁸, Sagar Maitra^9,*, Akbar Hossain^10,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1781-1804, 2024, DOI:10.32604/phyton.2024.048992 - 30 August 2024

Abstract Grass pea (Lathyrus sativus L.) is an imperative food crop cultured in dryland agricultural ecology. It is a vital source of dietary protein to millions of populaces living in low-income countries in South-East Asia and Africa. This study highlights the improvement of genomic properties and their application in marker-trait relationships for 17 yield-related characters in 400 grass pea genotypes from China and Bangladesh. These characters were assessed via 56 polymorphic markers using general linear model (GLM) (P+G+Q) and mixed linear model (MLM) (P+G+Q+K) in the tassel software based on the linkage disequilibrium and population structure analysis.… More >

Yi Tang¹, Yajun Zhao², Zihan Jin³, Shengnan Wu^1,*, Zhijun Zhang⁴, Ju Zhou¹, Ling Zhou⁵

International Journal of Mental Health Promotion, Vol.26, No.7, pp. 559-568, 2024, DOI:10.32604/ijmhp.2024.050822 - 30 July 2024

Abstract This study aimed to investigate the relationship between mental health literacy (MHL) and workplace well-being (WWB) of Chinese grassroots civil servants, with regulatory emotional self-efficacy (RESE) and resilience as mediating variables. A questionnaire survey was conducted among Chinese grassroots civil servants, with a valid sample size of 2673 after excluding missing values and conducting relevant data processing. The PROCESS was used to examine the relationship between MHL, RESE, resilience, and WWB. The study found that MHL among grassroots civil servants was positively and significantly correlated with WWB (r = 0.73, p < 0.01). RESE partially mediated… More >

Lin Wang¹, Juan Zhao², Hu Song³, Xiaolong Xu^4,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1105-1135, 2024, DOI:10.32604/cmc.2024.048688 - 25 April 2024

Abstract In smart classrooms, conducting multi-face expression recognition based on existing hardware devices to assess students’ group emotions can provide educators with more comprehensive and intuitive classroom effect analysis, thereby continuously promoting the improvement of teaching quality. However, most existing multi-face expression recognition methods adopt a multi-stage approach, with an overall complex process, poor real-time performance, and insufficient generalization ability. In addition, the existing facial expression datasets are mostly single face images, which are of low quality and lack specificity, also restricting the development of this research. This paper aims to propose an end-to-end high-performance multi-face… More >

YANG LI^1,2, JIAN LIU^1,3,*, YUEDI HU^1,2, CHENGZHI CONG^1,2, YIMING CHEN^1,2, QIAO ZHOU^1,2

BIOCELL, Vol.48, No.1, pp. 9-19, 2024, DOI:10.32604/biocell.2023.045862 - 30 January 2024

Abstract Rheumatoid arthritis (RA) is a prevalent autoimmune disease whose main features include chronic synovial inflammation, bone destruction, and joint degeneration. Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA. Neutrophil extracellular traps (NETs), a meshwork of DNA-histone complexes and proteins released by activated neutrophils, are widely involved in the pathophysiology of autoimmune diseases, especially RA, in addition to playing a key role in the neutrophil innate immune response. NETs have been found to be an important source of citrullinated autoantigen antibodies and More > Graphic Abstract

Muhammad Sabar^1,2,#, Shahzad Amir Naveed^1,3,4,#,*, Shahid Masood Shah⁵, Abdul Rehman Khan⁵, Muhammad Musaddiq Shah⁶, Tahir Awan¹, Muhammad Ramzan Khan³, Zaheer Abbas³, Muhammad Arif^1,7,*

Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1421-1438, 2023, DOI:10.32604/phyton.2023.025801 - 09 March 2023

Abstract Drought is one of the major abiotic threat to rice production in the context of climate change. Super Basmati is an elite, fine grain basmati rice variety grown in Punjab, Pakistan. Due to drought sensitive in nature, its yield has been facing an alarming situation in production because of gradual decrease in irrigated water for a couple of years. Three reported novel QTLs for drought tolerance were selected for incorporation into Super Basmati by employing marker assisted selection strategy. IR55419-04 with novel QTLs was used as a donor parent. Foreground selection was performed by applying… More >