YUQING HE1, LI GUO1, JUAN DING1, HAOWEN LV1, QUANRUI MA1, CHEN LI1, YU SHAO1, QIANG LIU1, CHUN ZHANG1, HAO YANG1,2,*, JUAN LIU1,*
BIOCELL, Vol.45, No.2, pp. 417-426, 2021, DOI:10.32604/biocell.2021.013842
Abstract Schizophrenia is a common and serious mental illness characterized by severe impairments in thinking,
emotions, and behaviors. Usually, the cognitive deficits of schizophrenia are closely associated with abnormal
neurogenesis due to the hypofunction of certain neural receptors such as N-methyl-D-aspartate receptors (NMDARs),
which mediates neurotransmission. However, little is known about the involvement of NMDAR1 in regulating
hippocampal neurogenesis in schizophrenia. In the current study, we present evidence suggesting that NMDAR1
regulates hippocampal neurogenesis as lentivirus-mediated shRNA silencing NMDAR1 gene or blocking with MK-801
results in abnormal neurogenesis consistently found in schizophrenia. The important finding was clearly
demonstrated by the multiparametric… More >
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