Dong Hwan Ho^1,*, Minhyung Lee^2,3, Daleum Nam¹, Hyejung Kim¹, Janghwan Kim^2,3, Mi Kyoung Seo^4,5, Sung Woo Park^4,5, Ilhong Son^1,6,*

BIOCELL, Vol.49, No.7, pp. 1225-1244, 2025, DOI:10.32604/biocell.2025.065486 - 25 July 2025

Abstract Background: Parkinson’s disease (PD) is a common neurodegenerative disease, characterized by symptoms like tremors, muscle rigidity, and slow movement. The main cause of these symptoms is the loss of dopamine-producing neurons in a brain area called the substantia nigra. Various genetic and environmental factors contribute to this neuronal loss. Once symptoms of PD begin, they worsen with age, which also impacts several critical cellular processes. Leucine-rich repeat kinase 2 (LRRK2) is a gene associated with PD. Certain mutations in LRRK2, such as G2019S, increase its activity, disrupting cellular mechanisms necessary for healthy neuron function, including… More >

YU ZHANG^1,2, QINGKUN WANG², YUE HAN², JUNJIE PIAO^2,*, XIUYING JIN^1,2,*

Oncology Research, Vol.33, No.8, pp. 1933-1945, 2025, DOI:10.32604/or.2025.063395 - 18 July 2025

Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

YOUYANG HU^1,#, YISHU LUO^1,#, TIANYUE XIE¹, YUEHUA CHEN^1,2, JUN ZHAO¹, WEICHAO JI³, ZHIWEI YAN³, SITONG QIU³, KEXIN GAO³, HAIXIA ZHU⁴, LIMIN MA^1,*, QIYOU YIN^1,*

Oncology Research, Vol.33, No.7, pp. 1695-1708, 2025, DOI:10.32604/or.2025.060021 - 26 June 2025

Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >

Federico Licastro^*

BIOCELL, Vol.49, No.6, pp. 981-989, 2025, DOI:10.32604/biocell.2025.062303 - 24 June 2025

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease causing the most frequent form of dementia in old age. AD etiology is still uncertain and deposition of abnormal proteins in the brain along with chronic neuroinflammation have been suggested as pathogenic mechanisms of neuronal death. Infections by exogenous neurotropic virus, endogenous retrovirus reactivation, infections by other microbes, and air pollutants may either induce neurodegeneration or activate brain inflammation. Up to 8% of the human genome has a retroviral origin. These ancient retroviruses, also called human endogenous retroviruses, are associated with a clinical history of several neurodegenerative diseases.… More >

Xinxin Chen¹, Fuxin Li¹, Jingyu Jia¹, Yajing Tian¹, Xin Li^1,2,3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 825-842, 2025, DOI:10.32604/phyton.2025.062015 - 31 March 2025

Abstract In plants, transcription factor (TF) family LATERAL ORGAN BOUNDARIES DOMAIN (LBD) has been identified to be involved in the ripening and senescence processes of fruits. However, the function of LBD in Hylocereus undatus (Haw.) Britton & Rose (H. undatus) has not been reported yet. Through transcriptomic analysis, virus-induced gene silencing (VIGS) technology, and RT-qPCR validation, we investigated the role of the LBD TFs in the senescence of H. undatus. Transcriptomic analysis revealed that HuLBD1 is a key transcription factor of the LBD family regulating H. undatus senescence. After silencing HuLBD1, 5075 differentially expressed genes (DEGs) were identified. GSEA results showed… More >

Antonio Rodrigues da Cunha Neto¹, Alexandra dos Santos Ambrósio¹, Arlinda de Jesus Rodrigues Resende¹, Breno Régis Santos¹, Michele Carla Nadal^2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 539-560, 2025, DOI:10.32604/phyton.2025.061776 - 31 March 2025

Abstract Cytokinins are plant hormones that are essential for plant growth and development and are involved in a variety of processes. They are synthesized by the modification of adenine with an isoprenoid chain, resulting in cytokinins such as isopentenyladenine and zeatin. The levels of these hormones are regulated by conjugation, degradation and oxidation processes that modulate their activity. Cytokinins are perceived by cells through specific receptors that, when activated, trigger signaling cascades responsible for regulating the expression of genes critical for development. In addition, cytokinins interact with other hormones, such as auxins, to coordinate plant growth… More >

Juan Cheng^1,#, Zhiwei Zhao^2,#, Ling Wang¹, Jirui Wen¹, Yali Miao^3,*, Jiang Wu^1,*

BIOCELL, Vol.49, No.2, pp. 335-348, 2025, DOI:10.32604/biocell.2025.059573 - 28 February 2025

Abstract Objectives: Recently, pre-/post-operative Local Estrogen Therapy (LET) has shown effectiveness in alleviating Pelvic Organ Prolapse (POP) symptoms in clinical therapy. However, there is a lack of scientific evidence to support these claims. Therefore, we aimed to explore the anti-senescence effects and mechanisms of 17β-estradiol (E2) on POP-derived fibroblasts. Methods: The primary fibroblast cells were isolated and cultured from the surgical samples of postmenopausal women clinically diagnosed with pelvic organ prolapse (POP) at stages III-IV (quantified using the POP-Q system) and without any other treatment within 6 months. (n = 12, age 50–75). Colorimetric Cell Counting… More >

HYEON JU LEE¹, CHANG SEOP LEE¹, SI HOON KIM¹, SOOKYUNG KIM¹, JEONG MI KIM¹, SUN-WHA IM¹, YU-JIN JUNG², SEUNG-PYO HONG³, HYUNJUNG LEE³, JONG-IL KIM^3,4,5, JEONG A. HAN^1,*

BIOCELL, Vol.48, No.10, pp. 1455-1464, 2024, DOI:10.32604/biocell.2024.054538 - 02 October 2024

Abstract Objective: Transformation from normal cells to malignant cells is the basis for tumorigenesis. While this cell transformation is known to result from aberrant activation or inactivation of associated genes, these genes have not yet been fully identified. In addition, DNAJs, proteins with a J domain, are known to be molecular co-chaperones, but their cellular functions remain largely unexplored. In this context, we here identified DNAJA4, DNAJB11, and DNAJC10 as pro-transforming genes and elucidated their action mechanisms. Methods: Senescence-associated (SA)-β-galactosidase staining and western blotting were used to analyze cellular senescence and protein expression. Soft agar assay was used… More >

Rafael Ariza-Flores¹, Rafael Ambriz-Cervantes², Pedro Cadena-Iñiguez³, Luis A. Gálvez-Marroquín⁴, Miguel A. Cano-García^4,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1805-1818, 2024, DOI:10.32604/phyton.2024.050093 - 30 August 2024

Abstract The objective of this study consisted of evaluating the effect of the application of chitosan (Q), 1-methylcyclopropene (1-MCP) under two controlled temperatures on some physical, physiological, and chemical parameters contributing to the quality of Persian lime Citrus latifolia fruits. Eight treatments were evaluated, resulting from the combination of four senescence retardant applications (Q, 1-MCP, 1-MCP + Q, and without application) on fruits stored at two temperatures (12/20°C). Epidermis color (luminosity, chromaticity, and hue), fruit appearance, respiration, weight loss, total juice content, total soluble solids, and titratable acidity were registered during the study. The results indicate that More >

JIANBO ZHOU^1,2,3, FENG WAN^2,4, BIN XIAO⁵, XIN LI¹, CHENG PENG^2,*, FU PENG^1,3,*

Oncology Research, Vol.32, No.5, pp. 943-953, 2024, DOI:10.32604/or.2023.044775 - 23 April 2024

Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC More > Graphic Abstract