Basharat Ullah¹, Umar Khan¹, Hafiz Abdul Wahab¹, Ilyas Khan^2,*, Dumitru Baleanu^3,4,5, Kottakkaran Sooppy Nisar⁶

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 947-960, 2021, DOI:10.32604/cmc.2020.012430 - 30 October 2020

Abstract The investigation of Thermal performance in nanofluids and hybrid nanofluids over a curved stretching infinite region strengthens its roots in engineering and industry. Therefore, the comparative thermal analysis in SiO₂–H₂O and (MoS₂–SiO₂)–H₂O is conducted over curved stretching surface. The model is reduced in the dimensional version via similarity transformation and then treated numerically. The velocity and thermal behavior for both the fluids is decorated against the preeminent parameters. From the analysis, it is examined that the motion of under consideration fluids declines against Fr and λ. The thermal performance enhances for higher volumetric fraction and λ. More >

KHAWAR ALI SHAHZAD^1,2,#, ZHONGJIE QIN^3,4,#, YAN LI^1,2,*, DELIN XIA^3,4,*

BIOCELL, Vol.44, No.2, pp. 137-145, 2020, DOI:10.32604/biocell.2020.08500 - 27 May 2020

Abstract Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role in the process of transforming force signals into intracellular chemical signals and subsequently triggering related physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses More >

Danyang Yue¹, Yijuan Fan¹, Juan Lu¹, Mengxue Zhang¹, Jin Zhou¹, Yuying Bai¹, Jun Pan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 144-144, 2019, DOI:10.32604/mcb.2019.07084

Abstract Mesenchymal Stem Cells (MSCs) are recruited to the musculoskeletal system following trauma [1] or chemicals stimulation [2]. The regulation of their differentiation into either bone or cartilage cells is a key question. The fluid shear stress (FSS) is of pivotal importance to the development, function and even the repair of all tissues in the musculoskeletal system [3]. We previously found that MSCs are sensitive enough to distinguish a slight change of FSS stimulation during their differentiation commitment to bone or cartilage cells, and the internal mechanisms. In detail, MSCs were exposed to laminar FSS linearly… More >

Jianxiong Xu¹, Lu Wang¹, Jinxuan Wang¹, Juhui Qiu^1,*, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 142-142, 2019, DOI:10.32604/mcb.2019.07273

Abstract Endothelial cell injured or dysfunction, which results lipid deposition and inflammation, is the key point to exacerbate the process of atherosclerosis [1, 2]. Meanwhile oscillatory shear stress is a key factor that results cell dysfunction in vascular disease [3, 4]. Previous research reported that P2Y12 plays a critical role in the development of atherosclerotic lesion through promoting smooth muscle cells migration [5]. As well P2Y12 stimulated the internalization and transendothelial transport of high density lipid. However, whether the P2Y12 induce atherosclerosis through endothelial cell remain elusive. In this study we firstly found P2Y12 were expressed… More >

Jian Shi^1,*, Baptiste Rode¹, David Beech¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 98-98, 2019, DOI:10.32604/mcb.2019.06939

Abstract The sensing of blood flow-evoked shear stress is critical in vascular development and maintenance of a healthy vasculature in the adult [1,2]. The identity of molecules which sense and transduce this force into appropriate vascular anatomy and function is therefore keenly sought. A central question is whether there is a force sensor protein (“receptor”) which directly detects the force, acting either alone or in complex with other proteins. Piezo1 channels are Ca²⁺-permeable non-selective cationic channels which are activated by membrane stretch. These channels are important for shear stress-sensing and vascular function in embryonic and adult mice.… More >

Biyue Liu^1,*, Dalin Tang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 25-26, 2019, DOI:10.32604/mcb.2019.06825

Abstract The blood flow and mass transport pattern of low-density lipoprotein (LDL) in a right coronary artery with two stenoses are studied. Computations were carried out under physiological conditions. Our results show a strong correlation between wall shear stress (WSS) and distribution patterns of LDL. More >

Liang Wang¹, Haibo Jia², Luping He², Rui Lv¹, Xiaoya Guo³, Chun Yang^4,5, Don P. Giddens^6,7, Habib Samady⁶, Akiko Maehara⁸, Gary S. Mintz⁸, Dalin Tang^1,*,5

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >

Yu Gao¹, Meiyue Wang¹, Yanting He¹, Lanlan Li¹, Xiaodong Cui¹, Min Cheng^1,*, Xiaoyun Zhang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 93-93, 2019, DOI:10.32604/mcb.2019.05758

Abstract This study examines the effects of P53 in transdifferentiation of endothelial progenitor cells (EPCs) into smooth muscle cells induced by oscillatory shear stress. Endothelial progenitor cells (EPCs) were planted on slide and treated with 4 dyne/cm2 oscillatory shear stress (OSS). Results showed that the expression P53 was decreased time dependent after OSS. The OSS also attenuated the endothelial cells marker vWF and CD31 expression but enhanced the marker of smooth muscle cell α-SMA and SM22 expression in EPCs. After EPCs were pretreated with P53 agonist, the changes of angiogenesis in vitro were detected by matrix More >

Xiumei Guan¹, Hong Li¹, Xin Li¹, Xiaoyun Zhang¹, Xiaodong Cui¹, Hong Yan¹, Yuzhen Wang², Shunmei Liu², Min Cheng^3,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 91-91, 2019, DOI:10.32604/mcb.2019.05755

Abstract Aims: Endothelial progenitor cells (EPCs) play an important role in postnatal angiogenesis and neovascularization. Previous studies have revealed shear stress could accelerate EPC proliferation, differentiation, migration and so on, which contribute to postnatal angiogenesis and neovascularization. Moreover, some studies indicate that autophagy actively participates angiogenesis by affecting EPC migration and differentiation. Here, we try to elucidate the possible roles of autophagy of EPC differentiation induced by shear stress. Methods and Results: EPCs were exposed to shear stress (12 dyne/cm²). And then the expression of autophagy markers, such as LC3Ⅱ/Ⅰ, P62andATG5, were analyzed using Western blot. The results… More >

Na Liu¹, Xiaoyun Zhang², Yuzhen Ding², Hong Li², Xiumei Guan², Min Cheng^2,*, Xiaodong Cui^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 87-87, 2019, DOI:10.32604/mcb.2019.05751

Abstract Objective: Endothelial progenitor cells (EPCs) play a vital role in postnatal vascular injury and repair, especially vasculogenesis and angiogenesis. The purpose of this study was to investigate the effect of laminar shear stress in attenuating the decreased-expression of complement regulatory protein CD59 and the mechanism of cytoskeleton F-actin. Methods: EPCs were isolated from human umbilical vein blood and planted on glass slides, which applied to the laminar shear stress force (12 dyne/cm2) in a high glucose (20 mM) culture environment. The gene and protein expression of CD59 were detected by SYBGreen quantitative PCR and fluorescence activated… More >