Damodharan Palaniappan1, Tan Kuan Tak2, K. Vijayan3, Balajee Maram4, Pravin R Kshirsagar5, Naim Ahmad6,*
CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4107-4127, 2025, DOI:10.32604/cmes.2025.073387
- 23 December 2025
Abstract A phase-aware cross-modal framework is presented that synthesizes UWF_FA from non-invasive UWF_RI for diabetic retinopathy (DR) stratification. A curated cohort of 1198 patients (2915 UWF_RI and 17,854 UWF_FA images) with strict registration quality supports training across three angiographic phases (initial, mid, final). The generator is based on a modified pix2pixHD with an added Gradient Variance Loss to better preserve microvasculature, and is evaluated using MAE, PSNR, SSIM, and MS-SSIM on held-out pairs. Quantitatively, the mid phase achieves the lowest MAE (98.76 ± 42.67), while SSIM remains high across phases. Expert review shows substantial agreement (Cohen’s More >