Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (5)
  • Open Access



    Roshan Devidas Bhagata,* , Samir J. Deshmukhsup>b

    Frontiers in Heat and Mass Transfer, Vol.19, pp. 1-11, 2022, DOI:10.5098/hmt.19.14

    Abstract Numerical analysis of liquid vapor slug flow in a vertically placed U-shaped closed capillary tube is carried out with family of hydrocarbon fluid like Acetone, Ethanol, Methanol and Pentane. A 3D computational domain has been developed for vertically placed U-shaped capillary tube sealed at both end with three small turns in evaporator section, two small and one large turn in condenser section. The diameter of vertically placed U-shaped capillary tube is taken as 2mm. The volume of fluid (VOF) approach, suitable model of K-epsilon is used to predict the behavior of liquid vapor slug flow… More >

  • Open Access


    Mitotic Arrest-Deficient Protein 2B Overexpressed in Lung Cancer Promotes Proliferation, EMT, and Metastasis

    Hua Zhang*, Xiuquan He, Wenfei Yu, Bingqing Yue, Ziting Yu, Ying Qin*

    Oncology Research, Vol.27, No.8, pp. 859-869, 2019, DOI:10.3727/096504017X15049209129277

    Abstract As the noncatalytic subunit of mammalian DNA polymerase, mitotic arrest-deficient protein 2B (MAD2B) has been reported to play a role in cell cycle regulation, DNA damage tolerance, gene expression, and carcinogenesis. Although its expression is known to be associated with poor prognosis in several types of human cancers, the significance of MAD2B expression in lung malignancies is still unclear. Our study showed that MAD2B expression significantly increased in lung cancer, especially in the metastatic tissues. We also found that knockdown of MAD2B inhibited the migration, invasion, and epithelial–mesenchymal transition of lung cancer cells in vitro More >

  • Open Access


    The AKT/GSK3β-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1

    Wei Wei*1, Xiao-Dong Ma†1, Guan-Min Jiang, Bin Shi§, Wen Zhong, Chun-Lei Sun§, Liang Zhao*, Yan-Jiao Hou*, Hao Wang*

    Oncology Research, Vol.28, No.4, pp. 423-438, 2020, DOI:10.3727/096504020X15877284857868

    Abstract Although oxaliplatin serves as one of the first-line drugs prescribed for treating colorectal cancer (CRC), the therapeutic effect is disappointing due to drug resistance. So far, the molecular mechanisms mediating oxaliplatin resistance remain unclear. In this study, we found the chemoresistance in oxaliplatin-resistant HCT116 cells (HCT116/OXA) was mediated by the upregulation of ERCC1 expression. In addition, the acquisition of resistance induced epithelial–mesenchymal transition (EMT) as well as the Slug overexpression. On the contrary, Slug silencing reversed the EMT phenotype, decreased ERCC1 expression, and ameliorated drug resistance. Further mechanistical studies revealed the enhanced Slug expression resulted More >

  • Open Access


    Knockdown of lncRNA XIST prevents the epithelial-mesenchymal transition of TGF-β2-induced human lens epithelial cells via miR-124/Slug axis


    BIOCELL, Vol.46, No.3, pp. 785-794, 2022, DOI:10.32604/biocell.2022.016167

    Abstract Posterior capsular opacification (PCO) is linked to the pathological process of lens epithelial cells, which includes proliferation, migration, and epithelial-mesenchymal transition (EMT). Our goal was to investigate whether long noncoding RNA (lncRNA) XIST contributes to EMT via targeting miR-124/Slug axis in TGF-β2-induced SRA01/04 cells. EMT was induced by stimulating SRA01/04 cells with 10 ng/mL TGF-β2 for 24 h, and PCO microenvironment was simulated. The expressions levels of lncRNA XIST, miR-124, and Slug were measured by real-time polymerase chain reaction (RT-PCR) and western blot. The role and mechanism of lncRNA XIST in promoting EMT of TGF-β2-treated… More >

  • Open Access


    Slug Flow Characteristics in Inclined and Vertical Channels

    Zhihui Wang1,2,3, Wei Luo1,2,3,*, Ruiquan Liao1,2,3, Xiangwei Xie4, Fuwei Han5, Hongying Wang6

    FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.5, pp. 583-595, 2019, DOI:10.32604/fdmp.2019.06847

    Abstract Horizontal well production technology gradually occupies a dominant position in the petroleum field. With the rise in water production in the later stage of exploitation, slug flow phenomena will exist in horizontal, inclined and even vertical sections of gas wells. To grasp the flow law of slug flow and guide engineering practice, the flow law of slug flow at various inclination angles (30°~90°) is studied by means of the combination of laboratory experiments (including high frequency pressure data acquisition system) and finite element numerical simulation. The results reveal that because of the delay of pressure… More >

Displaying 1-10 on page 1 of 5. Per Page