Hai Liu*, Xuanxuan Wang*, Aihua Huang†, Huaping Gao‡, Yikan Sun§, Tingting Jiang*,
Liming Shi*, Xianjie Wu¶, Qinghua Dong#, Xiaonan Sun*
Oncology Research, Vol.27, No.1, pp. 29-38, 2019, DOI:10.3727/096504018X15179694020751
Abstract Artemis is a key protein of NHEJ (nonhomologous end joining), which is the major pathway for the repair
of IR-induced DSBs in mammalian cells. However, the expression of Artemis in tumors and the influence of
silencing Artemis on tumor sensitivity to radiation have not been investigated fully. In this study, we investigated how the expression levels of Artemis may affect the treatment outcome of radiotherapy and chemotherapy in colorectal cancer cells. First, we found that the expression of Artemis is strong in some human rectal
cancer samples, being higher than in adjacent normal tissues using immunohistochemical staining. We then
knocked… More >
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