JIAWEI FU^1,2,3,#, CHUNSHUAI WU^1,2,3,#, GUANHUA XU^1,2,3, JINLONG ZHANG¹, YIQIU LI¹, CHUNYAN JI^1,2,3, ZHIMING CUI^1,2,3,*

BIOCELL, Vol.47, No.4, pp. 739-749, 2023, DOI:10.32604/biocell.2023.026881 - 08 March 2023

Abstract Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists of receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like protein, is believed to control a novel type of programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural cell damage, release of intracellular pro-inflammatory factors, lysosomal dysfunction and endoplasmic reticulum stress. Recent research indicates that More >

XUYI WANG¹, WEN ZHANG², LEI GAO², KUANXIN LI^1,3,*

BIOCELL, Vol.46, No.9, pp. 2065-2072, 2022, DOI:10.32604/biocell.2022.018265 - 18 May 2022

Abstract Background: Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, and there is currently no effective treatment for SCI because of its complicated pathophysiology. Bone marrow mesenchymal stem cells (BMSCs) have multidirectional differentiation abilities. Our study aims to explore the effects of bone morphogenetic protein 7 (BMP-7)-modified BMSCs transplantation on the repair of SCI in rats. Methods: In this study, a rat spinal cord injury model was established with the modified Allen method. Then, BMSCs transfected with the BMP7 gene were transplanted to treat the spinal cord injury in rats. Forty… More >

Min Rao¹, Yufeng Li^1,*, Hongye Liu², Isabel Wang³, Yongjun Ren⁴

Intelligent Automation & Soft Computing, Vol.34, No.1, pp. 455-466, 2022, DOI:10.32604/iasc.2022.027694 - 15 April 2022

Abstract The aim of spinal cord injury rehabilitation is to increase the independent ability of patients, so that patients can return to society and live a creative life. Regaining independence living is the primary goal of rehabilitation. Rehabilitation of patients with spinal cord injury is a long and lengthy process, which needs comprehensive dimensions support from medical workers, family members, and social support. At present, medical institutions and researchers mainly focus on the level of physical recovery and the treatment of complications in patients with spinal cord injury and pay less attention to social factors during… More >

XINFU FAN^1,2,#, JIE CHEN^3,#, ZONGMENG ZHANG^4,#, FANGHUI CHEN⁵, HAOSEN WANG⁶, YAFEI CAI⁶, JUN LI^7,*

BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269 - 07 February 2022

Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in… More >

RAMSHA SHAMS^1,2, NAREN L. BANIK^1,2,3,*, AZIZUL HAQUE^1,*

BIOCELL, Vol.45, No.6, pp. 1453-1457, 2021, DOI:10.32604/biocell.2021.017659 - 01 September 2021

Abstract Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the unfortunate complexity of the condition, and the difficulties of SCI may be furthered by the development of SCI-related complications, such as osteoporosis. SCI demonstrates two crucial stages for consideration: the primary stage and the secondary stage. While the primary stage is suggested to be immediate and irreversible, the secondary stage is proposed as a promising window of opportunity for… More >

Bernard E. Leduc

Canadian Journal of Urology, Vol.19, No.5, pp. 6432-6436, 2012

Abstract Introduction: The majority of men with a spinal cord injury (SCI) are infertile due to ejaculatory dysfunction and poor semen quality. The goal of this retrospective study is to present the outcomes of assisted reproductive technology (ART) in a group of couples with SCI male partners.
Materials and methods: A review was conducted of the records of 31 couples with SCI male partners who were treated at the Institut de réadaptation Gingras-Lindsay-de-Montréal, at PROCREA Cliniques or at a hospital center. A semen sample was obtained either by manual stimulation, penile vibratory stimulation, electroejaculation or testicular sperm extraction.… More >

Wally Mahfouz¹, Gilles Karsenty², Jacques Corcos¹

Canadian Journal of Urology, Vol.18, No.4, pp. 5787-5795, 2011

Abstract Introduction: The first application of botulinum toxin type A (BoNT-A) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. Since that first report by Dyskatra et al in 1988, the results of focal BTA injections into the sphincter, the bladder wall and lately into the prostate have raised the interest of the urology community in this promising new therapeutic modality. This is an evidence-based review of the current indications, techniques and outcomes of BTA injections into the urethral sphincter.
Materials and methods: The Medline database was searched for… More >

M. Gail Woodbury¹, Keith C. Hayes², Heather K. Askes²

Canadian Journal of Urology, Vol.15, No.3, pp. 4065-4071, 2008

Abstract Objective: To identify intermittent catheterization (IC) practices and factors associated with urinary tract infection (UTI) in community-dwelling people living with spinal cord injury (SCI) in Canada.
Study design: A national survey employing a 36-item self-report questionnaire that was mailed to members of the Canadian Paraplegic Association (CPA).
Results: There were 912 respondents with SCI of either traumatic or nontraumatic etiology. Fifty-five percent of the respondents used IC. The mean age of users (47 ± 14 years) was significantly younger than non-users (53 ± 13 years) and a greater percentage of males (57%) than females (50%) used IC. Of… More >

K. C. Hayes, K. Bassett-Spiers, R. Das, K. D. Ethans, C. Kagan, J. L. K. Kramer, T. Linsenmeyer, K. N. Moore, H. Razvi, G. Reid, J. S. Walter, J. W. L. Wilson

Canadian Journal of Urology, Vol.14, No.1, pp. 3416-3423, 2007

Abstract Objective: A multidisciplinary panel of experts from Canada and the United States was convened by the Ontario Neurotrauma Foundation (ONF) to establish research priorities in the area of urological care following spinal cord injury (SCI).
Design: The panel reviewed a synthesis of published literature in five areas of urology, identified emerging opportunities in the private and public sector, and used a modified Delphi approach to reach consensus on priorities for funding.
Results: The panel recommendations included: clinical trials of the safety and efficacy of M3 receptor specific anti-muscarinic agents for bladder hyperactivity in SCI patients; development and… More >

Bertil F. M. Blok, Gilles Karsenty, Jacques Corcos

Canadian Journal of Urology, Vol.13, No.5, pp. 3239-3243, 2006

Abstract Objective: To determine current trends in management and surveillance of the neurogenic bladder population by Canadian urologists who routinely work with and provide care for these patients.
Methods: A questionnaire was mailed to members of the Canadian Urological Association. The assessment and follow-up of upper and lower urinary tract function in neurogenic bladder patients, their optimal frequency and management of related infections were the topics of inquiry.
Results: One hundred and five of 602 urologists responded, for a response rate of 18%. Twenty-three (22%) of the respondents did not treat neurogenic bladder patients. Four out of five… More >