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  • Open Access

    REVIEW

    Large Language Models for Cybersecurity Intelligence: A Systematic Review of Emerging Threats, Defensive Capabilities, and Security Evaluation Frameworks

    Hamed Alqahtani1, Gulshan Kumar2,*

    CMC-Computers, Materials & Continua, Vol.87, No.3, 2026, DOI:10.32604/cmc.2026.077367 - 09 April 2026

    Abstract Large Language Models (LLMs) are becoming integral components of modern cybersecurity ecosystems, simultaneously strengthening defensive capabilities while giving rise to a new class of Artificial Intelligence–Generated Content (AIGC)-driven threats. This PRISMA-guided systematic review synthesises 167 peer-reviewed studies published between 2022 and 2025 and proposes a unified threat–defence–evaluation taxonomy as a central analytical framework to consolidate a previously fragmented body of research. Guided by this taxonomy, the review first examines AIGC-enabled threats, including automated and highly personalised phishing, polymorphic malware and exploit generation, jailbreak and adversarial prompting, prompt-injection attack vectors, multimodal deception, persona-steering attacks, and large-scale… More >

  • Open Access

    REVIEW

    Federated Deep Learning in Intelligent Urban Ecosystems: A Systematic Review of Advancements and Applications in Smart Cities, Homes, Buildings, and Healthcare Systems

    Muhammad Adnan Tariq1, Sunawar Khan2, Tehseen Mazhar2,3, Tariq Shahzad4, Sahar Arooj5, Khmaies Ouahada6, Muhammad Adnan Khan7,*, Habib Hamam8,9,10,11

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2026.078672 - 30 March 2026

    Abstract The contemporary smart cities, smart homes, smart buildings, and smart health care systems are the results of the explosive growth of Internet of Things (IoT) devices and deep learning. Yet the centralized training paradigms have fundamental issues in data privacy, regulatory compliance, and ownership silo alongside the scaled limitations of the real-life application. The concept of Federated Deep Learning (FDL) is a privacy-by-design method that will enable the distributed training of machine learning models among distributed clients without sharing raw data and is suitable in heterogeneous urban settings. It is an overview of the privacy-preserving… More >

  • Open Access

    REVIEW

    Malware Detection and AI Integration: A Systematic Review of Current Trends and Future Directions

    M. Mohsin Raza1,#, Muhammad Umair1,#, Imran Arshad Choudhry1, Muhammad Qasim1, Muhammad Tahir Naseem2,*, Mamoona Naveed Asghar3, Daniel Gavilanes4,5,6,7, Manuel Masias Vergara4,8,9, Imran Ashraf10,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.3, 2026, DOI:10.32604/cmes.2025.074164 - 30 March 2026

    Abstract Over the past decade, the landscape of cybersecurity has been increasingly shaped by the growing sophistication and frequency of malware attacks. Traditional detection techniques, while still in use, often fall short when confronted with modern threats that use advanced evasion strategies. This systematic review critically examines recent developments in malware detection, with a particular emphasis on the role of artificial intelligence (AI) and machine learning (ML) in enhancing detection capabilities. Drawing on literature published between 2019 and 2025, this study reviews 105 peer-reviewed contributions from prominent digital libraries including IEEE Xplore, SpringerLink, ScienceDirect, and ACM… More >

  • Open Access

    REVIEW

    Investigating the Mental Health of Left-Behind Children in China’s Rural Areas: A Systematic Review Approach

    Jian Li1,*, Yide Chen2, Xinyi Zhao3, Eryong Xue3,*

    International Journal of Mental Health Promotion, Vol.28, No.3, 2026, DOI:10.32604/ijmhp.2026.073286 - 31 March 2026

    Abstract Background: The mobility of people in rural areas may lead to more and more left-behind children (LBC) appearing, and being an LBC brings a lot of risks to mental health, which could greatly hinder children’s development and undermine their happiness and safety in life. Previous scholars have conducted plenty of studies that focused on Chinese rural LBCs’ mental health issues, such as what they exactly look like and some potential factors, but there remains a paucity of reviews about the relationship among certain mental health issues. We will try to figure out how the most common… More >

  • Open Access

    REVIEW

    Surgery Alone Treatment vs. Surgery with Adjuvant Therapy for Laryngeal Mucoepidermoid Cancer: A Systematic Review

    Francesco Chiari1,*, Giovanni Motta2, Daria Maria Filippini3, Claudio Donadio Caporale1, Pierre Guarino1

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073086 - 23 March 2026

    Abstract Objective: Mucoepidermoid carcinoma (MEC) of the larynx is an extremely rare malignancy, accounting for less than 1% of primary laryngeal tumors. The optimal role of adjuvant therapy, particularly radiotherapy (RT), remains unclear due to limited evidence. This systematic review aimed to evaluate oncologic outcomes and the impact of adjuvant treatment in patients with early- and advanced-stage laryngeal MEC. Methods: A systematic literature search was performed according to PRISMA 2020 guidelines in PubMed/Embase, Scopus, and Cochrane for studies published up to 31 July 2025. Results: Twenty-two studies, encompassing 55 patients, were included. Early-stage (T1–T2) patients (n =… More >

  • Open Access

    REVIEW

    Ferroptosis as a Translational Axis in Small Cell Lung Cancer: A Systematic Review of Redox Pathways and Precision Oncology Prospects

    Donatella Coradduzza1,#, Anna La Salvia2,#, Giuseppe Fanciulli3, Maria Rosaria De Miglio3,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073045 - 23 March 2026

    Abstract Background: An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC). The systematic review aimed to summarize the characteristics of ferroptosis from its pathogenetic role to translational therapeutic implications in SCLC. Methods: This systematic review, registered in PROSPERO (CRD420251090058), followed PRISMA 2020 guidelines. Comprehensive research of PubMed, Scopus, and Web of Science was performed for studies published between January 2010 and July 2025 investigating ferroptosis mechanisms, genetic or pharmacological modulation, or molecular profiling in SCLC. Two reviewers independently performed data extraction and quality… More >

  • Open Access

    REVIEW

    Phishing, Vulnerabilities, and AI Defense: A Systematic Review of Cybersecurity Challenges and GRU-Based Mitigation Strategies in Digital Microfinance Institutions

    Richard Mathenge*, Catherine Mukunga, Ephantus Mwangi

    Journal of Cyber Security, Vol.8, pp. 129-151, 2026, DOI:10.32604/jcs.2026.077183 - 11 March 2026

    Abstract The rapid digitization of microfinance institutions (MFIs) has strengthened financial inclusion but has simultaneously increased exposure to phishing attacks and other cybersecurity threats driven by organizational, technical, and human vulnerabilities. Grounded in socio-technical systems theory, this systematic analysis evaluates AI-based mitigation strategies, with particular emphasis on gated recurrent unit (GRU) architectures. It compares them with Transformer and LSTM models. GRUs are prioritized due to their computational efficiency and suitability for low-resource environments typical of digital MFIs. Following PRISMA 2020 guidelines, 32 empirical studies published between January 2012 and April 2025 were analyzed from the Web… More >

  • Open Access

    REVIEW

    Association between periodontal disease and prostatic disease: a systematic review and meta-analysis of observational studies

    Qiang Li1, Lan Wu2, Yi Zhang1, Di Huang3, Song Ou-Yang1, Jia-Yu Yang3, Bing-Hui Li3,*, Xian-Tao Zeng1,3,4,5,*

    Canadian Journal of Urology, Vol.33, No.1, pp. 7-20, 2026, DOI:10.32604/cju.2026.076741 - 28 February 2026

    Abstract Objective: Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases, which prompted us to explore the potential association. To evaluate whether periodontal disease is associated with an increased risk of prostatic disease, including prostate cancer, benign prostatic hyperplasia (BPH), and prostatitis. Methods: A systematic search of observational studies concerning the relationship between periodontal disease and prostatic disease was performed in online databases PubMed, Embase, Web of Science, Scopus, CENTRAL, CNKI, and WanFang. Searches were conducted from database inception to 31 July 2025. Pooled hazard ratio… More >

  • Open Access

    REVIEW

    Artificial intelligence assisted 3D in the robotic urooncology? A systematic review and narrative synthesis of current applications, challenges and future directions

    Bara Barakat1,*, Bilal Al-Absi1, Boris Hadaschik2, Christian Rehme2, Samer Schakaki3, Joerg Bauer1

    Canadian Journal of Urology, Vol.33, No.1, pp. 105-116, 2026, DOI:10.32604/cju.2026.071284 - 28 February 2026

    Abstract Background: Artificial intelligence (AI)-assisted three-dimensional (3D) surgical platforms, integrated with augmented reality, have the potential to improve intraoperative anatomical recognition and provide surgeons with an immersive, dynamic operating environment during uro-oncological procedures. This review aims to examine the current applications of AI in robotic uro-oncology, with a particular focus on its role in facilitating intraoperative navigation during complex surgeries. Methods: A systematic literature search was performed across PubMed, the National Library of Medicine, MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Google Scholar to identify relevant studies published up to July 2025.… More >

  • Open Access

    REVIEW

    Intervention Characteristics to Improve Stress Coping in Healthcare Students: A Systematic Review and Meta-Analysis

    Natalie Y. Luo1, Edie L. Sperling2,*, Juliette Lum2

    International Journal of Mental Health Promotion, Vol.28, No.2, 2026, DOI:10.32604/ijmhp.2026.074948 - 27 February 2026

    Abstract Objectives: Healthcare students experience significant stress due to their rigorous graduate school curricula. These levels of stress are associated with higher risks of depression, self-harm, and exhaustion. Coping interventions have been shown to help students develop healthy stress coping strategies. The purpose of this systematic review and meta-analysis was to examine the diverse array of coping interventions and what characteristics of coping interventions were most effective at decreasing stress among healthcare students. Methods: Any intervention designed to address coping for academic stress was included among medical, dental, nursing, physician assistant, allied health, veterinary, psychology, etc. students.… More >

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