SEAN J. O’SULLIVAN^1,2,*

BIOCELL, Vol.46, No.1, pp. 7-11, 2022, DOI:10.32604/biocell.2022.017680

Abstract The development of effective treatments for psychiatric disease has been disappointing in recent decades given the advancements in neuroscience. Moreover, rising rates of mental illness such as addiction and depression compel scientists and physicians to discover novel and creative solutions. One such approach that has proven effective is systems neuroscience: A focus on networks as opposed to mechanism. Further, investigation at the single-cell and circuit level is likely to be fruitful in such endeavors as this resolution describes the functional psychopathology that allows for intervention. More >

Hong Qian^∗, Hao Ge^†

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 1-30, 2012, DOI:10.3970/mcb.2012.009.001

Abstract Biochemical reaction systems in mesoscopic volume, under sustained environmental chemical gradient(s), can have multiple stochastic attractors. Two distinct mechanisms are known for their origins: (a) Stochastic single-molecule events, such as gene expression, with slow gene on-off dynamics; and (b) nonlinear networks with feedbacks. These two mechanisms yield different volume dependence for the sojourn time of an attractor. As in the classic Arrhenius theory for temperature dependent transition rates, a landscape perspective provides a natural framework for the system's behavior. However, due to the nonequilibrium nature of the open chemical systems, the landscape, and the attractors it represents, are all themselves… More >