ZIPENG LIN1,#, CHUXI TANG1,#, LE KANG2, GUANXI LAI1, SHIWEN LIU1, YIXIANG WU1, HUIQUN TIAN3,*, SONG LIU1,4,5,*
BIOCELL, Vol.47, No.10, pp. 2217-2232, 2023, DOI:10.32604/biocell.2023.030233
Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE
family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and
apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved
functional domains, such as the death effector domain (DED)-like domain but displayed different roles and
mechanisms in different biological activities. For example, while TIPE is primarily associated with tumor progression
and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. TIPE2 has multiple roles in
tumor progression regulation, and antitumor drug… More >
Graphic Abstract
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