CHUYAO WANG1,2,#, CHUAN LU2,#, LUXIANG ZOU2,*, DONGMEI HE2,*
BIOCELL, Vol.47, No.6, pp. 1293-1306, 2023, DOI:10.32604/biocell.2023.028199
Abstract Background: Temporomandibular joint osteoarthritis (TMJOA) is an end-stage disease that seriously affects
the patients’ quality of life. Molecular insights in advancing our understanding of TMJOA are the need of the hour.
Methods: We performed RNA high-throughput sequencing and bioinformatics analysis of differentially expressed
(DE) long non-coding RNA (lncRNAs), microRNAs (miRNAs), and messenger RNA (mRNAs) in human synovial
TMJOA tissues. Firstly, synovium samples of TMJOA patients and non-TMJOA controls were collected for highthroughput sequencing of lncRNAs, miRNAs, and mRNAs. We then performed biological function analysis of the top
100 mRNAs with more than 2-fold differential expression, and their upstream regulated miRNAs… More >
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