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  • Open Access


    Prenatal heart block screening in mothers with SSA/SSB autoantibodies: Targeted screening protocol is a cost‐effective strategy

    Patrick D. Evers1,*, Tarek Alsaied1,2,*, Jeffrey B. Anderson1, James F. Cnota1, Allison A. Divanovic1

    Congenital Heart Disease, Vol.14, No.2, pp. 221-229, 2019, DOI:10.1111/chd.12713

    Abstract Objective: Maternal anti-Ro/SSA and anti-La/SSB antibodies can lead to fetal complete heart block (CHB). Current guidelines recommend weekly echocardiographic screening between 16 and 28 weeks gestation. Given the cost of screening and the rarity of conduction abnormalities in fetuses of mothers with low anti-Ro levels (<50 U/mL), we sought to identify a strategy that optimizes resource utilization.
    Design: Decision analysis cost-utility modeling was performed for three screening paradigms: “standard screening” (SS) in which mid-gestation mothers are screened weekly, “limited screening” (LS) in which fetal echocardiograms are avoided unless the fetus develops bradycardia, and “targeted screening by maternal… More >

  • Open Access


    Strategy Selection for Moving Target Defense in Incomplete Information Game

    Huan Zhang1, Kangfeng Zheng1, *, Xiujuan Wang2, Shoushan Luo1, Bin Wu1

    CMC-Computers, Materials & Continua, Vol.62, No.2, pp. 763-786, 2020, DOI:10.32604/cmc.2020.06553

    Abstract As a core component of the network, web applications have become one of the preferred targets for attackers because the static configuration of web applications simplifies the exploitation of vulnerabilities by attackers. Although the moving target defense (MTD) has been proposed to increase the attack difficulty for the attackers, there is no solo approach can cope with different attacks; in addition, it is impossible to implement all these approaches simultaneously due to the resource limitation. Thus, the selection of an optimal defense strategy based on MTD has become the focus of research. In general, the… More >

  • Open Access


    Observability Analysis in Parameters Estimation of an Uncooperative Space Target

    Xianghao Hou1, *, Gang Qiao1

    CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.1, pp. 175-205, 2020, DOI:10.32604/cmes.2020.08452

    Abstract To study the parameter estimating effects of a free-floating tumbling space target, the extended Kalman filter (EKF) scheme is utilized with different high-nonlinear translational and rotational coupled kinematic & dynamic models on the LIDAR measurements. Applying the aforementioned models and measurements results in the situation where one single state can be estimated differently with varying accuracies since the EKFs based on different models have different observabilities. In the proposed EKFs, the traditional quaternions based kinematics and dynamics and the dual vector quaternions (DVQ) based kinematics and dynamics are used for the modeling of the relative… More >

  • Open Access


    p53 siRNA promotes autophagy of U2OS cells through its target gene Rap2B

    Heya QIAN1,§, Yan YAN2,§, Zhengjie SHEN1, Lixian XU1, Yun ZUO1, Tao ZHU3,*, Yanan CHEN1,*

    BIOCELL, Vol.43, No.4, pp. 321-326, 2019, DOI:10.32604/biocell.2019.07992

    Abstract The present study aims to explore the effects of p53 and its target gene Rap2B on the autophagy of U2OS cells. U2OS cells were treated with siRNA against p53, Rap2B, and PLCε. Relative expressions of p53, Rap2B, and PLCε were determined using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Levels of IP3 in the cells were determined using Enzyme-linked Immunosorbent Assay (ELISA). Levels of Ca2+ were detected using Flow cytometry. Fluorescence microscopy was used to observe the autophagy of cells. Knockdown of p53 significantly decreased the expressions of Rap2B protein. Additionally, knockdown of p53 More >

  • Open Access


    Force-induced Unfolding of the Focal Adhesion Targeting Domain and the Influence of Paxillin Binding

    M.R. Kaazempur Mofrad1,2, J. Golji2, N.A. Abdul Rahim2, R.D. Kamm3

    Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 253-266, 2004, DOI:10.3970/mcb.2004.001.253

    Abstract Membrane-bound integrin receptors are linked to intracellular signaling pathways through focal adhesion kinase (FAK). FAK tends to colocalize with integrin receptors at focal adhesions through its C-terminal focal adhesion targeting (FAT) domain. Through recruitment and binding of intracellular proteins, FAs transduce signals between the intracellular and extracellular regions that regulate a variety of cellular processes including cell migration, proliferation, apoptosis and detachment from the ECM. The mechanism of signaling through the cell is of interest, especially the transmission of mechanical forces and subsequent transduction into biological signals. One hypothesis relates mechanotransduction to conformational changes in More >

  • Open Access


    Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants: Physiological Mechanism, Molecular Interaction and Signaling

    Mirza Hasanuzzaman1,*, Aditya Banerjee2, M. H. M. Borhannuddin Bhuyan3,4, Aryadeep Roychoudhury2,*, Jubayer Al Mahmud5 and Masayuki Fujita3

    Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 185-221, 2019, DOI:10.32604/phyton.2019.07559

    Abstract In the era of climate change, abiotic stresses (e.g., salinity, drought, extreme temperature, flooding, metal/metalloid(s), UV radiation, ozone, etc.) are considered as one of the most complex environmental constraints that restricts crop production worldwide. Introduction of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint, and to produce these types of tolerant crops. Several bioengineering mechanisms involved in stress signaling are being adopted in this regard. One example of this kind of manipulation is the osmotic adjustment. The quarternary ammonium compound glycinebetaine (GB), also originally referred to as betaine is a methylated… More >

  • Open Access


    Structural analysis of a composite target-drone wing

    Joong-Jin Kim, Jin-Hwe Kweon1, Jin-Ho Choi, Jong-Su Han

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.12, No.2, pp. 41-42, 2009, DOI:10.3970/icces.2009.012.041

    Abstract Target-drone is an unmanned remotely controlled aerial vehicle and usually used for shooting training for anti-aircraft screws. Traditional target-drones have been generally manufactured from aluminum and/or wood. Recently, composite materials have been replacing them in virtue of their high strength-to-weight and stiffness-to-weight ratios. In particular, glass fiber-based composite materials are popular for the target-drone level vehicles because of the material cost and fabrication convenience.
    In this paper, as a part of the development activities for a complete target-drone vehicle, the stress analysis results are presented for a 685cc engine target-drone composite aerial vehicle wing. Composite materials… More >

  • Open Access


    in silico Method for the Identification of Mycobacterial sp. Potential Drug Targets

    Ashutosh Singh1, Shruti Mishra2, Dhwani Raghav1, Asheesh shanker1, Vinay Sharma1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.6, No.2, pp. 119-124, 2008, DOI:10.3970/icces.2008.006.119

    Abstract Drug resistance has increased the pace of war against the ever-growing challenge of mycobacterial infections particularly with the growing menace of tuberculosis (TB).Previous studies reported several essential and virulent genes of mycobacterium like virS gene and mymA operon[1] through experimental approaches. However, Post genomic approach applied for the identification of targets for tuberculosis which includes the comparison of Mycobacterium tuberculosis CDC1551 proteome against database of essential genes and proteome of Homo sapiens. A total of approx 4000 proteins were studied and compared and 19 proteins were found to possess potentiality to call as Targets. More >

  • Open Access


    A study of HID light reflector design of a streetlight

    Shy-Pin Cuo1, Dein Shaw2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 199-200, 2009, DOI:10.3970/icces.2009.009.199

    Abstract The purpose of this study is to present the process of development of HID (High Intensity Discharge) light reflector of a streetlight. The new application of HID light source for streetlight product is proposed in this study, the advantages of HID include low power consumption and single point light source emitting. The study includes the introduction of HID streetlight structure, the lighting efficiency comparison of various light sources (ex. High Pressure Sodium-lamp ``HPS'', High Bright LED ``HB LED'', etc\ldots ), and the design of streetlight reflector. The emphases of the experiment are focused at light… More >

  • Open Access


    Pose Estimation of Space Targets Based on Model Matching for Large-Aperture Ground-Based Telescopes

    Zhengwei Li1,2, Jianli Wang1,*, Tao Chen1, Bin Wang1, Yuanhao Wu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.2, pp. 271-286, 2018, DOI:10.31614/cmc.2018.04005

    Abstract With the development of adaptive optics and post restore processing techniques, large aperture ground-based telescopes can obtain high-resolution images (HRIs) of targets. The pose of the space target can be estimated from HRIs by several methods. As the target features obtained from the image are unstable, it is difficult to use existing methods for pose estimation. In this paper a method based on real-time target model matching to estimate the pose of space targets is proposed. First, the physically-constrained iterative deconvolution algorithm is used to obtain HRIs of the space target. Second, according to the More >

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