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  • Open Access

    ARTICLE

    p53 siRNA promotes autophagy of U2OS cells through its target gene Rap2B

    Heya QIAN1,§, Yan YAN2,§, Zhengjie SHEN1, Lixian XU1, Yun ZUO1, Tao ZHU3,*, Yanan CHEN1,*

    BIOCELL, Vol.43, No.4, pp. 321-326, 2019, DOI:10.32604/biocell.2019.07992

    Abstract The present study aims to explore the effects of p53 and its target gene Rap2B on the autophagy of U2OS cells. U2OS cells were treated with siRNA against p53, Rap2B, and PLCε. Relative expressions of p53, Rap2B, and PLCε were determined using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Levels of IP3 in the cells were determined using Enzyme-linked Immunosorbent Assay (ELISA). Levels of Ca2+ were detected using Flow cytometry. Fluorescence microscopy was used to observe the autophagy of cells. Knockdown of p53 significantly decreased the expressions of Rap2B protein. Additionally, knockdown of p53 significantly decreased the mRNA… More >

  • Open Access

    ARTICLE

    Force-induced Unfolding of the Focal Adhesion Targeting Domain and the Influence of Paxillin Binding

    M.R. Kaazempur Mofrad1,2, J. Golji2, N.A. Abdul Rahim2, R.D. Kamm3

    Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 253-266, 2004, DOI:10.3970/mcb.2004.001.253

    Abstract Membrane-bound integrin receptors are linked to intracellular signaling pathways through focal adhesion kinase (FAK). FAK tends to colocalize with integrin receptors at focal adhesions through its C-terminal focal adhesion targeting (FAT) domain. Through recruitment and binding of intracellular proteins, FAs transduce signals between the intracellular and extracellular regions that regulate a variety of cellular processes including cell migration, proliferation, apoptosis and detachment from the ECM. The mechanism of signaling through the cell is of interest, especially the transmission of mechanical forces and subsequent transduction into biological signals. One hypothesis relates mechanotransduction to conformational changes in intracellular proteins in the force… More >

  • Open Access

    REVIEW

    Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants: Physiological Mechanism, Molecular Interaction and Signaling

    Mirza Hasanuzzaman1,*, Aditya Banerjee2, M. H. M. Borhannuddin Bhuyan3,4, Aryadeep Roychoudhury2,*, Jubayer Al Mahmud5 and Masayuki Fujita3

    Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 185-221, 2019, DOI:10.32604/phyton.2019.07559

    Abstract In the era of climate change, abiotic stresses (e.g., salinity, drought, extreme temperature, flooding, metal/metalloid(s), UV radiation, ozone, etc.) are considered as one of the most complex environmental constraints that restricts crop production worldwide. Introduction of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint, and to produce these types of tolerant crops. Several bioengineering mechanisms involved in stress signaling are being adopted in this regard. One example of this kind of manipulation is the osmotic adjustment. The quarternary ammonium compound glycinebetaine (GB), also originally referred to as betaine is a methylated glycine derivative. Among the betaines,… More >

  • Open Access

    ABSTRACT

    Structural analysis of a composite target-drone wing

    Joong-Jin Kim, Jin-Hwe Kweon1, Jin-Ho Choi, Jong-Su Han

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.12, No.2, pp. 41-42, 2009, DOI:10.3970/icces.2009.012.041

    Abstract Target-drone is an unmanned remotely controlled aerial vehicle and usually used for shooting training for anti-aircraft screws. Traditional target-drones have been generally manufactured from aluminum and/or wood. Recently, composite materials have been replacing them in virtue of their high strength-to-weight and stiffness-to-weight ratios. In particular, glass fiber-based composite materials are popular for the target-drone level vehicles because of the material cost and fabrication convenience.
    In this paper, as a part of the development activities for a complete target-drone vehicle, the stress analysis results are presented for a 685cc engine target-drone composite aerial vehicle wing. Composite materials used are H612 and… More >

  • Open Access

    ABSTRACT

    in silico Method for the Identification of Mycobacterial sp. Potential Drug Targets

    Ashutosh Singh1, Shruti Mishra2, Dhwani Raghav1, Asheesh shanker1, Vinay Sharma1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.6, No.2, pp. 119-124, 2008, DOI:10.3970/icces.2008.006.119

    Abstract Drug resistance has increased the pace of war against the ever-growing challenge of mycobacterial infections particularly with the growing menace of tuberculosis (TB).Previous studies reported several essential and virulent genes of mycobacterium like virS gene and mymA operon[1] through experimental approaches. However, Post genomic approach applied for the identification of targets for tuberculosis which includes the comparison of Mycobacterium tuberculosis CDC1551 proteome against database of essential genes and proteome of Homo sapiens. A total of approx 4000 proteins were studied and compared and 19 proteins were found to possess potentiality to call as Targets. More >

  • Open Access

    ABSTRACT

    A study of HID light reflector design of a streetlight

    Shy-Pin Cuo1, Dein Shaw2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 199-200, 2009, DOI:10.3970/icces.2009.009.199

    Abstract The purpose of this study is to present the process of development of HID (High Intensity Discharge) light reflector of a streetlight. The new application of HID light source for streetlight product is proposed in this study, the advantages of HID include low power consumption and single point light source emitting. The study includes the introduction of HID streetlight structure, the lighting efficiency comparison of various light sources (ex. High Pressure Sodium-lamp ``HPS'', High Bright LED ``HB LED'', etc\ldots ), and the design of streetlight reflector. The emphases of the experiment are focused at light reflector design; the streetlight module… More >

  • Open Access

    ARTICLE

    Pose Estimation of Space Targets Based on Model Matching for Large-Aperture Ground-Based Telescopes

    Zhengwei Li1,2, Jianli Wang1,*, Tao Chen1, Bin Wang1, Yuanhao Wu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.2, pp. 271-286, 2018, DOI:10.31614/cmc.2018.04005

    Abstract With the development of adaptive optics and post restore processing techniques, large aperture ground-based telescopes can obtain high-resolution images (HRIs) of targets. The pose of the space target can be estimated from HRIs by several methods. As the target features obtained from the image are unstable, it is difficult to use existing methods for pose estimation. In this paper a method based on real-time target model matching to estimate the pose of space targets is proposed. First, the physically-constrained iterative deconvolution algorithm is used to obtain HRIs of the space target. Second, according to the 3D model, the ephemeris data,… More >

  • Open Access

    ARTICLE

    Numerical investigation of penetration in Ceramic/Aluminum targets using Smoothed particle hydrodynamics method and presenting a modified analytical model

    Ehsan Hedayati1, Mohammad Vahedi2

    CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.3, pp. 295-323, 2017, DOI:10.3970/cmes.2017.113.307

    Abstract Radius of ceramic cone can largely contribute into final solution of analytic models of penetration into ceramic/metal targets. In the present research, a modified model based on radius of ceramic cone was presented for ceramic/aluminum targets. In order to investigate and evaluate accuracy of the presented analytic model, obtained results were compared against the results of the Florence’s analytic model and also against numerical modeling results. The phenomenon of impact onto ceramic/aluminum composites were modeled using smoothed particle hydrodynamics (SPH) implemented utilizing ABAQUS Software. Results indicated that, with increasing initial velocity and ceramic thickness and decreasing support layer thickness, the… More >

  • Open Access

    ARTICLE

    Real-Time Moving Targets Detection in Dynamic Scenes

    Fan Li1, Yang Yang

    CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.2, pp. 103-124, 2015, DOI:10.3970/cmes.2015.107.103

    Abstract The shift of the camera leads to unsteadiness of backgrounds in video sequences. The motion of camera will results in mixture of backgrounds and foregrounds motion. So it is a challenge for targets detection in dynamic scenes. A realtime moving target detection algorithm with low complexity in dynamic scenes is proposed in this paper. Sub-block based image registration is applied to remove the global motion of the video frame. Considering the blocks in one frame have different motion vectors, the global motion of each block is separately estimated. Then, a neighbor-based background modeling is applied to extract the moving objects.… More >

  • Open Access

    ARTICLE

    A Computational Study of High-Speed Droplet Impact

    T. Sanada1, K. Ando2, T. Colonius2

    FDMP-Fluid Dynamics & Materials Processing, Vol.7, No.4, pp. 329-340, 2011, DOI:10.3970/fdmp.2011.007.329

    Abstract When a droplet impacts a solid surface at high speed, the contact periphery expands very quickly and liquid compressibility plays an important role in the initial dynamics and the formation of lateral jets. The high speed impact results in high pressures that can account for the surface erosion. In this study, we numerically investigated a high speed droplet impacts on a solid wall. The multicomponent Euler equations with the stiffened equation of state are computed using a FV-WENO scheme with an HLLC Riemann solver that accurately captures shocks and interfaces. In order to compare the available theories and experiments, 1D,… More >

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