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  • Open Access

    ARTICLE

    The Regulatory Roles of microRNAs and Associated Target Genes during Early Somatic Embryogenesis in Liriodendron Sino-Americanum

    Dan Wang1, Fengjuan Lu1, Pengkai Wang1, Jiaji Zhang1, Lu Lu1, Yan Zhen1, Ye Lu1, Tielong Cheng2, Jisen Shi1,*, Jinhui Chen1,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.5, pp. 1445-1463, 2021, DOI:10.32604/phyton.2021.015499

    Abstract Somatic cells respond to considerable stress, and go through a series of phytohormone pathways, then forming an embryo. The developmental process is recorded as somatic embryogenesis (SE). One of the key components regulating SE are the microRNAs (miRNAs). Despite previous studies, it is still not clear exactly how miRNAs exert their function of regulating targets during conditionally activated early SE. Here, we use Liriodendron sino-americanum as a model system and perform a combined analysis of microfluidic chips and degradome sequencing to study this process. We identified a total of 386 conserved miRNAs and 153 novel miRNAs during early SE. According… More >

  • Open Access

    ARTICLE

    Dynamic Target Detection and Tracking Based on Quantum Illumination LIDAR

    Qinghai Li1, Ziyi Zhao2, Hao Wu1,*, Xiaoyu Li3,*, Qinsheng Zhu1, Shan Yang4

    Journal of Quantum Computing, Vol.3, No.1, pp. 35-43, 2021, DOI:10.32604/jqc.2021.016634

    Abstract In the detection process of classic radars such as radar/lidar, the detection performance will be weakened due to the presence of background noise and loss. The quantum illumination protocol can use the spatial correlation between photon pairs to improve image quality and enhance radar detection performance, even in the presence of loss and noise. Based on this quantum illumination LIDAR, a theoretic scheme is developed for the detection and tracking of moving targets, and the trajectory of the object is analyzed. Illuminated by the quantum light source as Spontaneous Parametric Down-Conversion (SPDC), an opaque target can be identified from the… More >

  • Open Access

    ARTICLE

    Upregulation of microRNA-451a improves endothelial cell function in atherosclerosis by direct targeting of macrophage migration inhibitory factor

    HONGXIA HU*, PING GUO, QIAN ZHAO, HAORAN LI, HUALEI LIU, CAIHONG MA

    BIOCELL, Vol.45, No.4, pp. 995-1004, 2021, DOI:10.32604/biocell.2021.012851

    Abstract This study aims to detect the expression of selected circulating microRNAs (miRNA), including miRNA-451a, miRNA-486-5p and miR-10b-5p, and their prospective roles as biomarkers in patients with atherosclerosis. For this purpose, levels of miRNAs were detected by real-time quantitative polymerase chain reaction (RT-qPCR) in case (N = 30) and healthy control (N = 30) groups. Receiver operating characteristic (ROC) curve analysis was carried out to evaluate the diagnostic ability of miRNAs. The correlations of miR-451a with lipid parameters were evaluated using Pearson’s correlation coefficients. HUVEC tested by ox-LDL was used as a cellular model of atherosclerosis. Cell viability and apoptosis were… More >

  • Open Access

    ARTICLE

    A Fog Covered Object Recognition Algorithm Based On Space And Frequency Network

    Ying Cui1, Shi Qiu2,*, Tong Li3

    Intelligent Automation & Soft Computing, Vol.28, No.2, pp. 417-428, 2021, DOI:10.32604/iasc.2021.016802

    Abstract It is difficult to recognize a target object from foggy images. Aiming at solving this problem, a new algorithm is thereby proposed. Fog concentration estimation is the prerequisite for image defogging. Due to the uncertainty of fog distribution, a fog concentration estimation model is accordingly proposed. Establish the brightness and gradient model in the spatial domain, and establish the FFT model in the frequency domain. Also, a multiple branch network framework is established to realize the qualitative estimation of the fog concentration in images based on comprehensive analysis from spatial and frequency domain levels. In the aspect of foggy image… More >

  • Open Access

    ARTICLE

    HPMC: A Multi-target Tracking Algorithm for the IoT

    Xinyue Lv1, Xiaofeng Lian2,*, Li Tan1, Yanyan Song1, Chenyu Wang3

    Intelligent Automation & Soft Computing, Vol.28, No.2, pp. 513-526, 2021, DOI:10.32604/iasc.2021.016450

    Abstract With the rapid development of the Internet of Things and advanced sensors, vision-based monitoring and forecasting applications have been widely used. In the context of the Internet of Things, visual devices can be regarded as network perception nodes that perform complex tasks, such as real-time monitoring of road traffic flow, target detection, and multi-target tracking. We propose the High-Performance detection and Multi-Correlation measurement algorithm (HPMC) to address the problem of target occlusion and perform trajectory correlation matching for multi-target tracking. The algorithm consists of three modules: 1) For the detection module, we proposed the You Only Look Once(YOLO)v3_plus model, which… More >

  • Open Access

    REVIEW

    Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic

    YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY*

    BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621

    Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will realistically aid large access to… More >

  • Open Access

    ARTICLE

    microR-1294-5p inhibits glycolytic metabolism of non-small cell lung cancer cells via targeting TMPRSS11B

    JI ZHU#, XIYING BO#, GENGXI JIANG, SHIHUA YAO, TIEJUN ZHAO*, LING CHEN*

    BIOCELL, Vol.45, No.3, pp. 639-647, 2021, DOI:10.32604/biocell.2021.012847

    Abstract Non-small cell lung cancer (NSCLC) cells intake and consume glucose at high efficiency by aerobic glycolysis to maintain robust cell growth and resist cell death. MicroRNAs (miRNAs) have been known to play pivotal roles in NSCLC development partly through mediating glycolysis. However, only a few miRNAs have been experimentally confirmed as critical regulators of glycolysis in NSCLC. TCGA datasets were analyzed to screen for differentially expressed miRNAs between NSCLC and normal tissues. The function of miR-1294-5p was determined in NSCLC cells by cell proliferation, glucose uptake, lactate release, and Extracellular Acidification Rate (ECAR) assays. The target of miR- 1294-5p was… More >

  • Open Access

    ARTICLE

    FBXW7 regulates epithelial barrier impairment in human bronchial epithelial cells in vitro by targeting apoptosis signal-regulating kinase1 via the p38 pathway

    JINGRONG SONG#, JUAN KANG#, WEI LV, YAN DONG, XIAOYING ZHANG*

    BIOCELL, Vol.45, No.3, pp. 723-731, 2021, DOI:10.32604/biocell.2021.014453

    Abstract Bronchial asthma is a common chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammatory cell infiltration, and airway remodeling. F-box/WD repeat-containing protein 7 (FBXW7), an E3 ubiquitin ligase, is required for various endothelial functions, such as cell migration, inflammation, and endothelial integrity. This study aimed to investigate the role of FBXW7 in lipopolysaccharide (LPS)-induced epithelial barrier impairment in bronchial epithelial cells in vitro. By using lentivirus-based technology, FBXW7 was overexpressed or silenced (24 h) in human bronchial epithelial (16HBE) cells, which were treated with LPS or not (24 h). Immunoprecipitation (IP) detection and Western blot analysis were used to evaluate… More >

  • Open Access

    ARTICLE

    miR-21-3p alleviates neuronal apoptosis during cerebral ischemiareperfusion injury by targeting SMAD2

    FEI TIAN*, GANG LIU, LINLIN FAN, ZHONGYUN CHEN, YAN LIANG,

    BIOCELL, Vol.45, No.1, pp. 49-56, 2021, DOI:10.32604/biocell.2021.013794

    Abstract Cerebral ischemia is due to the formation of blood clots or embolisms in the brain arteries, which leads to local brain tissue necrosis and neural cell apoptosis. Recent studies have shown that microRNA (miRNA) plays an important regulatory role in the pathological process of ischemic injury. The aim of this study is to investigate the role and the mechanism of miR-21-3p and drosophila mothers against decapentaplegic 2 (SMAD2) in cerebral ischemic reperfusion injured (CIRI) neural cells. The CIRI model was established by oxygen-glucose deprivation and recovery process for N2a cells. The cell viability and the apoptotic was evaluated by MTT… More >

  • Open Access

    ARTICLE

    PathVisio Analysis: An Application Targeting the miRNA Network Associated with the p53 Signaling Pathway in Osteosarcoma

    MERVIN BURNETT1, VITO RODOLICO2, FAN SHEN1, ROGER LENG1, MINGYONG ZHANG3, DAVID D. EISENSTAT4,5, CONSOLATO SERGI1,3,6,*

    BIOCELL, Vol.45, No.1, pp. 17-26, 2021, DOI:10.32604/biocell.2021.013973

    Abstract MicroRNAs (miRNAs) are small single-stranded, non-coding RNA molecules involved in the pathogenesis and progression of cancer, including osteosarcoma. We aimed to clarify the pathways involving miRNAs using new bioinformatics tools. We applied WikiPathways and PathVisio, two open-source platforms, to analyze miRNAs in osteosarcoma using miRTar and ONCO.IO as integration tools. We found 1298 records of osteosarcoma papers associated with the word “miRNA”. In osteosarcoma patients with good response to chemotherapy, miR-92a, miR- 99b, miR-193a-5p, and miR-422a expression is increased, while miR-132 is decreased. All identified miRNAs seem to be centered on the TP53 network. This is the first application of… More >

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