Open Access
ERRATUM
MicroRNA-200a Suppresses Cell Invasion and Migration by Directly Targeting GAB1 in Hepatocellular Carcinoma
Jianlin Wang*1,
Wenjie Song*1,
Weiwei Shen†1,
Xisheng Yang*, Wei Sun*, Sshibin Qu*, Runze Shang*,
Ben Ma*, Meng Pu*, Kaishan Tao*, Kefeng Dou*, Haimin Li*
* Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, P.R. China
† Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, P.R. China
Oncology Research 2019, 27(2), 281-282. https://doi.org/10.3727/096504019X15476499940873
Abstract
MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role
in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated
in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study.
Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we
aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Here we observed
that overexpression of miR-200a resulted in suppression of HCC metastatic ability, including HCC cell migration, invasion, and metastasis, in vitro and in vivo. Furthermore, bioinformatics and luciferase reporter assays
indicated that GAB1 is a direct target of miR-200a. Inhibition of GAB1 resulted in substantially decreased cell
invasion and migration similar to that observed with overexpression of miR-200a in HCC cell lines, whereas
restoration of GAB1 partially rescued the inhibitory effects of miR-200a. Taken together, these data provide
novel information for comprehending the tumor-suppressive role of miR-200a in HCC pathogenesis through
inhibition of GAB1 translation.
Keywords
Cite This Article
Wang, J., Song,
. W., Shen,
. W., Yang,
. X., Sun, W. et al. (2019). MicroRNA-200a Suppresses Cell Invasion and Migration by Directly Targeting GAB1 in Hepatocellular Carcinoma.
Oncology Research, 27(2), 281–282. https://doi.org/10.3727/096504019X15476499940873