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miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion via Targeting SOX4

Kejun Wang*1, Lin Yan*1, Fen Lu

* Department of Orthopedics, Jingzhou Central Hospital, Jingzhou, Hubei Province, P.R. China
† The First People’s Hospital of Jingzhou, Jingzhou, Hubei Province, P.R. China

Oncology Research 2019, 27(2), 157-163. https://doi.org/10.3727/096504018X15190861873459

Abstract

miR-363-3p has been shown to suppress tumor growth and metastasis in various human cancers. However, the function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found that overexpression of miR-363-3p markedly inhibited the proliferation, migration, and invasion of U2OS and MG63 cells. Moreover, we found that SOX4 was a direct target of miR-363-3p in OS cells. Overexpression of miR-363-3p significantly inhibited the expression of SOX4. Expression levels of miR-363-3p and SOX4 were negatively correlated in OS tissues. Finally, we found that restoration of SOX4 attenuated the suppressive effects of miR-363-3p on the proliferation, migration, and invasion of U2OS and MG63 cells. Therefore, our findings demonstrated that miR-363-3p served as a tumor suppressor in OS tissues by targeting SOX4.

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Cite This Article

APA Style
Wang, K., Yan, .L., Lu, F. (2019). Mir-363-3p inhibits osteosarcoma cell proliferation and invasion via targeting SOX4. Oncology Research, 27(2), 157-163. https://doi.org/10.3727/096504018X15190861873459
Vancouver Style
Wang K, Yan L, Lu F. Mir-363-3p inhibits osteosarcoma cell proliferation and invasion via targeting SOX4. Oncol Res. 2019;27(2):157-163 https://doi.org/10.3727/096504018X15190861873459
IEEE Style
K. Wang, .L. Yan, and F. Lu "miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion via Targeting SOX4," Oncol. Res., vol. 27, no. 2, pp. 157-163. 2019. https://doi.org/10.3727/096504018X15190861873459



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