Open Access

ARTICLE

miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion via Targeting SOX4

Kejun Wang^*1, Lin Yan^*1, Fen Lu^†

* Department of Orthopedics, Jingzhou Central Hospital, Jingzhou, Hubei Province, P.R. China
† The First People’s Hospital of Jingzhou, Jingzhou, Hubei Province, P.R. China

Oncology Research 2019, 27(2), 157-163. https://doi.org/10.3727/096504018X15190861873459

Abstract

miR-363-3p has been shown to suppress tumor growth and metastasis in various human cancers. However, the function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found that overexpression of miR-363-3p markedly inhibited the proliferation, migration, and invasion of U2OS and MG63 cells. Moreover, we found that SOX4 was a direct target of miR-363-3p in OS cells. Overexpression of miR-363-3p significantly inhibited the expression of SOX4. Expression levels of miR-363-3p and SOX4 were negatively correlated in OS tissues. Finally, we found that restoration of SOX4 attenuated the suppressive effects of miR-363-3p on the proliferation, migration, and invasion of U2OS and MG63 cells. Therefore, our findings demonstrated that miR-363-3p served as a tumor suppressor in OS tissues by targeting SOX4.

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