Se Ha Jang^1,2,#, Hyung Seok Kim^3,#, Jung Woo Eun^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Shujie Yin¹, Zong Li¹, Wen-Bin Ou^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069049 - 30 December 2025

Abstract Ferroptosis is an iron-dependent, excessive lipid peroxidation-driven form of regulated cell death. The core mechanisms of ferroptosis include lipid peroxidation cascade, System X_c⁻-glutathioneglutathione peroxidase 4 axis, iron and lipid metabolism chaos, the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis, and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis. Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins, differing fundamentally from ferroptosis. Both ferroptosis and cuproptosis exhibit dual roles (promote or inhibit) in cancers. And the sensitivity of different cancer types to ferroptosis varies, which may depend on special metabolic signatures (e.g., E-cadherin loss causes epithelial–mesenchymal More > Graphic Abstract

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

A. O. Onwudiwe, C. I. Onyemaechi^*, S. C. Achebe, P. O. Philip, O. A. Ugwu

Journal of Psychology in Africa, Vol.35, No.6, pp. 843-851, 2025, DOI:10.32604/jpa.2025.069734 - 30 December 2025

Abstract Despite high burden of mental disorders in Nigeria, access to care remains critically limited, with stigma, inadequate infrastructure, and economic constraints posing significant barriers. Integration of mental health and technology offers unprecedented opportunities to bridge this treatment gap. This paper explores the potential of digital mental health interventions like mobile applications and teletherapy, as viable solutions through which mental health services could be expanded. Leveraging Nigeria’s growing digital ecosystem and mobile phone penetration, these innovations can provide scalable, cost-effective, and culturally relevant interventions, particularly in underserved areas. However, challenges such as digital literacy gaps, socio-cultural More >

Sanggu Kim¹, Seongmo Yang¹, Soochong Kim^1,2,*

BIOCELL, Vol.49, No.12, pp. 2335-2364, 2025, DOI:10.32604/biocell.2025.072418 - 24 December 2025

Abstract Regenerative medicine has attracted increasing attention across diverse organs, including the skin, musculoskeletal tissues, eye, and nervous system, where structural repair is limited. Among these, skin wound care is particularly urgent and challenging because diabetic ulcers, pressure injuries, and severe burns often resist standard dressings, debridement, and revascularization, resulting in infection, amputation, and high costs. Platelet-rich plasma (PRP) has gained value because platelets release coordinated growth factors and cytokines (e.g., platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, and insulin-like growth factor-1) that modulate hemostasis, inflammation, angiogenesis,… More >

YANG-YANG SHUAI^1,2, PEI-PEI WANG¹, HAI-JUN ZHANG², HUI AO^1,*, WEI PENG¹, HONG ZHANG^1,2,*

BIOCELL, Vol.49, No.12, pp. 2299-2333, 2025, DOI:10.32604/biocell.2025.071569 - 24 December 2025

Abstract Breast cancer ranks first among cancer-related fatalities and is the most frequent cancer in women globally. ROS plays an important role in controlling the occurrence and progression of breast cancer. Increasing reports suggest that natural products and their derivatives are beneficial for the management of breast cancer via the regulation of reactive oxygen species (ROS). A summary of the known patterns of natural products that modulate ROS against breast cancer will contribute to the discovery of more natural medicines for clinical applications and the development of new drugs. In this review, the pharmacological effects of More >

Chenglu Lu^1,#, Huiting Zhang^2,#, Ujjal K. Bhawal^3,4, Lei Wang¹, Jingwu Li¹, Pangzhou Chen^5,*, Lewei Zhu^6,*

Oncology Research, Vol.33, No.12, pp. 3657-3678, 2025, DOI:10.32604/or.2025.069703 - 27 November 2025

Abstract The tumor microenvironment (TME) is a complex network composed of non-tumor cells, extracellular matrix, blood vessels, and various molecular signals that surround and profoundly influence tumor progression. As one of the key immune effector cells within the TME, mast cells (MCs) exhibit functional complexity, and their specific roles remain widely debated. Depending on the cancer type, spatial distribution, and interactions with other TME components, MCs can demonstrate dual regulatory capabilities—either promoting or inhibiting tumor growth. This characteristic has made them an important focus in current tumor immunology research. This review aims to systematically review the More >

Muhammad Noman Khan^1,2,3,*, Kang Tian², John R. Gordon⁴, Fang Li², Song-Ze Ding^1,*

Oncology Research, Vol.33, No.12, pp. 3837-3854, 2025, DOI:10.32604/or.2025.069408 - 27 November 2025

Abstract Objectives: Chemotherapy-induced lung inflammation limits the efficacy of anticancer therapies such as gefitinib in non-small cell lung cancer (NSCLC). Glutamic acid-leucine-arginine positive (ELR+) CXC chemokines and their receptors, CXC chemokine receptor 1 and 2 (CXCR1 and CXCR2), mediate both inflammatory responses and tumor progression. This study evaluated the effects of CXCR1/2 antagonism by G31P, a CXC motif chemokine ligand 8 (CXCL8)-mutated peptide, alone or in combination with gefitinib, on lung cancer growth and chemotherapy-induced pulmonary inflammation. Methods: Human NSCLC cell lines (A549 and H460) were treated with gefitinib and/or G31P. Cell proliferation, apoptosis, and signaling… More > Graphic Abstract

Huan Wang^1,#, Jindong Xie^1,#, Na Li¹, Qianwen Liu¹, Wenqi Song¹, Wenkuan Chen¹, Cheng Peng^2,*, Hailin Tang^1,*

Oncology Research, Vol.33, No.12, pp. 3789-3800, 2025, DOI:10.32604/or.2025.067592 - 27 November 2025

Abstract Solid tumors comprise the majority of the global cancer burden, with their incidence and associated mortality posing considerable challenges to public health systems. With population growth and aging, the burden of these tumors is anticipated to increase further in the coming decades. The progression of solid tumors depends on dynamic interactions between malignantly transformed cells and the tumor microenvironment (TME). Immune checkpoint inhibitor therapy improves T cell-mediated antitumor activity by suppressing regulatory pathways, such as programmed cell death protein 1/programmed death-ligand 1. Nonetheless, its widespread application is constrained by drug resistance. In this comprehensive review, More >