Wei Ni^*†‡, Lin Luo^*†‡, Ping Zuo^*†‡, Renping Li^*†‡, Xiaobing Xu^*†‡, Fan Wen^*†‡, Dong Hu^*†‡

Oncology Research, Vol.27, No.6, pp. 703-712, 2019, DOI:10.3727/096504018X15426775024905

Abstract Glioma is a commonly diagnosed brain tumor that shows high mortality rate. Despite the great advancement of cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However, long-term chemotherapy usually causes serious side effects or complications. It is desirable to take strategies to enhance the efficacy of current chemotherapy. In the present study, we observed obvious upregulation of miR-374a in glioma cells. More importantly, we found that knockdown of miR-374a was able to enhance the etoposide-induced cytotoxicity against glioma cells. Mechanically, we demonstrated that FOXO1 was the target of miR-374a in glioma. Treatment with… More >

Leonard Lothstein^*, Judith Soberman^†, Deanna Parke^*, Jatin Gandhi^*, Trevor Sweatman^‡, Tiffany Seagroves^*

Oncology Research, Vol.28, No.5, pp. 451-465, 2020, DOI:10.3727/096504020X15898794315356

Abstract Triple-negative breast cancer (TNBC) is unresponsive to antiestrogen and anti-HER2 therapies, requiring the use of cytotoxic drug combinations of anthracyclines, taxanes, cyclophosphamide, and platinum compounds. Multidrug therapies achieve pathological cure rates of only 20–40%, a consequence of drug resistance and cumulative dose limitations necessitated by the reversible cardiotoxic effects of drug therapy. Safer and more effective treatments for TNBC are required to achieve durable therapeutic responses. This study describes the mechanistic analyses of the novel anthracycline, pivarubicin, and its in vivo efficacy against human primary TNBC. Pivarubicin directly activates PKCd, triggers rapid mitochondrial-dependent apoptosis, and circumvents resistance conferred by overexpression… More >

Tsung-Kun Chang^*†, Tzu-Chieh Yin^‡§, Wei-Chih Su^*†, Hsiang-Lin Tsai^*¶, Ching-Wen Huang^*¶, Yen-Cheng Chen^*, Ching-Chun Li^*, Po-Jung Chen^*, Cheng-Jen Ma^*§, Kuo-Hsiang Chuang^#, Tian-Lu Cheng^**, Jaw-Yuan Wang^{*†¶††‡‡§§}

Oncology Research, Vol.28, No.7-8, pp. 801-809, 2020, DOI:10.3727/096504021X16218531628569

Abstract Irinotecan, a topoisomerase inhibitor, is a common cytotoxic agent prescribed for metastatic colorectal cancer (mCRC) patients. Diarrhea is the most common adverse event (AE). The underlying mechanism of irinotecaninduced diarrhea is intestinal mucosal damage caused by SN-38 (active metabolite of irinotecan) hydrolyzed from SN-38G (inactive metabolite) by bacterial -glucuronidase ( G). According to an animal study, silymarin reduces the activity of bacterial G without impairing antitumor efficacy. We conducted a prospective openlabel pilot study to evaluate the effect of silymarin as supplementation in reducing toxicities of mCRC patients undergoing irinotecan-based chemotherapy. We enrolled and randomized 70 mCRC patients receiving first-line… More >

NERGIZ HACER TURGUT^1,*, HUSEYIN GUNGOR², MEHMET EKICI³, MUMIN ALPER ERDOGAN⁴, MEHMET ONDER KARAYIGIT⁵, HAKI KARA²

BIOCELL, Vol.46, No.9, pp. 2111-2122, 2022, DOI:10.32604/biocell.2022.020383

Abstract Side effects of cisplatin, especially dose-dependent nephrotoxicity, are major factors limiting its use in cancer. Boldine ((S)-2, 9-dihydroxy-1, 10-dimethoxy-aporphine) is a natural alkaloid known for its strong antioxidant activity present in leaves/bark of boldo tree (Peumus boldus Molina), a native tree in Chile. Here, we aimed to investigate the nephroprotective effect of boldine and its underlying mechanisms on cisplatin-induced rat renal injury. Thirty Wistar albino rats divided into 5 groups (Control, Cis, Bold.40, Cis + Bold.20, Cis + Bold.40 groups) were used. Rats received boldine (20 or 40 mg/kg/day), or vehicle (saline) intraperitoneal for 14 days and a single dose… More >

SANTOSH KUMAR KARN¹, ADITYA UPADHYAY², AWANISH KUMAR^2,*

BIOCELL, Vol.46, No.7, pp. 1771-1777, 2022, DOI:10.32604/biocell.2022.018845

Abstract Chemicals are comprehensively used worldwide to control herbs, weeds, pests, and other competing agents with various growing crops. The consumption of crops grown with these chemicals (even in small quantities) can upshot into accumulation in the human body. People can accidentally inhale these hazardous chemicals if they are in an area where they were applied. These chemicals can be ingested in a human with contaminated food and drinks. Ultimately it causes various adverse effects (chronic toxicity, teratogenic, mutagenic, carcinogenic effect, reproductive, and organ toxicity) on human health. Among the pool of these chemicals used as pesticides in the environment, exposure… More >

Ying Liu^1,3,*, Jingye Chen^1,3, Xiaohao Li^1,3, Shaoxia Yang¹, Hanqiao Hu^1,3, Yingbin Xue^2,3,*

Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 975-987, 2022, DOI:10.32604/phyton.2022.019057

Abstract In order to investigate the effects of Manganese (Mn) toxicity stress on the growth and gene expression at the seedling stage of soybean, soybean seedlings were treated with normal Mn concentration (5 μmol/L MnSO₄) and excess Mn concentration (100 μmol/L MnSO₄) by the method of hydroponic culture in this study. When soybean was subjected to Mn toxicity stress, excessive Mn could affect seedling growth, root development, the number of Mn oxide spots in leaves, and the Mn accumulation content in different parts of soybean. With the increase of exogenous Mn concentration and the prolongation of culture time, the shoot and… More >

Bing Zhang¹, Sujie Yang¹, Mengru Liu¹, Panyue Wen², Xiuyu Liu¹, Gang Tang^1,*, Xiangrong Xu^3,4,*

Journal of Renewable Materials, Vol.10, No.5, pp. 1201-1220, 2022, DOI:10.32604/jrm.2022.018047

Abstract Biomass phytic acid has potential flame retardant value as the main form of phosphorus in plant seeds. In this study, phytate-based flame retardants aluminum phytate (PA-Al) and iron phytate (PA-Fe) were synthesized and characterized. Subsequently, they were introduced into rigid polyurethane foam (RPUF) as flame retardants by one-step water-blown method. The results indicated that RPUF/PA-Fe30 exhibited the highest char residue of 22.1 wt%, significantly higher than 12.4 wt% of RPUF. Cone calorimetry analysis showed that the total heat release (THR) of RPUF/PA-Al30 decreased by 17.0% and total smoke release (TSR) decreased by 22.0% compared with pure RPUF, which were the lowest, demonstrating… More > Graphic Abstract

ZHIMEI TANG, QIANG ZHANG^*

BIOCELL, Vol.46, No.2, pp. 357-366, 2022, DOI:10.32604/biocell.2022.015958

Abstract Flavonoids are a class of phytochemical molecules abundant in many plants, fruits, vegetables, and leaves. Flavonoids possess a series of significant biological activities, including anticancer, antioxidant, antiviral, and antiinflammatory properties. They become an important source of dietary supplements and natural health products. Though many studies confirmed the safety of flavonoids, the potential toxicity of flavonoids is still a remarkable field of research to be explored. The enthusiasm for flavonoids expressed by the public has sometimes overlooked their toxicity and also consumed the flavonoids exceeding the body requirements. The current review focused on the potential toxicity of flavonoids to make the… More >

ALI H. ABU ALMAATY¹, BASMA M. HENDAM², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, YASMIN M. ABD EL-AZIZ¹

BIOCELL, Vol.46, No.1, pp. 219-234, 2022, DOI:10.32604/biocell.2022.017623

Abstract The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract. Twenty adult male albino rats were equally distributed into four groups; Group (I) treated with physiological saline (control group), Group (II) was orally gavaged by 200 mg/kg of T. granosa body extract day after day, Group (III) was intoxicated by KBr (150 mg/kg bwt day after day orally) and finally, Group (IV) was given a combination of T. granosa flesh body extract plus KBr with similar doses in the second and third… More >

JELAN MOFEED^1,2, MOHAMED DEYAB³, ABDELNASER MOHAMED³, MAHMOUD MOUSTAFA^4,5, SALLY NEGM^6,7, EMAD EL-BILAWY¹

BIOCELL, Vol.46, No.1, pp. 247-261, 2022, DOI:10.32604/biocell.2022.015966

Abstract

Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells… More >