Xiuqing Qian^1,2, Fan yuan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 89-89, 2019, DOI:10.32604/mcb.2019.07041

Abstract Elevated intraocular pressure (IOP) is the most important risk factor for disease progression in glaucoma patients. The elevation is predominantly due to the increase in the aqueous outflow resistance in the trabecular outflow pathway. Recent data have shown that the resistance increase is correlated with changes in the tissue stiffness. To this end, we developed a mathematical model to simulate how the tissue stiffness can affect the deformation of the trabecular meshwork (TM) that can be determined experimentally. The goal of the study is to develop a method to non-invasively determine the TM stiffness in patients through measurement of the… More >

Jing Zhang^1,2,3, Xiuqing Qian^1,2, Haixia Zhang^1,2, Zhicheng Liu^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 301-314, 2018, DOI: 10.31614/cmes.2018.04239

Abstract Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system (AOS). However, there is still no consensus about exact location of the increased outflow resistance of aqueous humor, and the mechanism is not perfect. In addition, it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology. In this paper, a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork, juxtacanalicular meshwork (JCM) and Schlemm’s canal in response… More >