Zhong Ren^1,2,3,#, Shuiming Zhang^1,#, Yuzhi Fei¹, Zhu Chen³, Yue Zhao³, Xin Meng³, Hongfei Zhao^2,*, Jie Ren^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2927-2947, 2025, DOI:10.32604/phyton.2025.067310 - 30 September 2025

Abstract Acer paxii belongs to the evergreen species of Acer, but it exhibits a unique feature of reddish leaves in fall in subtropical regions. Although the association of AP2/ERF transcription factors with color change has been well-documented in prior research, molecular investigations focusing on AP2/ERF remain notably lacking in Acer paxii. This research focuses on performing an extensive genome-wide investigation to identify and characterize the AP2/ERF gene family in Acer paxii. As a result, 123 ApAP2/ERFs were obtained. Phylogenetic analyses categorized the ApAP2/ERF family members into 15 subfamilies. The evolutionary traits of the ApAP2/ERFs were investigated by analyzing their… More >

Jianwei Wang^1,2, Xinzhi Yang³, Lvbiao Lin⁴, Jianbo Yu^5,*, Jie Mao^4,*

Oncology Research, Vol.33, No.10, pp. 3023-3040, 2025, DOI:10.32604/or.2025.065380 - 26 September 2025

Abstract Objectives: Glioma, as the most lethal primary brain malignancy with poor prognosis, requires further elucidation on the functional role of long noncoding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1) in its pathogenesis, despite its established oncogenic functions in other cancers. Therefore, this study sought to characterize the oncogenic role and molecular mechanism of DDX11-AS1 in glioma. Methods: DDX11-AS1 expression levels were analyzed in clinical surgical glioma specimens and publicly available datasets. The functional roles of DDX11-AS1 on glioma cell proliferation and migration were investigated using in vitro knockdown and overexpression assays. In vivo tumor growth was assessed… More > Graphic Abstract

Imene Tatar Caliskan^1,2, George Dzorgbenya Ametefe³, Aziz Caliskan⁴, Su-Ee Lau^1,5, Yvonne Jing Mei Liew⁶, Nur Kusaira Khairul Ikram⁵, Boon Chin Tan^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2229-2254, 2025, DOI:10.32604/phyton.2025.067225 - 29 August 2025

Abstract Myeloblastosis (MYB) transcription factors (TFs) are evolutionarily conserved regulatory proteins that are crucial for plant growth, development, secondary metabolism, and stress adaptation. Recent studies have highlighted their crucial role in coordinating growth–defense trade-offs through transcriptional regulation of key biosynthetic and stress-response genes. Despite extensive functional characterization in model plants such as Arabidopsis thaliana, systematically evaluating the broader functional landscape of MYB TFs across diverse species and contexts remains necessary. This systematic review integrates results from 24 peer-reviewed studies sourced from Scopus and Web of Science, focusing on the functional diversity of MYB TFs, particularly in relation… More >

Yiqin He^1,2, Chenhan Hu^1,2, Xiangshu Meng^1,2, Rundong Ma^1,2, Kexin Duan^1,2, Yu Guo^2,3, Changqing Liu^1,2, Caiyun Ma^1,2, Gaofeng Liu^1,2,*, Chunjing Wang^1,2,*

BIOCELL, Vol.49, No.6, pp. 1037-1055, 2025, DOI:10.32604/biocell.2025.064633 - 24 June 2025

Abstract Background: Mesenchymal stem cells (MSCs) have shown great potential in treating neurodegenerative diseases, including Parkinson’s disease (PD), due to their ability to differentiate into neurons and secrete neurotrophic factors. Genetic modification of MSCs for PD treatment has become a research focus. Methods: In this study, rat pulmonary mesenchymal stem cells (PMSCs) were transduced with lentiviral vectors carrying Lmx1a/NeuroD1 to establish genetically engineered PMSCs (LN-PMSCs) and induce their differentiation into dopaminergic neurons. The LN-PMSCs were then transplanted into the right medial forebrain bundle region of PD model rats prepared using the 6-Hydroxydopamine (6-OHDA) method. Four weeks… More >

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

Saif Ullah^1,2, Izhar Ali^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1029-1045, 2025, DOI:10.32604/phyton.2025.064608 - 30 April 2025

Abstract Nitrogen (N) assimilation is crucial for the growth and development of C₃ plants, as it converts inorganic N into organic forms, important for protein synthesis, nucleic acids and other vital biomolecules. However, abiotic stressors such as drought, salinity, extreme temperatures and others significantly impact N uptake and utilization, thereby hindering plant growth and development. Recent advances in molecular biology have illuminated the complex networks that govern N assimilation under these stressful conditions, emphasizing the role of transcription factors, regulatory genes, and stress-responsive pathways. This review provides an integrated perspective on the latest research in nitrogen metabolism… More >

Yuhang Li¹, Li Sun¹, Tao Wang¹, Bingjun Yu², Zhihong Gao³, Xiaochun Shu¹, Tengyue Yan¹, Weibing Zhuang^1,2,*, Zhong Wang^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1211-1223, 2025, DOI:10.32604/phyton.2025.063647 - 30 April 2025

Abstract bHLH transcription factors, widely exist in various plants, and are vital for the growth and development of these plants. Among them, many have been implicated in anthocyanin biosynthesis across various plants. In the present study, a PdbHLH57 gene, belonging to the bHLH IIIf group, was characterized, which was isolated and cloned from the colored-leaf poplar ‘Zhongshancaiyun’ (ZSCY). The cDNA sequence of PdbHLH57 was 1887 base pairs, and the protein encoded by PdbHLH57 had 628 amino acids, the isoelectric point and molecular weight of which were 6.26 and 69.75 kDa, respectively. Through bioinformatics analysis, PdbHLH57 has been classified… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

Abstract This article has no abstract. More >

XIUWANG WEI¹, JIANBO LIANG¹, HUANWEN HUANG¹, DAMING YANG¹, XINXIN WANG¹, XIUJIA WANG¹, CHANGSHENG CHEN¹, KAIQIANG LI¹, TAISEN PANG¹, BIN HU¹, FENGNING WU^2,*

Oncology Research, Vol.33, No.1, pp. 161-169, 2025, DOI:10.32604/or.2024.048054 - 20 December 2024

Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >

Jianbo Fei^1,2,4, Zhibo Liu¹, Piwu Wang^1,3, Jing Qu², Siyan Liu¹, Shuyan Guan^1,3,*, Yiyong Ma^1,3

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3617-3635, 2024, DOI:10.32604/phyton.2024.052704 - 31 December 2024

Abstract The WRKY transcription factors play important roles in various biological processes such as plant development, defense regulation, and stress response. Despite this, there is limited information available on drought-related WRKY genes in maize. Through RNA sequencing (RNA-seq) analysis, a WRKY transcription factor called ZmWRKY25 was identified in this study. ZmWRKY25 belongs to Group II and is localized in the nucleus. Protein interaction analysis revealed that ZmWRKY25 interacts with several proteins involved in the abscisic acid (ABA) signal pathway. Expression of ZmWRKY25 was found to be up-regulated in response to drought, salt, and ABA treatments in tobacco plants. More >