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  • Open Access

    ARTICLE

    Placenta-derived mesenchymal stem cells attenuate secondary brain injury after controlled cortical impact in rats by inhibiting matrix metalloproteinases

    PING YANG1,2,3, YUANXIANG LAN1,2, ZHONG ZENG1,2, YAN WANG1,2, HECHUN XIA1,2,*

    BIOCELL, Vol.48, No.1, pp. 149-162, 2024, DOI:10.32604/biocell.2023.042367

    Abstract Background: As a form of biological therapy, placenta-derived mesenchymal stem cells (PDMSCs) exhibit considerable promise in addressing the complex pathological processes of traumaticbrain injury (TBI) due to their multi-target and multi-pathway mode of action. Material & Methods: This study investigates the protective mechanisms and benefits of PDMSCs in mitigating the effects of controlled cortical impact (CCI) in rats and glutamate-induced oxidative stress injury in HT22 cells in vitro. Our primary objective is to provide evidence supporting the clinical application of PDMSCs. Results: In the in vivo arm of our investigation, we observed a swift elevation of matrix metalloproteinase-9 (MMP-9) in… More > Graphic Abstract

    Placenta-derived mesenchymal stem cells attenuate secondary brain injury after controlled cortical impact in rats by inhibiting matrix metalloproteinases

  • Open Access

    ARTICLE

    Serial Multiple Mediation of the Relationship between Positive Coping Style and Post-Traumatic Growth among Chinese College Students in the Aftermath of COVID-19

    Qi Li, Jinsheng Hu*, Peng Wan

    International Journal of Mental Health Promotion, Vol.25, No.11, pp. 1173-1186, 2023, DOI:10.32604/ijmhp.2023.030343

    Abstract

    Given the ongoing character of COVID-19, higher-education students encountered multifaceted pressures brought about by the pandemic and had to overcome many difficulties during this period. Accordingly, it is imperative to identify the factors that may have protective effects on the social functioning and mental status of college students in the aftermath of COVID-19. This cross-sectional study sought to ascertain the internal mechanism of positive coping (PC) styles affecting post-traumatic growth (PTG) and considered the mediating roles of cognitive reappraisal (CR), psychological resilience (PR), and deliberate rumination (DR), which are essential for understanding how and to what extent these factors shaped… More >

  • Open Access

    ARTICLE

    Effectiveness of Post-Traumatic Growth Intervention to Promote Positive PostTraumatic Traits in Chinese Breast Cancer Patients: A Randomized Controlled Trial

    Cuirong Xu1,*, Han Yan2, Dawei Xu3, Guanjie Chen5, Qian Xu2, Kunpeng Li6, Yehao Rui7, Zanmin Song3, Neeraj Gill3, Jing Sun3,4,*

    International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1089-1102, 2023, DOI:10.32604/ijmhp.2023.030526

    Abstract Objective: The purpose of this study was to evaluate the effectiveness of post-traumatic growth (PTG) model-based intervention to improve positive psychological traits in Chinese breast cancer patients. Design: A randomized control trial of a psychological group intervention based on PTG model. Methods: The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264. A total of 92 patients with breast cancer were recruited. The participants were randomly assigned to the experimental group (n = 46) and the control group (n = 46). A six-session psychological group intervention based on PTG model was implemented in… More >

  • Open Access

    ARTICLE

    Coping with Trauma: The Relationship between Religiosity, Spirituality, and Post-Traumatic Symptoms among Civilians Exposed to Ongoing Rocket-Fire

    Jonathan T. Wolkinson, Michael Weinberg*

    International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1137-1145, 2023, DOI:10.32604/ijmhp.2023.029641

    Abstract Living under ongoing shelling and missile attacks could cause a widespread of disruption of everyday life and emotional distress. Coping with such distress could be associated with the personal resources of religion and spirituality. The present study aimed to examine the relationships between religiosity and spirituality with Post Traumatic stress Disorder (PTSD) symptoms among a civilian population frequently exposed to missile and rocket threats. One hundred and twenty-four (N = 124) civilian participants living within 10 km from shelling and missile attacks fired towards them, completed demographic, religiosity, spirituality, and PTSD questionnaires. The study findings demonstrate that religiosity is associated… More >

  • Open Access

    ARTICLE

    Consultations de suivi à long terme d’adultes guéris d’un cancer survenu dans l’enfance : vécus traumatiques et travail de narration. Récits dans l’après-coup de la maladie

    M. Laget, L. Fasse, B. Fresneau, E. Ricadat, S. Rivollet

    Psycho-Oncologie, Vol.16, No.2, pp. 267-272, 2022, DOI:10.3166/pson-2022-0190

    Abstract Dans le cadre du dispositif de suivi médical destiné aux adultes guéris d’un cancer pédiatrique à l’Institut Gustave-Roussy (Villejuif, France), un entretien psychologique est proposé. Cet article s’appuie sur 198 entretiens auprès de patients ayant entre 18 et 67 ans, diagnostiqués entre 0 et 24 ans. Ces rencontres donnent à entendre la subjectivité du vécu du cancer et de la guérison, révélant les traces de cette expérience dans l’après-coup. Les enjeux de l’activité narrative amorcée dans le cadre de cette consultation, et pouvant se poursuivre au-delà, sont abordés dans une perspective métapsychologique. More >

  • Open Access

    ARTICLE

    Reciprocal Association between Psychological Distress and PTSD and Their Relationship with Pre-Displacement Stressors among Displaced Women

    Erhabor S. Idemudia1, Babatola D. Olawa1,*, Gail E. Wyatt2, Norweeta G. Milburn2

    International Journal of Mental Health Promotion, Vol.25, No.5, pp. 699-710, 2023, DOI:10.32604/ijmhp.2023.026852

    Abstract It is established in the psychological literature that pre-displacement stressors, PTSD symptoms, and psychological distress are associated among internally displaced persons. However, existing studies have not demonstrated the mechanism underlying these associations. This study compared two explanatory models; one with PTSD symptoms severity explaining the indirect association between pre-displacement stressors and psychological distress, and the other with psychological distress explaining the indirect relationship between pre-displacement stressors and PTSD symptoms severity. In a cross-sectional design, 631 women (Mean age = 31.18 ± 8.59) were conveniently and purposely selected from the displaced women harboured in two camps in Borno State, Nigeria, due… More >

  • Open Access

    ARTICLE

    Diagnosis of Middle Ear Diseases Based on Convolutional Neural Network

    Yunyoung Nam1, Seong Jun Choi2, Jihwan Shin1, Jinseok Lee3,*

    Computer Systems Science and Engineering, Vol.46, No.2, pp. 1521-1532, 2023, DOI:10.32604/csse.2023.034192

    Abstract An otoscope is traditionally used to examine the eardrum and ear canal. A diagnosis of otitis media (OM) relies on the experience of clinicians. If an examiner lacks experience, the examination may be difficult and time-consuming. This paper presents an ear disease classification method using middle ear images based on a convolutional neural network (CNN). Especially the segmentation and classification networks are used to classify an otoscopic image into six classes: normal, acute otitis media (AOM), otitis media with effusion (OME), chronic otitis media (COM), congenital cholesteatoma (CC) and traumatic perforations (TMPs). The Mask R-CNN is utilized for the segmentation… More >

  • Open Access

    ARTICLE

    Exploring the Impact of Crisis and Trauma on the Mental Health and Psychological Well-Being of University Students in Northern Haiti

    Michael Galvin1,2,3,*, Guesly Michel3, Henri-Claude Saintelmond4, Carolyn Lesorogol5, Jean-François Trani5, Lora Iannotti5

    International Journal of Mental Health Promotion, Vol.25, No.2, pp. 173-191, 2023, DOI:10.32604/ijmhp.2023.018800

    Abstract In recent decades, Haiti has been subject to man-made and natural disasters that have left its citizens vulnerable to a range of shocks. With a weak state unable to protect its populace, Haitians are exposed to some of the highest levels of poverty and violence in the Western Hemisphere. In recent years, Haitians have experienced two crises that this study analyzes: the instability and political violence of “peyi lòk” as well as the global pandemic of COVID-19. This community-based assessment explores the impact of these two crises on the mental health and psychological well-being of 38 Haitian university students in… More >

  • Open Access

    CASE REPORT

    Delayed Bilateral, Post-Traumatic Extra-Subdural Hematomas in a Patient with Meningioma

    Giuseppe Emmanuele Umana1,*, Gianluca Ferini2, Antonio Crea1, Bipin Chaurasia3, Vishal Chavda4, Leonardo Corbino1, Daniele Franceschini1, Maria Grazia Tranchina5, Marco Fricia1, Francesca Graziano6, Giovanni Federico Nicoletti6, Salvatore Cicero1, Gianluca Scalia6

    Oncologie, Vol.24, No.2, pp. 341-348, 2022, DOI:10.32604/oncologie.2022.021347

    Abstract Concomitant acute epidural hematoma (EDH) and subdural hematoma (SDH) is a rare finding, and its bilateral onset has not yet been reported in literature. We present the first report of a patient affected by post-traumatic concomitant EDH and SDH, with the contralateral, delayed onset of another, associated with meningioma previously treated with gamma knife. A 60-year-old female patient with a history of simple focal seizures with motor symptoms and well-controlled by drugs since childhood, arterial hypertension, and incidental diagnosis of multiple meningiomas was referred to our department after falling down the stairs. Initially, the patient was prescribed gamma knife treatment… More >

  • Open Access

    ARTICLE

    Salubrinal alleviates traumatic spinal cord injury through suppression of the eIF2α/ATF4 pathway in mouse model

    XINFU FAN1,2,#, JIE CHEN3,#, ZONGMENG ZHANG4,#, FANGHUI CHEN5, HAOSEN WANG6, YAFEI CAI6, JUN LI7,*

    BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269

    Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in mice after SCI. Administration of… More >

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