KSENIA S. STAFEEVA1, NATALIA A. SAMOYLOVA1, OLGA A. KARANDEEVA1, VERONIKA V. NESTEROVA1, KIRILL A. STARODUBTSEV1, EVGENY V. MIKHAILOV2, ILYA O. KRUTOV2, EVGENY S. POPOV3, NATALIA S. RODIONOVA4, ANASTASIA V. KOKINA1,5, ARTEM P. GUREEV1,5,*
BIOCELL, Vol.49, No.1, pp. 7-20, 2025, DOI:10.32604/biocell.2024.058339
- 24 January 2025
Abstract Objective: The objective of this study was to determine the level of methotrexate (MTX) toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus, Bifidobacterium, and Lactobacillus species on intestinal cells during MTX treatment. Methods: Mice were divided into three groups: control, MTX group (received MTX injections), and MTX + probiotics group (received MTX injections along with a diet containing probiotics). Morphological and histological changes, the level of mitochondrial DNA (mtDNA) damage, the level of lipid peroxidation products, and gene expression in the mice’s small intestine were assessed. Results: We… More >
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