HUAQING MO^#, JINGYI SHEN^#, YUXIAO ZHONG, ZENAN CHEN, TONG WU, YANYU LV^*, YANYAN XIE, YANRONG HAO^*

Oncology Research, Vol.30, No.4, pp. 187-199, 2022, DOI:10.32604/or.2022.027534

Abstract Nasopharyngeal carcinoma (NPC) is the most prevalent human primary malignancy of the head and neck, and the presence of vasculogenic mimicry (VM) renders anti-angiogenic therapy ineffective and poorly prognostic. However, the underlying mechanisms are unclear. In the present study, we used miR-940 silencing and overexpression for in vitro NPC cell EdU staining, wound healing assay and 3D cell culture assay, and in vivo xenograft mouse model and VM formation to assess miR-940 function. We found that ectopic miR-940 expression reduced NPC cell proliferation, migration and VM, as well as tumorigenesis in vivo. By bioinformatic analysis, circMAN1A2 was identified as a… More >

Elena Andreucci^*1, Anna Laurenzana^*, Silvia Peppicelli^*, Alessio Biagioni^*, Francesca Margheri^*, Jessica Ruzzolini^*, Francesca Bianchini^*, Gabriella Fibbi^*, Mario Del Rosso^*†, Chiara Nediani^*, Simona Serratì^‡, Livia Fucci^§, Michele Guida^¶, Lido Calorini^*†1

Oncology Research, Vol.28, No.9, pp. 873-884, 2020, DOI:10.3727/096504021X16273798026651

Abstract Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows adaptation of melanoma cells to different hostile conditions and guarantees tumor survival and disease progression, including aggressive features such as drug resistance. Indeed, almost 50% of melanoma rapidly develop resistance to the BRAFV600E inhibitor vemurafenib, with fast tumor dissemination, a devastating consequence for patients’ outcomes. Vasculogenic mimicry (VM), the ability of cancer cells to organize themselves in perfused vascular-like channels, might sustain tumor spread by providing vemurafenibresistant cancer cells with supplementary ways to enter into circulation and disseminate. Thus, this… More >

HASSAN BAYDOUN¹, YUJI KATO¹, HIROKI KAMO¹, ANNA HÜSCH^1,2, HAYATO MIZUTA¹, RYOTA KAWAHARA¹, SIRO SIMIZU^1,*

Oncology Research, Vol.32, No.4, pp. 607-614, 2024, DOI:10.32604/or.2023.030304

Abstract

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic reticulum. In humans, biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family; nonetheless, biological functions of protein C-mannosylation are not yet fully understood, especially in tumor progression. Vasculogenic mimicry (VM) is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells, enabling the tumors to form matrix-embedded vasculogenic structures, containing plasma and blood cells to meet the metabolic demands of rapidly growing tumors. In this study, we focused on DPY19L3, a C-mannosyltransferase, and aimed to unravel its role in… More >